Seminoma of the testis: Results of treatment and patterns of failure after radiation therapy

Prognostic Factors in Testicular Germ Cell Tumours Experiences from 1058 Consecutive Cases

“…Similar results were reported by PECKHAM (9) and THOMAS et coll. (21). In the analysis of time to relapse, the size of the retroperitoneal metastases was not related to the prognosis; this could be a consequence of the rather crude classification of this parameter adopted in the present analysis.…”

Chemotherapy of metastatic seminoma

“…Since 80-90% of all relapses have been shown to occur within 2-3 years after remission induction, most of our complete responders probably might attain continuous CR (Calman et al, 1979;Thomas et al, 1982). However, with respect to the limited number of patients and the retrospective design of this analysis, no definite conclusions can yet be made on the therapeutic superiority of any one of the different chemotherapeutic regimens used.…”

“…Seminomas, which account for -40% (27-71%) of testicular cancers, generally tend to present as local (Stage I) or locoregional (Stage II) disease in 70-90% of the patients (Calman et al, 1979;Dixon & Moore, 1952;Maier et al, 1968;Mostofi, 1973;Thomas et al, 1982). Orchiectomy and retroperitoneal radiotherapy in Stage I and minimal Stage II disease usually result in an excellent overall prognosis, with 5-year survival rates approaching 90%.…”

“…Orchiectomy and retroperitoneal radiotherapy in Stage I and minimal Stage II disease usually result in an excellent overall prognosis, with 5-year survival rates approaching 90%. However, long-term results have remained rather poor with up to 40-50% relapses when radiotherapy served as the sole treatment of bulky Stage II disease (Ball et al, 1982;Smith et al, 1979;Thomas et al, 1982).…”

The treatment of advanced seminoma with chemotherapy and radiotherapy

“…Conventional treatment with orchidectomy and abdominal irradiation in this group has resulted in excellent results approximately 95% of patients being alive and disease free five years after completion of treatment (Read et al, 1983;Peckham, 1981). For patients with more advanced abdominal disease the results of radiotherapy alone are less encouraging; a five year survival rate of 40% being a common finding (Ball et al, 1982;Thomas et al, 1982).…”