PLoS ONE volume 9, issue 6, Pe98330 2014 DOI: 10.1371/journal.pone.0098330 View full text
Yvonne G. van der Zwan, Martin A. Rijlaarsdam, Fernando J. Rossello, Amanda J. Notini, Suzan de Boer, D. Neil Watkins, Ad J. M. Gillis, Lambert C. J. Dorssers, Stefan J. White, Leendert H. J. Looijenga

Abstract: BackgroundOriginating from Primordial Germ Cells/gonocytes and developing via a precursor lesion called Carcinoma In Situ (CIS), Germ Cell Cancers (GCC) are the most common cancer in young men, subdivided in seminoma (SE) and non-seminoma (NS). During physiological germ cell formation/maturation, epigenetic processes guard homeostasis by regulating the accessibility of the DNA to facilitate transcription. Epigenetic deregulation through genetic and environmental parameters (i.e. genvironment) could disrupt emb…

expand abstract