Seminal Vitamin B12 and Sterility

Furnass, S.B.

doi:10.1016/s0140-6736(63)91195-4

Cited by 9 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This contrasts with results obtained in other species, in which the use of cobalamin improved seminal parameters in humans and in bulls (BLAIR et al, 1968;BOXMEER et al, 2009;FURNASS, 1963;SCHMID et al, 2012;WATSON, 1962;WONG et al, 2002). This, perhaps, is due to the fact that the stallions used in this study were young, fertile stallions , with good semen quality.…”

Section: Discussioncontrasting

confidence: 98%

“…The prolonged use of Catosal B12® is not known to affect spermatogenesis and male fertility. Studies in different species have shown the importance of cobalamin on spermatogenesis and its positive effects on seminal quality; however, no studies have been performed in stallions (BLAIR et al, 1968;BOXMEER et al, 2009;FURNASS, 1963;SCHMID et al, 2012;WATSON, 1962;WONG et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of intramuscular injection of butafosfan and cobalamin on the quality of Fresh and Cooled Stallion Semen

et al. 2015

View full text Add to dashboard Cite

The use of butafosfan in combination with cobalamin modulates many cellular metabolic functions in several species. Its use enhances productive and reproductive performance and reduces stress responses in animals. Despite all these attributes, so far there have been no controlled studies to evaluate the effects of butafosfan and cobalamin on the quality of stallion semen. The purpose of this study was to evaluate the action of butafosfan in combination with cobalamin on the quality of fresh and cooled stallion semen. Four healthy stallions were kept in the same place and under the same management conditions during the entire experiment. Stallions were randomly assigned to two treatment groups in a 2x2 crossover design. Group A stallions were treated with an intramuscular injection of butafosfan twice a week for 80 days, while group B did not receive any treatment. After that, both groups were not treated for another 80 days allowing a washout period for the treated group. Then, the groups were reversed, and group B was treated with butafosfan and group A acted as the control for another 80 days. Semen was collected twice a week, diluted in skim milk and evaluated for total sperm count, total and progressive sperm motility, membrane integrity (CFDA/PI staining) and membrane functionality (HOS test) at 0 and 24 hours after preservation at 5ºC. Data were analyzed by comparing the values obtained from the treated stallions between the 60 th and 84 th days of treatment and the values obtained from the same stallion during the control period. The ejaculates of the washout period and between days 1 and 63 of treatment were not considered. A total of 85 ejaculates were analyzed by one-way ANOVA. Means were compared by the Tukey test at the 5% level of significance. No significant differences were observed in fresh and cooled semen regarding the total sperm count, total motility, progressive motility, membrane integrity and membrane functionality in the treated and control groups respectively. No interactions were detected in the fresh and cooled semen. The use of butafosfan and cobalamin in the stallions did not affect the seminal quality of young and fertile stallions. It can be used routinely and safely in these stallions. However, contrary to observations in humans and in bulls, the use of cobalamin did not improve semen parameters in these stallions. ResumoA utilização de Butafosfan em combinação com cobalamina modula uma série de funções metabólicas celulares em várias espécies. Seu uso melhora o desempenho produtivo e reprodutivo e reduz as respostas ao estresse em animais. Apesar de todos esses atributos, até agora não houve estudos controlados para avaliar os efeitos da substância Butafosfan e cobalamina sobre a qualidade do sêmen de garanhões. O objetivo deste estudo foi avaliar a ação do Butafosfan em combinação com cobalamina sobre a qualidade do sêmen fresco e resfriado de garanhões. Quatro garanhões saudáveis foram mantidos no mesmo lugar e sob as mesmas condições de manejo durante todo o experimen...

show abstract

Section: Discussioncontrasting

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Effect of intramuscular injection of butafosfan and cobalamin on the quality of Fresh and Cooled Stallion Semen

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Clinical observations have implicated cobalamin (vitamin B12) as an important nutrient for maintaining normal fertility in both sexes (1)(2)(3)(4)(5). However, little is known about its status or transport in the reproductive tract.…”

Section: Introductionmentioning

confidence: 99%

Transcobalamin II in human seminal plasma.

Carmel¹,

Bernstein²

1984

J. Clin. Invest.

View full text Add to dashboard Cite

Abstract. Study of cobalamin-binding proteins revealed seminal plasma to be the most concentrated site of transcobalamin II in man. The next richest normal fluid, blood, has approximately one-tenth its concentration. Normal seminal unsaturated cobalamin-binding capacity averaged 15,030±7,290 pg/ml, of which 11,550±6,660 pg/ml was transcobalamin II. Transcobalamin II levels were markedly diminished in subjects lacking seminal vesicles (1520-1660 pg/ml), but not after vasectomy. This suggests that seminal vesicles are the chief source of this protein in semen. R binder concentration was increased in postvasectomy subjects (9,970±4,900 pg/ml vs. 2,980±1,370 pg/ml in normals) and varied in other patients. The endogenous cobalamin content of semen was only 88-699 pg/ml, and was carried largely by R binder rather than by transcobalamin II. The function of the unusually large seminal transcobalamin II pool in reproduction is unknown, but seems unlikely to be related solely to cobalamin transport needs, at least within the male reproductive tract itself.

show abstract

Impact of Malnutrition on Reproductive Endocrinology

Brasel

1978

Nutrition and Human Reproduction

View full text Add to dashboard Cite

Seminal Vitamin B12 and Sterility

Cited by 9 publications

References 0 publications

Effect of intramuscular injection of butafosfan and cobalamin on the quality of Fresh and Cooled Stallion Semen

Effect of intramuscular injection of butafosfan and cobalamin on the quality of Fresh and Cooled Stallion Semen

Transcobalamin II in human seminal plasma.

Impact of Malnutrition on Reproductive Endocrinology

Contact Info

Product

Resources

About