Seminal Plasma Levels of Neutral Alpha Glucosidase Activity and Its Interactions with Spermiogram in Nigerian Males

Azenabor, Alfred; Ezeafulukwe, Jecinta; Ekun, Ayodele Oloruntoba; Bamiro, Babajide S.

doi:10.9734/arrb/2016/22765

Cited by 2 publications

(4 citation statements)

References 8 publications

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“…Our findings are consistent with the hypothesis that NAG activity in semen might be detectable earlier than spermatozoa after surgery. Our data also show that NAG activity has a moderate positive relationship with TMSC, possibly because NAG activity may reflect patency between the epididymis and vas deferens, epididymal function (Azenabor et al, ) and infection of the reproductive tract (Watanabe et al, ). Elevated NAG activity after MVE may indicate good patency, normal epididymal function and the absence of a serious reproductive tract infection.…”

Section: Discussionsupporting

confidence: 60%

“…Seminal plasma neutral alpha‐glucosidase (NAG) is mainly secreted by epididymal epithelial cells and is a specific epididymal enzyme marker (Guerin, Ali, Rollet, Souchier, & Czyba, ). Its activity is considered a reliable parameter for evaluating epididymal function and patency (Azenabor, Ezeafulukwe, Ekun, & Bamiro, ). Low NAG activity may reflect varying degrees of epididymal obstruction or epididymal hypofunction (Cooper, Yeung, Nashan, & Nieschlag, ).…”

Section: Introductionmentioning

confidence: 99%

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Seminal plasma neutral alpha‐glucosidase activity as an early predictor of patency and natural pregnancy after microsurgical vasoepididymostomy

Zhang

et al. 2019

Andrologia

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Microsurgical vasoepididymostomy (MVE) is recommended as a first-line option for treatment of epididymal obstructive azoospermia (EOA). However, early indicators for predicting patency and natural pregnancy are unclear. Our aim was to explore the early predictive value of seminal plasma neutral alpha-glucosidase (NAG) activity for patency and natural pregnancy after MVE. Eighty-four patients with EOA who underwent MVE were enrolled in this study. The post-operative patency and natural pregnancy rates were 60.71% and 33.33% respectively. The presence of motile epididymal spermatozoa at the anastomosis site and NAG activity measured at the first month after MVE were early and independent predictors of patency and natural pregnancy. The areas under the receiver operating characteristic curves (AUCs) of NAG activity for prediction of patency and natural pregnancy were 0.78 (95% confidence interval [CI]: 0.68-0.88) and 0.82 (95% CI: 0.73-0.92). The best cut-off values of NAG activity for predicting patency and pregnancy were 15.9 and 17.0 m IU/ejaculate respectively. In conclusion， NAG activity measured at the first month after MVE is an early and independent predictor of patency and natural pregnancy. K E Y W O R D Sneutral alpha-glucosidase, patency, pregnancy, vasoepididymostomy

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Seminal plasma neutral alpha‐glucosidase activity as an early predictor of patency and natural pregnancy after microsurgical vasoepididymostomy

Zhang

et al. 2019

Andrologia

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“…Neutral alpha-glucosidase (NAG), a particular epididymal enzyme marker, is mostly released by epididymal epithelial cells in seminal plasma (4) . Its activity is regarded as a trustworthy indicator for assessing epididymal patency and function (5) . Alpha-glucosidase, fructose, and zinc levels in seminal plasma are all considerably lower in male reproductive tract infections, indicating a possible impairment of the epididymis, seminal vesicles, and prostate's secretory function (6) .…”

Section: Introductionmentioning

confidence: 99%

“…Neutral alpha-glucosidase (NAG), a particular epididymal enzyme marker, is mostly released by epididymal epithelial cells in seminal plasma (4) . Its activity is regarded as a trustworthy indicator for assessing epididymal patency and function (5) . Traditional sperm parameters (8) , seminal ATP levels, and spermatozoa's ability to fertilise (9) , as well as reactive oxygen species (ROS) levels and peroxidase-positive white blood cell concentrations, which both negatively influence fertilisation, are negatively connected with NAG activity (10) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Genital Tract Infection on Alpha Glucosidase Enzyme in Semen of Infertile Male Patients

Shiha¹,

Elhanbly²,

State³

2023

The Egyptian Journal of Hospital Medicine

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Background: Certain biological substances could be thought of as reliable predictors of male infertility. An epididymal pathology might be evaluated with the use of the glucosidase determination. Reduced levels of glucosidase in semen have been linked to impaired sperm maturation in the epididymis and may possibly be connected to epididymitis and genital tract inflammation.Objective: This study aimed to assess how genital tract infections affected the amount of alpha glucosidase in infertile men's semen. Patients and methods: Thirty-one infertile male patients with pyospermia were included in this prospective study.

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Seminal Plasma Levels of Neutral Alpha Glucosidase Activity and Its Interactions with Spermiogram in Nigerian Males

Cited by 2 publications

References 8 publications

Seminal plasma neutral alpha‐glucosidase activity as an early predictor of patency and natural pregnancy after microsurgical vasoepididymostomy

Seminal plasma neutral alpha‐glucosidase activity as an early predictor of patency and natural pregnancy after microsurgical vasoepididymostomy

Effect of Genital Tract Infection on Alpha Glucosidase Enzyme in Semen of Infertile Male Patients

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