Seminal megavesicle in autosomal dominant polycystic kidney disease

MRI in autosomal dominant polycystic kidney disease

“…More recent studies, using high‐resolution T 2 ‐weighted MRI, revealed that seminal vesicle (SV) cysts in ADPKD reported on ultrasound and CT are actually dilated seminal vesicles, or "megavesicles" when they exceed 10 mm in diameter (Fig. ) . A study of 92 male ADPKD subjects and matched controls showed that megavesicles can occur together with dilated vas deferens and midline prostate cysts posterior to the verumontanum, where the ejaculatory ducts join to enter the urethra.…”

Relationship of Seminal Megavesicles, Prostate Median Cysts, and Genotype in Autosomal Dominant Polycystic Kidney Disease

“…). Megavesicles were defined by dilatation of the SV convoluted tubule ≥10 mm without visualization of any normal septum . All prostate cysts were categorized as located: 1) in the midline posterior to the prostatic urethra at the base of the prostate gland where they might cause obstruction of ejaculatory ducts, or 2) elsewhere in the prostate gland.…”

“…Megavesicles were defined by dilatation of the SV convoluted tubule ≥10 mm without visualization of any normal septum. 12 All prostate cysts were categorized as located: 1) in the midline posterior to the prostatic urethra at the base of the prostate gland where they might cause obstruction of ejaculatory ducts, or 2) elsewhere in the prostate gland. To assess changes in SV lumen diameter over time, ADPKD subjects with multiple MRIs (15 with megavesicles, 38 with SV <10 mm with 46 ± 23 months mean interval from first to final MRI) were examined to determine if any developed megavesicles over time or if any megavesicles reduced to under 10 mm lumen diameter over time.…”

“…We recently noticed that prostate cysts in ADPKD are mostly midline near the verumontanum where ejaculatory ducts join together to insert into the urethra. SV cysts in ADPKD reported by ultrasound and computed tomography (CT) are actually dilated SVs or "megavesicles" on higher‐resolution T 2 ‐weighted MRI . We hypothesized that prostate cysts related to ADPKD occur in the posterior prostate where ejaculatory ducts insert into the urethra, and are associated with dilatation of SVs and megavesicles.…”

“…SV cysts in ADPKD reported by ultrasound 10 and computed tomography (CT) 11 are actually dilated SVs or "megavesicles" on higher-resolution T 2weighted MRI. 12 We hypothesized that prostate cysts related to ADPKD occur in the posterior prostate where ejaculatory ducts insert into the urethra, and are associated with dilatation of SVs and megavesicles. We further hypothesized that megavesicles may help identify the probability of a mutation in PKD1 vs. PKD2.…”