Seminal extracellular vesicles alter porcine in vitro fertilization outcome by modulating sperm metabolism

Barranco, Isabel; Spinaci, Marcella; Nesci, Salvatore; Mateo-Otero, Yentel; Baldassarro, Vito Antonio; Algieri, Cristina; Bucci, Diego; Roca, Jordi

doi:10.1016/j.theriogenology.2024.02.024

Theriogenology

2024

DOI: 10.1016/j.theriogenology.2024.02.024

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Seminal extracellular vesicles alter porcine in vitro fertilization outcome by modulating sperm metabolism

Isabel Barranco,

Marcella Spinaci,

Salvatore Nesci

et al.

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2024

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Cited by 2 publications

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Swine in vitro embryo production: Potential, challenges, and advances

Garcia-Canovas,

Parrilla,

Cuello

et al. 2024

Animal Reproduction Science

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Swine in vitro embryo production: Potential, challenges, and advances

Garcia-Canovas,

Parrilla,

Cuello

et al. 2024

Animal Reproduction Science

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Small and Large Extracellular Vesicles of Porcine Seminal Plasma Differ in Lipid Profile

Martínez-Díaz,

Parra,

Sanchez-López

et al. 2024

IJMS

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Seminal plasma contains a heterogeneous population of extracellular vesicles (sEVs) that remains poorly characterized. This study aimed to characterize the lipidomic profile of two subsets of differently sized sEVs, small (S-) and large (L-), isolated from porcine seminal plasma by size-exclusion chromatography and characterized by an orthogonal approach. High-performance liquid chromatography–high-resolution mass spectrometry was used for lipidomic analysis. A total of 157 lipid species from 14 lipid classes of 4 major categories (sphingolipids, glycerophospholipids, glycerolipids, and sterols) were identified. Qualitative differences were limited to two cholesteryl ester species present only in S-sEVs. L-sEVs had higher levels of all quantified lipid classes due to their larger membrane surface area. The distribution pattern was different, especially for sphingomyelins (more in S-sEVs) and ceramides (more in L-sEVs). In conclusion, this study reveals differences in the lipidomic profile of two subsets of porcine sEVs, suggesting that they differ in biogenesis and functionality.

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Seminal extracellular vesicles alter porcine in vitro fertilization outcome by modulating sperm metabolism

Cited by 2 publications

References 67 publications

Swine in vitro embryo production: Potential, challenges, and advances

Swine in vitro embryo production: Potential, challenges, and advances

Small and Large Extracellular Vesicles of Porcine Seminal Plasma Differ in Lipid Profile

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