Seminal Cytology in the Presence of Varicocele

MacLeod, John

doi:10.1016/s0015-0282(16)35765-x

Cited by 387 publications

(105 citation statements)

References 9 publications

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“…Each year -20,000 men undergo varicocelectomy in hopes of eliminating a lesion about which little is known. The bilateral, deleterious effects of the unilateral lesion on testicular histology and semen are well described (2,3). Elevated testicular temperature, reflux of adrenal or renal metabolites, hypoxia secondary to venous stasis, and hormonal imbalance have been proposed as mechanisms through which spermatogenesis is impaired.…”

mentioning

confidence: 99%

Influence of surgically induced varicocele on testicular blood flow, temperature, and histology in adult rats and dogs.

Saypol¹,

Howards²,

Turner³

et al. 1981

J. Clin. Invest.

244

131

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A B S T R A C T Varicocele has been repeatedly implicated as a cause of infertility in selected men, although neither a causal relationship nor a mechanism has been documented. The purpose of this investigation was to create a varicocele model in animals and to study the subsequent alterations in testicular physiology. Secondary dilatation of the left internal spermatic vein was achieved either by partial ligation ofthe left renal vein in rats and dogs or by surgical destruction of the valve of the left testicular vein in a second group of dogs.

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mentioning

confidence: 99%

Influence of surgically induced varicocele on testicular blood flow, temperature, and histology in adult rats and dogs.

Saypol¹,

Howards²,

Turner³

et al. 1981

J. Clin. Invest.

244

131

View full text Add to dashboard Cite

show abstract

“…These abnormalities can occur in isolation or in combination (known as oligoasthenoteratospermia or OAT syndrome). This effect was first described in 1965 by MacLeod, [7] who described the above seminal abnormalities in patients with varicocele.…”

mentioning

confidence: 81%

Clinical Study of Management of Varicocele

Sekhar¹,

Rao²

2017

jemds

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“…In clinical practice, most reports show persistent abnormality of sperm count, motility, or morphology [8]. The "stress pattern," which consists of elongated, tapered sperm head and amorphous cells, is commonly, though not consistently, attributed to varicocele patients [9].…”

Section: Introductionmentioning

confidence: 99%

Varicocele and Male Infertility: Current Issues in Management-A Review

Sv¹

2014

Med Surg Urol

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Varicocele is the most common correctable cause of male factor infertility. The role of varicocele in the etiology of male infertility is still controversial regarding to whom varicocelectomy should be done and the selection should be meticulous. With the recent advances in biomolecular and development of novel sperm functional tests, it has been possible to better understand the mechanism involved in damage provoked by varicocele and therefore, propose ways to reverse them. Clinical studies have shown that varicocele surgery can improve semen quality sufficient to downgrade the type of assisted reproductive technology (ART) procedure required. This reveiw discusses current concepts on the mechanisms for varicocele induced testicular damage and efficacy of varicocelectomy for treatment of infertility. We also review the current guidelines and need for proper case selection before surgery.The authors critically reviewed the cost effectiveness of the surgical treatment of a varicocele compared with assisted reproductive techniques.

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Seminal Cytology in the Presence of Varicocele

Cited by 387 publications

References 9 publications

Influence of surgically induced varicocele on testicular blood flow, temperature, and histology in adult rats and dogs.

Influence of surgically induced varicocele on testicular blood flow, temperature, and histology in adult rats and dogs.

Clinical Study of Management of Varicocele

Varicocele and Male Infertility: Current Issues in Management-A Review

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