Seminal and serum leptin levels in male patients with varicocele and isolated asthenozoospermia before and after repair

Taieb, Moustafa A El; Hegazy, Eisa M.; Ibrahim, Hassan; Ibrahim, Ahmed K.

doi:10.1080/13685538.2018.1548590

Cited by 8 publications

(6 citation statements)

References 36 publications

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“…Suggested pathomechanism related to agedependent changes in the male reproductive system Like the effect of aging on male reproductive potential, the pathomechanism responsible for age-dependent patterns of decline in semen quality is not easy to establish [7,58,59]. It is known that these changes may result from age: 1) vascular insufficiency [60][61][62], 2) systemic diseases (e.g. diabetes, hypertension) [60,61], 3) chronic infections (e.g.…”

Section: Discussionmentioning

confidence: 99%

Male aging as a causative factor of detrimental changes in human conventional semen parameters and sperm DNA integrity

et al. 2020

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The effect of male aging on fertility potential is controversial and difficult to predict. The aim of our study was to determine the associations between age, basic semen parameters, and sperm DNA fragmentation (SDF). Comparison of four age-dependent groups (men 29 years, 30-35 years, 36-40 years, and >40 years) revealed a significant fall in the basic semen characteristics and sperm genomic integrity with age. Receiver operating characteristic (ROC) analysis confirmed that men >29 years had lower semen quality. In the group of men >29 years, the prevalence of men with abnormal semen parameters was higher, and these men had over a threefold higher odds ratio (OR) for abnormal semen parameters. Next, ROC analysis revealed that a threshold of 18% SDF was optimal for discriminating between men with normal and abnormal standard semen parameters. The prevalence of men with >18% SDF was higher in the group of men >29 years than in men 29 years. Older men had an almost twofold higher risk for >18% SDF than younger men. Our results suggest that age >29 years may be a causative factor of detrimental changes in semen quality, which may raise the risk for disorders of male fertility potential.

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Section: Discussionmentioning

confidence: 99%

Male aging as a causative factor of detrimental changes in human conventional semen parameters and sperm DNA integrity

et al. 2020

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“…Despite published studies reporting low testosterone level related to varicocele, Panach-Navarrete et al reported no relationship between presence of varicocele and low testosterone level in a multivariate analysis, however, they found that obesity and older age were significantly related to low levels of total and free testosterone [21]. In addition, for the first time, presence of varicocele was demonstrated as the association with higher levels of seminal and serum leptin, and these levels significantly decreased after varicocele repair [22]. In addition to varicocele, older male age (!45 years) is associated with increased sperm DNA fragmentation and chromatin integrity, leading to negative impact on semen quality and fertility [23].…”

Section: Discussionmentioning

confidence: 94%

Effect of microsurgical varicocele repair on sexual functions and testosterone in hypogonadal infertile men with varicocele

2020

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Objective: To investigate effect of microsurgical varicocele repair on sexual functions and serum total testosterone level in infertile hypogonadal men with varicocele, and also to determine factors that might predict improvement in total testosterone level after surgery. Methods: The study included 202 infertile hypogonadal men (total testosterone level of <3.5 ng/mL) with varicocele who underwent microsurgical sub-inguinal varicocele repair. Results: Mean serum total testosterone level significantly increased from 2.55 ± 0.66 ng/mL to 3.72 ± 1.34 ng/mL after varicocelectomy (p ¼ .000), and 105 patients (52%) had serum total testosterone level of !3.5 ng/mL after the surgery. Mean international index of erectile functions (IIEF-EF) score significantly increased from 27.47 ± 2.96 to 28.61 ± 2.02, post-operatively (p ¼ .000). Of the patients who had pre-operative IIEF-EF score of 26, 65.5% had IIEF-EF score of !26 after varicocelectomy. Of the patients who had pre-operative decreased libido, 86.6% had postoperative increased libido. Only older patient age was the predictor for having total testosterone level of !3.5 ng/mL after the surgery (p ¼ .031). Conclusions: Data suggest that serum total testosterone level, IIEF-EF score and sexual libido significantly increase after varicocele surgery. As the age increases, total testosterone level increased after varicocele surgery. Therefore, varicocele repair could be offered to hypogonadal men with clinically varicocele.

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“…For instance, the level of leptin in the semen of varicocele patients was significantly higher than that in the normal subjects. The seminal leptin content was positively correlated with varicocele classification and inversely proportional to sperm motility ( Ishikawa et al, 2007 ; Chen et al, 2009 ; El Taieb et al, 2019 ). But the controversial case was also reported.…”

Section: Discussionmentioning

confidence: 99%

Presence of leptin and its receptor in the ram reproductive system and in vitro effect of leptin on sperm quality

Gao

Zhao

Song

et al. 2022

PeerJ

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Leptin is a 16 kDa hormone encoded by obese (OB) gene in adipocytes. This molecule not only regulates energy metabolism but also plays a role in the reproduction of mammals. Leptin and its receptor (OBR) have been found in male reproductive systems of human, bovine, equine and pig. The effects of leptin on sperm quality vary widely from different research findings. However, the presence of leptin and its receptor in the ram reproductive system and the in vitro effect of leptin on sperm quality have not reported yet. In the present study, we found that the OB was highly expressed in primary and secondary spermatocytes of the testes, OBR was highly expressed in secondary spermatocytes of the testes. The expressions of OB were in stereocilia of epididymis and in columnar cells of epididymal caput and cauda, the expressions of OBR were in columnar cells of epididymis and in stereocilia of epididymal corpus and cauda. The presence of both OB and OBR in testes, epididymis and sperm were confirmed through RT-PCR, immunolocalization and Western blot analyses. The RT-qPCR results indicated OB and OBR had higher expression levels in epididymal sperm than that of the ejaculated sperm in rams. When sperm were treated with 5 ng/mL leptin, the progressive motility (P < 0.01), straight-line velocity (VSL) (P < 0.05), average path velocity (VAP) (P < 0.05), membrane mitochondrial potential (MMP) (P < 0.01) and viability (P < 0.05) significantly increased, while DNA fragmentation index (DFI) and reactive oxygen species (ROS) significantly decreased compared to the control (P < 0.01), and the other semen parameters such as acrosome integrity and acrosome reaction rate had no significant changes between groups (P > 0.05). In conclusion, this is probably the first report describing localization of leptin and its receptors in the reproductive system of rams and their effects on sperm quality parameters. Our findings suggest that 5 ng/mL leptin treatment enhanced sperm motility, viability and MMP, and decrease DFI and ROS without obvious influence on the acrosome reaction in ram sperm. The potential mechanisms may be related to leptin’s ability to reduce the oxidative stress and apoptosis of sperms and improve their mitochondrial function and energy supply, therefore, to maintain the physiological homeostasis of the sperm.

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Seminal and serum leptin levels in male patients with varicocele and isolated asthenozoospermia before and after repair

Cited by 8 publications

References 36 publications

Male aging as a causative factor of detrimental changes in human conventional semen parameters and sperm DNA integrity

Male aging as a causative factor of detrimental changes in human conventional semen parameters and sperm DNA integrity

Effect of microsurgical varicocele repair on sexual functions and testosterone in hypogonadal infertile men with varicocele

Presence of leptin and its receptor in the ram reproductive system and in vitro effect of leptin on sperm quality

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