Semiconductor Work, Leukemia, and Cancer Risk: A Systematic Review and Meta-Analysis

Kim, Kyungsik; Sung, Hwa Jung; Lee, Kwan; Park, Sue Kyung

doi:10.3390/ijerph192214733

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…This issue is reflected in the role of clinicians who need to have multilevel competences. Finally, it should be noted that novel materials, among which semiconductors, appear to be safe for workers and are not clearly associated with a specific risk of cancer development [ 292 , 293 , 294 ]; however, adequate control exposure and monitoring programs should be applied by global agencies.…”

Section: Discussionmentioning

confidence: 99%

Smart Sensors and Microtechnologies in the Precision Medicine Approach against Lung Cancer

et al. 2023

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Background and rationale. The therapeutic interventions against lung cancer are currently based on a fully personalized approach to the disease with considerable improvement of patients’ outcome. Alongside continuous scientific progresses and research investments, massive technologic efforts, innovative challenges, and consolidated achievements together with research investments are at the bases of the engineering and manufacturing revolution that allows a significant gain in clinical setting. Aim and methods. The scope of this review is thus to focus, rather than on the biologic traits, on the analysis of the precision sensors and novel generation materials, as semiconductors, which are below the clinical development of personalized diagnosis and treatment. In this perspective, a careful revision and analysis of the state of the art of the literature and experimental knowledge is presented. Results. Novel materials are being used in the development of personalized diagnosis and treatment for lung cancer. Among them, semiconductors are used to analyze volatile cancer compounds and allow early disease diagnosis. Moreover, they can be used to generate MEMS which have found an application in advanced imaging techniques as well as in drug delivery devices. Conclusions. Overall, these issues represent critical issues only partially known and generally underestimated by the clinical community. These novel micro-technology-based biosensing devices, based on the use of molecules at atomic concentrations, are crucial for clinical innovation since they have allowed the recent significant advances in cancer biology deciphering as well as in disease detection and therapy. There is an urgent need to create a stronger dialogue between technologists, basic researchers, and clinicians to address all scientific and manufacturing efforts towards a real improvement in patients’ outcome. Here, great attention is focused on their application against lung cancer, from their exploitations in translational research to their application in diagnosis and treatment development, to ensure early diagnosis and better clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Smart Sensors and Microtechnologies in the Precision Medicine Approach against Lung Cancer

et al. 2023

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“…Over several decades, the potential hazards of the semiconductor industry have increased, but epidemiological studies have reported no significant excess cancer incidence or mortality among semiconductor workers in the United Kingdom (UK), the United States (US), Taiwan, and South Korea [ 12 – 16 ]. A systematic review and meta-analysis also reported no significant association between semiconductor work and leukemia [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Lymphohematopoietic cancer mortality among Korean semiconductor manufacturing workers

2023

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Background We aimed to examine the lymphohematopoietic cancer mortality in a cohort of workers at a semiconductor manufacturing company in South Korea according to their jobs. Methods A retrospective cohort was constructed using the personnel records of semiconductor manufacturing workers who were employed in a semiconductor company in South Korea in 1998–2012. Data on their vital status and causes of death were obtained from the National Statistical Office of South Korea. The standardized mortality ratios (SMRs) of lymphohematopoietic cancer were calculated. Results A total of 288 deaths were reported, of which 22 were caused by lymphohematopoietic cancer, among 65,782 workers in 878,325 person-years. The SMRs for lymphohematopoietic cancer were 0.78 (95% confidence interval [CI] = 0.39–1.40; the number of observed cases [Obs] = 11) among male workers and 1.71 (95% CI = 0.85–3.06; Obs = 11) among female workers. Among female operators, excess deaths due to lymphohematopoietic cancer (SMR = 2.59, 95% CI = 1.24–4.76) and leukemia (SMR = 2.92, 95% CI = 1.26–5.76) were observed. However, they were not observed among office workers, facility managers, utility managers, or process managers. Conclusion Female operators involved in the semiconductor wafer fabrication process had higher risk of mortality from lymphohematopoietic cancer.

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Please Give Me a Remedy: Women Human Rights Defenders Mobilize for Occupational Safety and Health

Nissen

2024

Journal of Human Rights Practice

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Semiconductor Work, Leukemia, and Cancer Risk: A Systematic Review and Meta-Analysis

Cited by 3 publications

References 29 publications

Smart Sensors and Microtechnologies in the Precision Medicine Approach against Lung Cancer

Smart Sensors and Microtechnologies in the Precision Medicine Approach against Lung Cancer

Lymphohematopoietic cancer mortality among Korean semiconductor manufacturing workers

Please Give Me a Remedy: Women Human Rights Defenders Mobilize for Occupational Safety and Health

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