Semiautomatic Analysis of Phase Contrast Magnetic Resonance Imaging of Cerebrospinal Fluid Flow through the Aqueduct of Sylvius

Flórez, Yudy Natalia; Moratal, David; Forner, J.; Martí‐Bonmatí, Luis; Arana, Estanislao; Guajardo-Hernández, Ulises; Millet, José

doi:10.1007/s10334-006-0030-6

Cited by 29 publications

(22 citation statements)

References 28 publications

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“…Regrettably, in many other studies where CSF movement in the aqueduct of Sylvius has been examined in physiological conditions by different MR imaging techniques, the obtained results did not allow presentation of the rate of CSF formation (V f ) neither from reported flow values nor from the CSF velocity (Baledent et al, 2006;Barkhof et al, 1994;Florez et al, 2006;Kim et al, 1999;Lee et al, 2004;Luetmer et al, 2002;Mase et al, 1998;Schroeder et al, 2000;Scollato et al, 2008;Stahlberg et al, 1989). The reason for this lies in the fact that attempts have been made to diagnose pathologic changes by means of other, more easily measurable hydrodynamic parameters in the aqueduct of Sylvius (see above).…”

Section: Magnetic Resonance Imaging Methodsmentioning

confidence: 96%

“…Because the aqueduct has a constant diameter over a certain length, a rather constant flow pattern is present as opposed to, for example, the foramina of Monro where irregular flow patterns may be encountered. Cardiac cycle-related cerebral blood volume variations produce bidirectional oscillatory movement of CSF within the aqueduct (Barkhof et al, 1994;Florez et al, 2006;Greitz et al, 1993;Lee et al, 2004;Luetmer et al, 2002;Ohara et al, 1988). During systole, the net inflow of blood increases the intracranial volume and induces craniocaudal (systolic) CSF movement.…”

Section: Magnetic Resonance Imaging Methodsmentioning

confidence: 99%

“…This assumption has rarely been reported in literature (Di Chiro, 1964;Weed, 1914). It is believed that CSF flow is augmented by the ciliary action of the ventricular ependyma, vascular, choroidal and respiratory pulsations, cardiac systole and diastole and the hydrostatic pressure gradient that exists between the CSF and the venous system (Bering, 1962;Bering and Satto, 1963;Bhadelia et al, 1995;Di Chiro, 1964;Du Boulay, 1966;Du Boulay et al, 1972;Florez et al, 2006;Lee et al, 2004;Mascalchi et al, 1988;Milhorat, 1975;O'Connel, 1970;Ohara et al, 1988;Scollato et al, 2008;Thomsen et al, 1990).…”

Section: Formation Rate Of Cerebrospinal Fluid As the Main Generator mentioning

confidence: 99%

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The formation of cerebrospinal fluid: Nearly a hundred years of interpretations and misinterpretations

Orešković

Klarica

2010

Brain Research Reviews

296

274

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Section: Magnetic Resonance Imaging Methodsmentioning

confidence: 96%

Section: Magnetic Resonance Imaging Methodsmentioning

confidence: 99%

Section: Formation Rate Of Cerebrospinal Fluid As the Main Generator mentioning

confidence: 99%

See 1 more Smart Citation

The formation of cerebrospinal fluid: Nearly a hundred years of interpretations and misinterpretations

Orešković

Klarica

2010

Brain Research Reviews

296

274

View full text Add to dashboard Cite

“…CSF flow data were processed using GE ReportCard software (v. 3.6; General Electric) and peak positive and negative velocities for each phase were recorded. Two of the ReportCard software limitations are: using a manually, operator-dependent segmented ROI in quantifying flow (which results in large variability of the flow rates measured (7,15)); and using this single, stationary ROI for all phases of the cine PC acquisition. Consequently, a semiautomated Minimum Area Contour Change (MACC) program was designed to correct the ROIs for each phase, as previously described (11,14).…”

Section: Cine Phase Contrast Image Analysismentioning

confidence: 99%

“…Cine phase contrast MRI has been previously used for CSF flow quantification in healthy controls (HC), patients with hydrocephalus, stroke patients, the elderly, etc (6)(7)(8)(9).…”

mentioning

confidence: 99%

Cine cerebrospinal fluid imaging in multiple sclerosis

Magnano

Schirda

Weinstock‐Guttman

et al. 2012

Magnetic Resonance Imaging

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Purpose: To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius in multiple sclerosis (MS) patients and healthy controls (HC) using cine phase contrast imaging. Materials and Methods:In all, 67 MS patients (48 relapsing-remitting [RR] and 19 secondary-progressive [SP]), nine patients with clinically isolated syndrome (CIS), and 35 age-and sex-matched HC were examined. CSF flow and velocity measures were quantified using a semiautomated method and compared with clinical and magnetic resonance imaging (MRI) disease outcomes.Results: Significantly decreased CSF net flow was detected in MS patients compared to HC (À3.7 vs. À7.1 mL/beat, P ¼ 0.005). There was a trend for increased net positive flow between SP, RR, and CIS patients. Altered CSF flow and velocity measures were associated with more severe T1 and T2 lesion volumes, lateral and fourth ventricular volumes, and third ventricular width in MS and CIS patients (P < 0.01 for all). In CIS patients, conversion to clinically definite MS in the following year was related to decreased CSF net flow (P ¼ 0.007). There was a trend between increased annual relapse rate and altered CSF flow/velocity measures in RRMS patients (P < 0.05).Conclusion: CSF flow dynamics are altered in MS patients. More severe clinical and MRI outcomes in RRMS and CIS patients relate to altered CSF flow and velocity measures.

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Cerebrospinal Fluid Flow in Patients with Huntington's Disease

Hett

Eisma

Hernandez

et al. 2023

Annals of Neurology

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ObjectiveInvestigations of cerebrospinal fluid (CSF) flow aberrations in Huntington's disease (HD) are of growing interest, as impaired CSF flow may contribute to mutant Huntington retention and observed heterogeneous responsiveness to intrathecally administered therapies.MethodWe assessed net cerebral aqueduct CSF flow and velocity in 29 HD participants (17 premanifest and 12 manifest) and 51 age‐ and sex matched non‐HD control participants using 3‐Tesla magnetic resonance imaging methods. Regression models were applied to test hypotheses regarding: (i) net CSF flow and cohort, (ii) net CSF flow and disease severity (CAP‐score), and (iii) CSF volume after correcting for age and sex.ResultsGroup‐wise analyses support a decrease in net CSF flow in HD (mean 0.14 ± 0.27 mL/min) relative to control (mean 0.32 ± 0.20 mL/min) participants (p = 0.02), with lowest flow in the manifest HD cohort (mean 0.04 ± 0.25 mL/min). This finding was explained by hyperdynamic CSF movement, manifesting as higher caudal systolic CSF flow velocity and higher diastolic cranial CSF flow velocity across the cardiac cycle, in HD (caudal flow: 0.17 ± 0.07 mL/s, cranial flow: 0.14 ± 0.08 mL/s) compared to control (caudal flow: 0.13 ± 0.06 mL/s, cranial flow: 0.11 ± 0.04 mL/s) participants. A positive correlation between cranial diastolic flow and disease severity was observed (p = 0.02).InterpretationsFindings support aqueductal CSF flow dynamics changing with disease severity in HD. These accelerated changes are consistent with changes observed over the typical adult lifespan, and may have relevance to mutant Huntington retention and intrathecally administered therapeutics responsiveness. ANN NEUROL 2023

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Semiautomatic Analysis of Phase Contrast Magnetic Resonance Imaging of Cerebrospinal Fluid Flow through the Aqueduct of Sylvius

Abstract: Semiautomatic measurements (seed method with half moon background and aliasing correction) allow a generalization of the calculus of flow parameters with great consistency and independency of the operator.

Cited by 29 publications

References 28 publications

The formation of cerebrospinal fluid: Nearly a hundred years of interpretations and misinterpretations

The formation of cerebrospinal fluid: Nearly a hundred years of interpretations and misinterpretations

Cine cerebrospinal fluid imaging in multiple sclerosis

Cerebrospinal Fluid Flow in Patients with Huntington's Disease

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