Semiautomated Assay for Indapamide in Biological Fluids

Grebowx, Peter E.; Treitman, Jo A.; Yeung, Anne K.; Johnston, Martha M.

doi:10.1002/jps.2600700321

Cited by 12 publications

(1 citation statement)

References 3 publications

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“…The methods reported in literature for estimation of indapamide in whole blood [6,[8][9][10][11][12], serum [8,13,14], plasma [11,12], and urine [11,[15][16][17][18][19] involves use of HPLC, or in combination with MS, i.e. LC-MS/MS analytical techniques.…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatography–tandem mass spectrometry validated method for the estimation of indapamide in human whole blood

Jain

Subbaiah

Sanyal

et al. 2006

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Liquid chromatography–tandem mass spectrometry validated method for the estimation of indapamide in human whole blood

Jain

Subbaiah

Sanyal

et al. 2006

Journal of Chromatography B

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Electrochemical oxidation of the diuretic indapamide

1996

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The electrochemical oxidation of the D-(Aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-lH-indol-l-yl)benzamide, Indapamide, was studied in aqueous alcoholic media (9:91 MeOH+H20, pH range 1-13) and two different ionic media (KNO? and KCI) at carbon electrodes. The oxidation processes attributed to indoline ring and benzamide moiety have been shown to be irreversible and diffusioncontrolled over the entire pH range in both media. A differential-pulse voltammetric method was developed upon the basis of the voltammetric peak due to indoline ring, at pH around 2.3 (phosphate buffer) and using KN03 as ionic medium. The peak current i , showed a linear relationship with concentration in the range 5.92 x lo-' M-1.86 x lo-' M with a detection limit of 9.87 x lo-* M (37 ppb) and a reproducibility (in terms of relative standard deviation) of 4.8% and 9.3% for 10 determinations of 2.67 x IO-' M and 1.07 x M concentrations, respectively. The diKeerential-pulse voltammetric method for Indapamide was applied to assays of pharmaceuticals (Tertensif, 2.5 mg) and urine samples.

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The Disposition of ¹⁴C‐indapamide in Man

Klunk¹,

Ringel²,

Neiss³

1983

The Journal of Clinical Pharma

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The metabolism of 14C-indapamide labeled in the indoline ring was determined after a single oral administration of a solution (4.99 mg, 90.47 microCi) to four fasted adult male volunteers. 14C-Indapamide was rapidly absorbed, and peak blood concentrations of radioactivity occurred by 0.5 hour in three subjects and at 2 hours in one subject. The mean elimination half-lives of total radioactivity were 27.0 hours in blood and 24.5 hours in plasma. The concentration of total radioactivity in blood was 5.7 times greater than in plasma, indicating extensive binding to red blood cells. Unchanged drug, as analyzed in one subject, reached a peak concentration by 0.5 hour, and had a blood half-life of 15.8 hours. Radioactivity was primarily excreted in the urine, and more than 50 per cent of the administered radioactivity was eliminated by this route in 48 hours. By eight days, 92.8 per cent of the radioactivity was recovered, with 70.3 per cent in the urine and 22.5 per cent in the feces. 14C-Indapamide was shown to be extensively metabolized, with only 7.3 per cent of the dose excreted as unchanged drug in the urine. Systemic and renal clearances of total radioactivity were 12.8 +/- 1.3 and 8.6 +/- 0.8 ml/min, respectively, while the renal clearance of unchanged indapamide, determined for one subject, was substantially lower (1.71 ml/min).

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Semiautomated Assay for Indapamide in Biological Fluids

Cited by 12 publications

References 3 publications

Liquid chromatography–tandem mass spectrometry validated method for the estimation of indapamide in human whole blood

Liquid chromatography–tandem mass spectrometry validated method for the estimation of indapamide in human whole blood

Electrochemical oxidation of the diuretic indapamide

The Disposition of ¹⁴C‐indapamide in Man

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Semiautomated Assay for Indapamide in Biological Fluids

Cited by 12 publications

References 3 publications

Liquid chromatography–tandem mass spectrometry validated method for the estimation of indapamide in human whole blood

Liquid chromatography–tandem mass spectrometry validated method for the estimation of indapamide in human whole blood

Electrochemical oxidation of the diuretic indapamide

The Disposition of 14C‐indapamide in Man

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The Disposition of ¹⁴C‐indapamide in Man