Semi-standardised homeopathic treatment of premenstrual syndrome with a limited number of medicines: Feasibility study

Klein-Laansma, Christien; Jansen, Jennifer; Tilborgh, A.J.W. van; Windt, D.A.W.M. van der; Mathie, Robert T.; Rutten, A.L.B.

doi:10.1016/j.homp.2010.05.007

Cited by 7 publications

(6 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The design of the PMS homeopathic treatment protocol and its evaluation in the daily practice were published previously [10]. An expert panel selected 11 homeopathic medicines and defined 7-10 keynote symptoms for each homeopathic medicine.…”

Section: Methodsmentioning

confidence: 99%

“…For the homeopathic medicine selection, the algorithm produced a list with all homeopathic medicines that ended up within 20% of the highest-scoring medicine: the ‘top 20%'. If there was more than 1 medicine in the ‘top 20%', the doctor had to apply pre-selected ‘help' questions for each medicine [10]. …”

Section: Methodsmentioning

confidence: 99%

“…A detailed description of the measurement instruments that were used to evaluate results can be found in previous and simultaneous publications: study 1 [10,13] and study 2 (submitted for publication).…”

Section: Methodsmentioning

confidence: 99%

“…First, a reproducible, semi-standardized homeopathic treatment protocol was designed with 11 homeopathic medicines [10]. It comprised a ‘PMS homeopathic prognostic questionnaire' with keynote symptoms and an electronic algorithm (repertory).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of a Prognostic Homeopathic Questionnaire for Women with Premenstrual Disorders

et al. 2018

View full text Add to dashboard Cite

Background/Aims: Validation of treatments with individually prescribed homeopathic medicines is a challenging task. A prognostic homeopathic patient questionnaire containing 140 keynote symptoms (highly characteristic of a specific homeopathic medicine) and an electronic algorithm to process the answers were used in 2 clinical studies. The algorithm outcome, based on total symptom scores, indicated 1 of 11 pre-selected homeopathic medicines for women with premenstrual syndrome and premenstrual dysphoric disorder (PMS/PMDD). Aims were (1) to estimate the prognostic values of keynote symptoms and (2) to evaluate the reliability of the homeopathic medicine ranking in the algorithm outcome. Methods: The prevalence of specific keynote symptoms was calculated in 145 women diagnosed with PMS/PMDD and in 40 included women with favorable outcomes using 1 of the 11 homeopathic medicines. Likelihood ratios (LRs) of the keynote symptoms were calculated. Pearson's correlations were calculated between 2 sets of total algorithm scores for 11 homeopathic medicines, obtained at 2 time points. Results: (1) A positive prognostic value (LR ≥ 1.5) was found in 34 keynote symptoms with a prevalence of 10-40%, with 10 symptoms already being connected to the corresponding homeopathic medicine in the algorithm. For example, the symptom ‘common cold of the nose before menstruation' indicated Magnesium carbonicum with LR = 7.47 (confidence interval (CI) 3.90-14.28). (2) Pearson's correlations for the reliability evaluation varied from 0.69 to 0.84. Conclusions: Recommendations can be made to improve the PMS algorithm with more accurate keynote symptoms. The prognostic questionnaire proved a reliable tool to rank 11 homeopathic medicines by total scores, based on keynote symptoms. This PMS algorithm can be used for the treatment of PMS/PMDD in clinical practice.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of a Prognostic Homeopathic Questionnaire for Women with Premenstrual Disorders

et al. 2018

View full text Add to dashboard Cite

show abstract

“…17,18 In recent years, a reproducible individualized treatment, similar to the one used in this study, was used for women with PMS, with beneficial results. [19][20][21] Placebo/Nocebo Effect In general a therapeutic relationship, with attention for personal needs, emotional support, and offering of possible solutions, can have an important placebo or context effect. 22,23 All women in this study had an intake visit in which these components were present.…”

Section: Reproducibilitymentioning

confidence: 99%

A Placebo-Controlled Double-Blind Randomized Trial with Individualized Homeopathic Treatment Using a Symptom Cluster Approach in Women with Premenstrual Syndrome

et al. 2019

View full text Add to dashboard Cite

Background In a double-blind placebo-controlled randomized trial with parallel groups, the efficacy of individually prescribed homeopathic medicines was evaluated in women with premenstrual syndrome (PMS). Methods In an outpatient department of a university clinic in Jerusalem, Israel (1996–1999), women with PMS, aged 18 to 50 years, entered a 2-month screening phase with prospective daily recording of premenstrual symptoms by the Menstrual Distress Questionnaire (MDQ). They were included after being diagnosed with PMS. A reproducible treatment protocol was used: women received a homeopathic prescription based on symptom clusters identified in a questionnaire. The symptoms were verified during a complementary, structured, interview. Only women whose symptoms matched the symptom profile of one of 14 pre-selected homeopathic medicines were included. Each participant was administered active medicine or placebo via random allocation. Primary outcome measures were differences in changes in mean daily premenstrual symptom (PM) scores by the MDQ. Analysis was by intention-to-treat. Results A total of 105 women were included: 49 were randomized to active medicine and 56 to placebo. Forty-three women in the active medicine group and 53 in the placebo group received the allocated intervention with at least one follow-up measurement and their data were analyzed. Significantly greater improvement of mean PM scores was measured in the active medicine group (0.443 [standard deviation, SD, 0.32] to 0.287 [SD, 0.20]) compared to placebo (0.426 [SD, 0.34] to 0.340 [SD, 0.39]); p = 0.043. Conclusions Individually prescribed homeopathic medicines were associated with significantly greater improvement of PM scores in women with PMS, compared to placebo. Replication, with larger sample size and other refinements, is recommended to confirm the efficacy of this treatment in other settings.

show abstract

Recommendations in the design and conduction of randomised controlled trials in human and veterinary homeopathic medicine

Gaertner

Ammon

Fibert

et al. 2023

Complementary Therapies in Medicine

View full text Add to dashboard Cite

Semi-standardised homeopathic treatment of premenstrual syndrome with a limited number of medicines: Feasibility study

Cited by 7 publications

References 28 publications

Evaluation of a Prognostic Homeopathic Questionnaire for Women with Premenstrual Disorders

Evaluation of a Prognostic Homeopathic Questionnaire for Women with Premenstrual Disorders

A Placebo-Controlled Double-Blind Randomized Trial with Individualized Homeopathic Treatment Using a Symptom Cluster Approach in Women with Premenstrual Syndrome

Recommendations in the design and conduction of randomised controlled trials in human and veterinary homeopathic medicine

Contact Info

Product

Resources

About