Semi-solid extrusion 3D printing of tailored ChewTs for veterinary use - A focus on spectrophotometric quantification of gabapentin

Compounding Tailored Veterinary Chewable Tablets Close to the Point-of-Care by Means of 3D Printing

“…The suitable moisture content of a tablet was found by Tomar et al to be around 4-5% [51]. In the current study, the average measured moisture content at the different stability study time points varied between 3.2% and 4.7%, which is in line with the study found by Tomar et al This is also in line with the previous study's findings [26].…”

“…The ink in the current study was prepared in the same manner as the formulation made by Sjöholm et al [ 26 ] in order to study the ability to utilize the same ink base in the preparation of drug-loaded inks containing different drugs. Hence, the only difference in the preparation was the addition of the active pharmaceutical ingredient (API).…”

“…After thoroughly mixing, a brown paste was obtained. The prepared printing ink was left to stand in 10 mL optimum clear barrel syringes with optimum clear pistons (both by Nordson EFD LLC, East Providence, RI, USA) for two hours prior to printing to remove any bubbles as well as let the ink settle as found in rheology results obtained in the previous study [ 26 ]. A drug-free placebo ink was prepared in the same manner as the drug-loaded ink without the addition of the API and was used as a reference in the performed analysis.…”

“…Lately, SSE 3D printing has gained interest as a manufacturing technique for the production of drug-loaded dosage forms. In addition to the TPH-containing dosage forms described above, the technique has been explored for the production of a variety of drug delivery systems, such as tablets with high drug-loading [ 18 ], gastric floating core-shell structured tablets with sustained-release [ 19 ], ophthalmologic patches with controlled drug release [ 20 ], cereal-based tablets for pediatric use [ 21 ], solid lipid tablets [ 22 ], chewable tablets [ 23 , 24 , 25 , 26 ], personalized orodispersible films [ 27 , 28 , 29 ], and suppositories [ 30 ].…”

“…Utilizing 3D printing to produce veterinary TPH products has, to the best of the authors’ knowledge, not previously been explored. However, SSE 3D printing has previously been investigated in the preparation of veterinary medicinal products containing prednisolone [ 28 ] and gabapentin (GBP) [ 26 ]. The current study aimed to examine if the same printing ink base used in the GBP study could be utilized with a different drug, namely TPH.…”