Semi‐Egg‐Like Heterogeneous Compartmentalization of Cells Controlled by Contact Angle Hysteresis

Sun, Kang; Liu, Mingjie; Liu, Hongliang; Zhang, Pengchao; Fan, Jun‐Bing; Meng, Jing; Wang, Shutao

doi:10.1002/adfm.201501527

Cited by 8 publications

(5 citation statements)

References 36 publications

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“…Spatial control of surface wettability (wetting contrast) plays an important role in several different applications, including thermal management systems, microfluidics, cell screening, microfabrication, and water collection . In all of these applications, wetting contrast allows for the controlled confinement and/or movement of water or aqueous solutions on a surface, to obtain for example cell confinement in microarrays or liquid transport in microfluidic devices.…”

mentioning

confidence: 99%

Water Collection by Sticky Microislands on Superomniphobic Electrospun Surfaces

Davis

Liakos

Genovese

et al. 2016

Adv Materials Inter

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and superoleophobic, SO) surfaces decorated with sticky islands, through the direct dispensing and curing of polydimethylsiloxane (PDMS) and toluene onto surfaces of fibrous perfluoralkyl methacrylic copolymer (PMC) and fumed silicon dioxide (SiO 2 ) nanoparticles. Due to the superomniphobicity of the fibrous surfaces, toluene/PDMS droplets could easily be placed on them using an ordinary syringe and needle assembly without wetting them. Moreover, because of the low adhesion between the droplets and the substrate, the contact line between the toluene/PDMS droplets and the SO fibers decreased as volume was withdrawn from the droplets, allowing for the deposition of sticky spots much smaller than would normally be possible with a dispensing syringe (millimeters), in the size range of spots created using more complex printing methods (100's of microns). Upon evaporation of the toluene and curing, well defined PDMS spots were found to adhere to the fibrous substrate. The water collecting ability of the developed surfaces composed of varying wetting patterns was then investigated when the surfaces were exposed to simulated fog. Unlike previous studies of water collection ability of patterned surfaces, an experimental setup was used that allowed not only for the recording of the total amount of water collected during the testing period, but also for the recording of the time and weight of each collection event. PDMS island size and separation both had a significant effect on the rate and initial time of fog collection, as well as on the mechanism of droplet accumulation and removal.Re-entrant texture such as the porosity found in fibrous surfaces has been found in previous works to be an important factor for creating superomniphobic surfaces. [38,39] Electrospinning is a preferred technology for the production of porous fiber networks that has in recent years become an industrialscale process. [40] Thus, for the development of the SO layers, PMC/SiO 2 nanofiber mats were prepared by electrospinning. The mats showed high contact angles, θ, for both water and oil (θ water = 160°, θ oil = 155°, Figure 1a). They also exhibited relatively low contact angle hysteresis, Δθ = θ adv -θ rec , where θ adv and θ rec are advancing and receding contact angles, respectively, and were thus self-cleaning (Δθ water = 21°, Δθ oil = 36°). However, fibers were observed to peel away with passing droplets as has been reported previously. [39,41] It was hypothesized that heating the electrospun mats would produce more stable surfaces through the fusing together of individual nanofibers. [42] Heat-treated substrates continued to show very high oil and water contact angles, independent of the heating temperature used, as shown in Figure 1a. On the other hand, after heating the nanofibers to 100 and 150 °C, Δθ water remained steady, while oil droplets were not able to roll off of the surface (i.e., "pinned" droplets). Heating to higher temperatures, however, Δθ began to Spatial control of surface wettability (wetting contrast) plays an important...

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mentioning

confidence: 99%

Water Collection by Sticky Microislands on Superomniphobic Electrospun Surfaces

Davis

Liakos

Genovese

et al. 2016

Adv Materials Inter

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“…[205][206][207][208][209] The idea is "to borrow Nature's design strategies to achieve novel functional materials, with highly useful properties exceeding by far those available by current methods," [210] but "not to copy Biology: learning in modesty from her principles and to transfer it to materials space and conditions previously not accessible to biology." [205][206][207][208][209] The idea is "to borrow Nature's design strategies to achieve novel functional materials, with highly useful properties exceeding by far those available by current methods," [210] but "not to copy Biology: learning in modesty from her principles and to transfer it to materials space and conditions previously not accessible to biology."…”

Section: Multicompartmentalizationmentioning

confidence: 99%

Design Principles and Multifunctionality in Cell Encapsulation Systems for Tissue Regeneration

Correia

Reis

Mano

2018

Adv Healthcare Materials

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Cell encapsulation systems are being increasingly applied as multifunctional strategies to regenerate tissues. Lessons afforded with encapsulation systems aiming to treat endocrine diseases seem to be highly valuable for the tissue engineering and regenerative medicine (TERM) systems of today, in which tissue regeneration and biomaterial integration are key components. Innumerous multifunctional systems for cell compartmentalization are being proposed to meet the specific needs required in the TERM field. Herein is reviewed the variable geometries proposed to produce cell encapsulation strategies toward tissue regeneration, including spherical and fiber-shaped systems, and other complex shapes and arrangements that better mimic the highly hierarchical organization of native tissues. The application of such principles in the TERM field brings new possibilities for the development of highly complex systems, which holds tremendous promise for tissue regeneration. The complex systems aim to recreate adequate environmental signals found in native tissue (in particular during the regenerative process) to control the cellular outcome, and conferring multifunctional properties, namely the incorporation of bioactive molecules and the ability to create smart and adaptative systems in response to different stimuli. The new multifunctional properties of such systems that are being employed to fulfill the requirements of the TERM field are also discussed.

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“…Therefore, there is a clear need for novel technologies capable of solving the problems of high experimental costs and embryo handling allowing for affordable in vivo screening of large compound libraries. Using novel synthetic materials, in particular patterned surfaces with different wettability, as platforms for biological applications was reported previously . In this study we developed a miniaturized system, droplet‐microarray (DMA) chip, for screening of zebrafish embryos based on the use of arrays of highly hydrophilic spots separated by superhydrophobic barriers.…”

Section: Introductionmentioning

confidence: 99%

Fish‐Microarray: A Miniaturized Platform for Single‐Embryo High‐Throughput Screenings

Popova

Marcato

Peravali

et al. 2017

Adv Funct Materials

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Small molecule high-throughput screenings are essential for the fields of drug discovery and toxicology. Such screenings performed on whole animals are more physiologically relevant leading to more predictive results. However, due to challenges in automation, high costs and absence of miniaturized solutions for animal-based experiments, high throughput screenings based on animal models are still in its infancy. Here a platform for miniaturized high throughput whole-organism screenings is presented. The new platform is based on patterns of hydrophilic spots separated by superhydrophobic borders. The difference in wettability of spots and borders generates the effect of discontinuous dewetting and allows for formation of arrays of microdroplets that incorporate single fish embryos. Due to the flat border-less nature of the platform, the system is compatible with single-step collection of embryos and pipetting-free parallel addition of chemical libraries using the "sandwiching method." The system is miniaturized and allows for incubation of embryos in volumes as low as 5 µL. Finally, the platform realizes surface tension based immobilization of single embryos inside of each microcompartment and permits high-throughput microscopic analysis directly on the platform. Thus, this method combines the advantages of microarrays, such as highthroughput and simplicity, with the power of in vivo experiments. Fish-Microarrays

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Semi‐Egg‐Like Heterogeneous Compartmentalization of Cells Controlled by Contact Angle Hysteresis

Cited by 8 publications

References 36 publications

Water Collection by Sticky Microislands on Superomniphobic Electrospun Surfaces

Water Collection by Sticky Microislands on Superomniphobic Electrospun Surfaces

Design Principles and Multifunctionality in Cell Encapsulation Systems for Tissue Regeneration

Fish‐Microarray: A Miniaturized Platform for Single‐Embryo High‐Throughput Screenings

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