Semi-automatic brain region extraction (SABRE) reveals superior cortical and deep gray matter atrophy in MS

Carone, Dominic A.; Benedict, Ralph H. B.; Dwyer, Michael G.; Cookfair, Diane L.; Srinivasaraghavan, Bhooma; Tjoa, Christopher W.; Zivadinov, Robert

doi:10.1016/j.neuroimage.2005.07.053

Cited by 64 publications

(67 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the deep gray matter, decreased NAA, 5 decreased volume, 6 and decreased attenuation of neuronal cells 3 have been reported in previous studies of MS, though there were fewer lesions present in these regions. The underlying pathophysiologic process of this rather typical neurodegeneration is still not well known.…”

Section: Discussionsupporting

confidence: 69%

“…1,2 Neurodegenerative changes have been identified in both histopathologic and advanced imaging studies in patients with MS, in which substantial neuronal loss is indicated by decreased neuronal attenuation, 3 N-acetylaspartate (NAA), 4,5 and volume in both cortical gray matter and deep gray matter nuclei, 6,7 which suggests a significant neuronal pathologic process in patients with MS. Deep gray matter structures such as the thalamus, putamen, globus pallidus, and caudate play significant roles in processing motor, sensory, cognitive, and emotional information.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Quantitative Assessment of Iron Accumulation in the Deep Gray Matter of Multiple Sclerosis by Magnetic Field Correlation Imaging

Jensen²,

Lu³

et al. 2007

American Journal of Neuroradiology

130

118

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 69%

mentioning

confidence: 99%

Quantitative Assessment of Iron Accumulation in the Deep Gray Matter of Multiple Sclerosis by Magnetic Field Correlation Imaging

Jensen²,

Lu³

et al. 2007

American Journal of Neuroradiology

130

118

View full text Add to dashboard Cite

show abstract

“…Evidence for brain atrophy is rarer in SLE, but when seen seems to be strongly correlated with cognitive impairment (Bosma et al 2002). In contrast, brain atrophy in MS can be severe (Benedict et al 2006b;Carone et al 2006;Ramasamy et al 2007), and when seen it often correlates with cortical and subcortical dementia (Benedict and Bobholz 2007).…”

Section: Discussionmentioning

confidence: 99%

Neuropsychological Impairment in Systemic Lupus Erythematosus: A Comparison with Multiple Sclerosis

et al. 2008

Self Cite

View full text Add to dashboard Cite

In this manuscript, we review literature describing the neuropsychological and brain imaging characteristics of systemic lupus erythematosus (SLE) patients. The findings are compared and contrasted with multiple sclerosis (MS) studies, revealing similarities and differences of interest to clinicians and researchers. While cognitive impairment is somewhat less common in SLE than MS, the diseases share a similar cognitive profile with deficits most prominent on tests emphasizing the speed of information processing, working memory, and visual/spatial learning, and memory. In early or more mildly affected patients, diffuse white matter damage, which may not be apparent on conventional brain imaging, plays a major role in clinical presentation and cognitive testing. The causes of white matter damage are very different, however, and in later stages of the disease MS and SLE appear to give rise to different forms of cerebral pathology. MS may be characterized by increasing brain atrophy affecting especially the cortical and deep gray matter, at least after conversion to secondary progressive course. There is less evidence for neurodegenerative changes in SLE, but patients are increasingly at risk for cerebrovascular disease. We conclude by offering some suggestions for future clinical and imaging research. KeywordsSystemic lupus erythematosus; Multiple sclerosis; Cognition; Memory; Processing speed; MRI; Effect size Systemic lupus erythematosus (SLE) is a relapsing-remitting autoimmune disease with wide ranging organ involvement and clinical symptoms varying from mild and transient symptoms to death. Cognitive impairment is reported in SLE, even among those patients without documented or overt signs of central nervous system (CNS) involvement. Presumably, cognitive disorder is the result of underlying brain disease although the precise mechanisms remain to be elucidated. The prevalence and degree of cognitive impairment is also uncertain.In this article we will endeavor to evaluate the evidence for neuropsychological impairment in SLE, and to compare the findings with that of MS, another immunological disorder whose symptoms wax and wane and which affects women more than men. Unlike SLE, MS is a disease that always impacts the CNS, and the causes of cognitive disorder in MS are better understood.

show abstract

“…Some studies have shown that WM atrophy is less prominent compared to GM atrophy due to more pronounced inlammatory processes that can mask atrophy [18,19]. It is believed that patients with MS regional atrophy may serve as a more sensitive marker of the severity of the disease than the general, but the results obtained in diferent studies are mixed and often directly contradict each other.…”

Section: Morphometry Of the Brain In Multiple Sclerosismentioning

confidence: 99%

MRI Morphometry of the Brain and Neurological Diseases

Котов¹

2017

New Insights Into Morphometry Studies

View full text Add to dashboard Cite

The diagnosis of diseases of the brain is based on additional methods, conirming the clinical diagnosis. One of the most objective methods is magnetic resonance imaging (MRI). A detailed quantitative evaluation became possible after the introduction of MRI voxel-morphometry-statistical analysis of structural MRI images using a computerized segmentation mater of the brain gray and white mater. The decrease in the volume of the brain, as a manifestation of cerebral atrophy, is a common feature of many neurological diseases. We performed a study of brain structures in multiple sclerosis, Parkinson's disease, and cerebrovascular diseases. In patients with multiple sclerosis the correlation was found between the score on a scale of Expanded Disability Status Scale and the total thickness of the cerebral cortex. In our study of the brain in Parkinson's disease, the amount of the substantia nigra was slightly lower than in the control. In patients with long-following Parkinson's disease, the volume of substantia nigra was signiicantly higher than in patients with early stage. The increased volume was determined by the accumulation of organic iron compounds as a sign of neurodegeneration.

show abstract

Semi-automatic brain region extraction (SABRE) reveals superior cortical and deep gray matter atrophy in MS

Cited by 64 publications

References 50 publications

Quantitative Assessment of Iron Accumulation in the Deep Gray Matter of Multiple Sclerosis by Magnetic Field Correlation Imaging

Quantitative Assessment of Iron Accumulation in the Deep Gray Matter of Multiple Sclerosis by Magnetic Field Correlation Imaging

Neuropsychological Impairment in Systemic Lupus Erythematosus: A Comparison with Multiple Sclerosis

MRI Morphometry of the Brain and Neurological Diseases

Contact Info

Product

Resources

About