Semi-automated determination of iodine in biological fluids by activation analysis

Heurtebise, M.

doi:10.1007/bf02513795

Cited by 18 publications

(10 citation statements)

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“…The iodine contents in iodine standard solution as KIO 3 and seawater spiked KIO 3 solution were determined by direct extraction after irradiation, and the results are the same as those in the same water but being treated with 0.5 mL of 0.3 mol/L KHSO 3 solution before extraction. UV irradiation was usually used for conversion of organic iodine in seawater to inorganic iodine. ,, It has also been reported that activation in the reactor (irradiation with a strong flux of thermal neutrons and γ-, β-, and X-rays) can rupture irreversibly any organically bound iodine in biological fluid and convert organic iodine to iodide. ,− Byrne et al found that the chemical yield of iodide in the serum spiked with thyroxine was the same as that in serum spiked with KI after irradiation at a neutron flux of 4 × 10 12 n cm -2 s -1 for 4 min. Smith et al also reported that the value of iodine determined as iodide in protein bound iodine after irradiation with reactor neutrons was the same as that determined by chemical ashing decomposition.…”

Section: Resultsmentioning

confidence: 99%

“…Separation of Different Chemical Species of Iodine. Ion exchange with strongly basic anion-exchange resin, such as Dowex-1, ,, Dowex-2, ,, and AG-1, ,, has been used to separate chlorine, bromine, and iodide from other ions and each other efficiently. The affinities of various anions for the resin of AG-1 are in the order 30 I - > phenolate > HSO 4 - > ClO 3 - > NO 3 - > Br - > CN - > HSO 3 - > NO 2 - > Cl - > HCO 3 - > IO 3 - > HCOO - > Ac - > OH - > F - .…”

Section: Resultsmentioning

confidence: 99%

“…In addition, it has been reported that organic iodine (e.g., thyroxine, protein bound iodine, etc.) was not adsorbed by an anion-exchanged column or can be easily eluted by deionized water. − Thus, this method can also be used to separate I - , IO 3 - , and organic iodine from each other.…”

Section: Resultsmentioning

confidence: 99%

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Determination of Chemical Species of Iodine in Seawater by Radiochemical Neutron Activation Analysis Combined with Ion-Exchange Preseparation

et al. 1999

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A method for the determination of iodide, iodate, organic iodine, and total iodine in seawater was developed. The behaviors of loading, washing, and eluting of iodide, iodate, and organic iodine in a strongly basic anion-exchange column (AG1-×4, chlorine form) were studied by 131I tracer. Iodide was separated from other iodine species and other ions by directly passing filtered natural seawater through an anion-exchange column, washing with deionized water and 0.5 mol/L KNO3 solution, and eluting with 2.0 mol/L KNO3. Organic iodine was separated by passing seawater through an ion-exchange column after iodate had been converted to iodide by KHSO3 and collecting effluent during loading and washing with deionized water. The iodine content was determined by neutron activation analysis with postirradiation separation using CCl4 extraction. Studies of the effect of chlorine, bromine, and iodine concentrations on the extraction separation show that the recovery of iodine decreases with increasing Br- and Cl- concentrations and decreasing I- concentration. Under the experimental conditions, iodine in seawater was quantitatively recovered, and a 0.2 μg/L detection limit for iodine was obtained. Concentrations of total iodine, I-, IO3 -, and organic iodine in seawater collected from Roskilde Fjord, Denmark, were determined.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Determination of Chemical Species of Iodine in Seawater by Radiochemical Neutron Activation Analysis Combined with Ion-Exchange Preseparation

et al. 1999

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“…When various aliquots (0.2 to 2 ml) of this urine specimen were taken for analysis, a linear relationship was achieved between the weight of iodine found and the volume of the sample. An estimation of the accuracy was made through comparative analyses of four urine samples by this method and by a semiautomated method of proved accuracy which involves the chromatography of Ion a Dowex 2-X8 column (8). In Table I is shown the comparison of the results.…”

Section: Resultsmentioning

confidence: 99%

Application of an iodide-specific resin to the determination of iodine in biological fluids by activation analysis

Heurtebise¹,

Ross²

1971

Anal. Chem.

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Foreign ions present (weight excess over P) 0.150 0.152 + 1.33 Ca(20), Fe(10), Cu(15) 0.300 0.295 -1.67 Al(30), Si(30) 0.300 0.296 -1.33 Zn(30), Pb(20) 0.400 0.420 +5.00 Asm(10), Cd(20) 0.250 0.260 +4.00 Se(20), Te(20) 0.200 0.200 0.0 Bi(15), Cu(20) 0.350 0.335 -4.30 W(20), Sb(25), Ge(25) 0.080 0.079 -0.62 Si(15), Ni(10) " Each result is the average of two determinations in good agreement.which the Rhodamine B recovered in the final butanolchloroform phase from the complex after its formation from known amounts of phosphorus was determined fluorimetrically. Allowance for depletion of the Rhodamine B concentration in the final chloroform-butanol phase due to the chloroform extractions, which promote the dissociation of the complex by removal of the excess reagent, was made. The overall cumulative formation constant, A, defined as [RhB-MPC]/[MPC][RhB]3, under these conditions was estimated to be 1.6 ± 0.3 X 1011 liter3 mole-3.Conclusions. High sensitivity is obtained for the determination of phosphorus by the spectrofluorimetric method developed. The sensitivity achieved is higher than that for most other methods based on the formation of molybdophosphoric acid, and compares favorably with that of more complex enzymatic methods. High selectivity is achieved with the optimum conditions established. Of the ions investigated, only arsenic(V) interferes seriously, by formation and extraction of the corresponding Rhodamine B molybdoarsenate; arsenic (III), however, may be tolerated when present in moderate excess with respect to phosphorus.

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“…Peisach, Comar, and Kellershohn (240) analyzed biological samples containing trace amounts of bromine by irradiation and measurement of the 11.9-keV K X-rays (emitted from 82mBr) by means of a Nal crystal covered with a beryllium window. Heurtebise (132) developed an automated system for the rapid determination of traces of iodine in biological fluids. The sample was irradiated, the I" separated from other anions by ion exchange, and then counted in an automated counting system in which the 128I was determined with a Nal(Tl) crystal connected to a multi-channel analyzer.…”

Section: Nonmetallic Elementsmentioning

confidence: 99%

Organic elemental analysis

S.¹,

Gutterson²

1974

Anal. Chem.

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This review follows the previous one (189) and covers the literature and information received by the authors from October 1971 to November 1973. As in the past, it surveys the developments in the determination of the elements in organic materials.Since the commercial CHN analyzers have been on the market for some ten years (186), time is come for an overall evaluation of these automated machines. At the International Symposium on Microtechniques held in University Park, Pa. in August 1973, several practicing microanalysts reported on the performance of the respective apparatus which they had used for long periods. The findings are favorable. At the same time, it is noted that the number of commercial instruments (187, 188) has diminished. Research activities on automation, however, have been vigorous, as evidenced by the papers on coulometric methods, use of ion-selective electrodes, and other elec-

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Semi-automated determination of iodine in biological fluids by activation analysis

Cited by 18 publications

References 1 publication

Determination of Chemical Species of Iodine in Seawater by Radiochemical Neutron Activation Analysis Combined with Ion-Exchange Preseparation

Determination of Chemical Species of Iodine in Seawater by Radiochemical Neutron Activation Analysis Combined with Ion-Exchange Preseparation

Application of an iodide-specific resin to the determination of iodine in biological fluids by activation analysis

Organic elemental analysis

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