This contribution presents a sliding-mode control approach for the mitigation of vibrations in frame-like structures. The control is implemented in a semi-active manner, that is, without significant external control forces and substantial power consumption, which are typical for active control approaches. Here, the control is achieved through dynamic, lowcost modification of properties at selected structural nodes. The employed actuators have the untypical form of two-state hinges, which can switch between two extreme states: no transfer of bending moments (effectively a hinge) and full transfer of bending moments (a locked hinge or a typical frame node). Consequently, the control forces are dissipative and coupled to the response. Previous research in this area focused on purely energetic considerations, aiming for global damping of vibrations. In contrast, this paper formulates the control objective in terms of local displacements of a selected degree of freedom, which can be interpreted as the task of isolating it from external excitations. This formulation is employed to define the target sliding hyperplane. The state of the actuators is chosen such that the effective control forces push the structural state toward the target hyperplane. The approach is verified in a numerical example of a six-story shear-type structure subjected to random seismic excitation.