Semen quality of young adult ICSI offspring: the first results

Belva, Florence; Bonduelle, M.; Roelants, Mathieu; Michielsen, D.; Steirteghem, André Van; Verheyen, Greta; Tournaye, Herman

doi:10.1093/humrep/dew245

Cited by 131 publications

(64 citation statements)

References 49 publications

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“…The first study on reproductive health in children conceived by ICSI showed that among 54 young adult men conceived by ICSI as a result of severe male infertility, the median sperm concentration, total sperm count, and total motile sperm count were significantly lower than in spontaneously conceived children, even after adjusting for relevant confounding factors. The men conceived by ICSI were almost three times more likely to have sperm concentrations of <15 million/ml, and were four times more likely to have a total sperm count of <39 million . Antral follicle count and reproductive hormones in a cohort of 71 young adult women conceived by ICSI because of male factor infertility were similar to those reported for women who were spontaneously conceived …”

Section: Key Pointssupporting

confidence: 54%

Short‐ and long‐term outcomes in children born after assisted reproductive technology

Pinborg

2018

BJOG

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It has been forty years since the first IVF child, Louise Brown, born in 1978 and now more than 7 million children are conceived after assisted reproductive technologies (ART). There has been a tremendous increase in the number of ART cycles and several more advanced treatments have been developed, such as intracytoplasmic sperm injection (ICSI). ICSI revolutionized the treatment of severe male factor infertility after the first ICSI baby born in 1992. This article is protected by copyright. All rights reserved.

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Section: Key Pointssupporting

confidence: 54%

Short‐ and long‐term outcomes in children born after assisted reproductive technology

Pinborg

2018

BJOG

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“…In order to offer sound advice to couples looking at ICSI, our findings should be considered along with those of others. In a recently published study, Belva et al (2016) foundafter correcting for several confounding factors -almost twice the sperm concentration in spontaneously conceived peers in comparison to ICSI men.…”

Section: Discussionmentioning

confidence: 97%

Are children born from singleton pregnancies conceived by ICSI at increased risk for congenital malformations when compared to children conceived naturally? A systematic review and meta-analysis

Lacamara¹,

Ortega²,

Villa³

et al. 2017

JBRA Assisted Reproduction

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Since 1992, the development of intra-cytoplasmic sperm injection (ICSI) has allowed infertile couples and couples affected by severe male factor infertility in particular, many of which with a history of failed traditional IVF, to become parents. This has generated considerable controversy over the safety of the procedure for the offspring. This systematic review seeks to determine whether evidence indicates that the use of ICSI increases the risk of congenital malformation in children born from singleton pregnancies versus naturally conceived children. Twenty-one of the 104 publications listed in the literature search were included in the analysis. Observational studies reported mostly an increased risk for congenital malformation; the risk of congenital malformations is 7.1% in ICSI and 4.0% in the general population (OR 1.99 (95% CI [1.87 -2.11]). However, attributing higher risk solely to ICSI might seem far-fetched, as in vitro and simulation procedures, patient diseases, and ICSI indication may also be associated with higher risk of malformation.

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“…Our knowledge of how environmental exposures affect epigenetic signatures and (reproductive) health of the offspring, however, is still in its infancy. Thirdly, the world's largest ICSI offspring cohort recently reached adulthood and has been reported to exhibit significantly decreased semen quality when compared with spontaneously conceived peers (Belva et al, 2016). These challenges show quite plainly that further studies are highly mandatory.…”

Section: Lesson: There Are Still More Questions Than Answers-good Timmentioning

confidence: 99%

Lessons learned in Andrology: Occupy a scientific niche, be proactive, and stay visible for the scientific community

Steger

2017

Andrology

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His research interests include the coordinated gene expression in haploid male germ cells, the identification of molecular biomarkers for sperm quality in order to predict the success of Assisted Reproductive Technology (ART) treatment, as well as sperm epigenetics and its possible impact on early embryo development. LESSON: DO NOT REPEAT MISTAKES THAT OTHERS ALREADY MADEPrevious authors contributing to this series already provided a plethora of valuable advice on how young scientists can boost their careers. Most of their thoughts were common and not specific for Andrology, such as never stop reading and writing. Although my thoughts are very similar, I will try to contribute some additional lessons. To be consistent with the style of this series, I will reflect on some milestones of my own career in order to provide any useful advice to those who are at the very beginnings of their careers. LESSON: AVOID DEAD ENDS IN YOUR CAREEROn reflection, my career was not fast-paced, but it was without any dead ends. Definitely, some of my decisions were rather because of good fortune than good judgment. That will apply for you, too. Whenever I could not decide on the better of two alternatives, I thought about which one I did not like and then chose the other option. Subsequently, I did not look back, but concentrated on the here and now and tried to pass as fast as possible in order to avoid wasting time. LESSON: IDENTIFY WITH YOUR PROJECT, DO NOT SOLELY WAIT FOR INSTRUCTIONS, TAKE THE INITIATIVEAt secondary school, biology was my favorite subject. In my last year, however, I had been told to become a computer specialist in order to acquire a job and earn money. While many of my classmates followed this advice, I did not. I could not imagine sitting in front of a computer for the rest of my life and,

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Semen quality of young adult ICSI offspring: the first results

Cited by 131 publications

References 49 publications

Short‐ and long‐term outcomes in children born after assisted reproductive technology

Short‐ and long‐term outcomes in children born after assisted reproductive technology

Are children born from singleton pregnancies conceived by ICSI at increased risk for congenital malformations when compared to children conceived naturally? A systematic review and meta-analysis

Lessons learned in Andrology: Occupy a scientific niche, be proactive, and stay visible for the scientific community

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