Semen quality of male smokers and nonsmokers in infertile couples

Künzle, Robert; Mueller, Michael D.; Hänggi, W.; Birkhäuser, Martin; Drescher, Heinz; Bersinger, Nick A.

doi:10.1016/s0015-0282(02)04664-2

Cited by 298 publications

(198 citation statements)

References 23 publications

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“…Earlier studies have concluded that toxins in cigarette smoke reach the male reproductive system and interact directly with components of the seminal fluid and the accessory endocrine system leading to increased viscosity, reduced seminal volume, and delayed liquefaction. This ultimately leads to the reduction of forward linear progression of spermatozoa, manifest as asthenozoospermia [Chia et al 1994;Kulikauskas et al 1985;Kunzle et al 2003;Zhang et al 2000]. However, in this population of infertile men, there is a trend towards increased oligozoospermic, teratozoospermic, and azoospermic phenotypes.…”

Section: Resultsmentioning

confidence: 99%

Effect of smoking on semen quality, FSH, testosterone level, and CAG repeat length in androgen receptor gene of infertile men in an Indian city

Mitra

Chakraborty

Mukhopadhay

et al. 2012

Systems Biology in Reproductive Medicine

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This study was conducted as part of an epidemiological survey of 126 nonsmokers and 178 smokers, showing primary infertility residing around Kolkata region of Eastern India. Their lifestyle history including smoking habits along with semen and blood were collected. The study examined the association of cigarette smoking with the risk of infertility, by determining the semen quality, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone levels, and androgen receptor (AR)-CAG repeat length in a group of smokers compared with a control group (non smokers). Based on conventional WHO criteria, lower sperm motility (P < 0.001) and increased sperm morphological defects (P < 0.0001) were associated with smoking habits. Binary logistic regression analysis for the effect of smoking status on sperm DNA integrity demonstrated significant positive correlation (p = 0.006). Serum FSH and LH levels were higher for smokers compared with non-smokers while the testosterone level decreased significantly with the increasing smoking habit. The mean length of CAG repeats in AR gene was significantly higher for smokers with low testosterone compared to non-smokers. The study suggested that smoking is associated with altered semen quality, endocrine hormonal status, and number of CAG repeats in the AR gene.

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Section: Resultsmentioning

confidence: 99%

Effect of smoking on semen quality, FSH, testosterone level, and CAG repeat length in androgen receptor gene of infertile men in an Indian city

Mitra

Chakraborty

Mukhopadhay

et al. 2012

Systems Biology in Reproductive Medicine

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“…Spermatozoa from subjects who smoked are signifi cantly more sensitive to acid-induced DNA denaturation than non-smokers (Potts et al, 1999). In a study of 655 smokers and 1131 non-smokers, it was shown that cigarette smoking was associated with a signifi cant decrease in sperm density, total sperm count, and total number of motile sperm (Kunzle et al, 2003). But, Tremellen et al, (2008) observed a signifi cant correlation between vitamin C intake and sperm concentration.…”

Section: Infertility Oxidative Stress and Vitamin Cmentioning

confidence: 99%

Vitamin C and oxidative stress in the seminiferous epithelium

et al. 2011

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In this article, we focus on the fundamental role of vitamin C transporters for the normal delivery of vitamin C to germ cells in the adluminal compartment of seminiferous tubules. We argue that the redox status within spermatozoa or in semen is partly responsible for the etiology of infertility. In this context, antioxidant defence plays a critical role in male fertility. Vitamin C, a micronutrient required for a wide variety of metabolic functions, has long been associated with male reproduction. Two systems for vitamin C transport have been described in mammals. Facilitative hexose transporters (GLUTs), with 14 known isoforms to date, GLUT1-GLUT14, transport the oxidized form of vitamin C (dehydroascorbic acid) into the cells. Sodium ascorbic acid co-transporters (SVCTs), SVCT1 and SVCT2 transport the reduced form of vitamin C (ascorbic acid). Sertoli cells control germ cell proliferation and differentiation through cell-cell communication and form the blood-testis barrier. Because the blood-testis barrier limits direct access of molecules from the plasma into the adluminal compartment of the seminiferous tubule, one important question is the method by which germ cells obtain vitamin C. Some interesting results have thrown light on this matter. Expression of SVCT2 and some isoforms of GLUT transporters in the testis have previously been described. Our group has demonstrated that Sertoli cells express functionally active vitamin C transporters. Kinetic characteristics were described for both transport systems (SVCT and GLUT systems). Sertoli cells are able to transport both forms of vitamin C. These fi ndings are extremely relevant, because Sertoli cells may control the amount of vitamin C in the adluminal compartment, as well as regulating the availability of this metabolite throughout spermatogenesis.

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“…The sperm quality that are tremendously affected include, sperm concentration (Martini et al, 2004;Condorelli et al, 2014), morphological abnormalities (Joo et al, 2012) and sperm motility (Gaur et al, 2010). These finding were reported contrarily across other studies where they find no association between alcohol consumption and sperm quality (Kunzle et al, 2003;Teijon et al, 2007;Li et al, 2009;Hansen et al, 2012;Povey et al, 2012;Jensen et al, 2014).…”

Section: Introductionmentioning

confidence: 84%

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

Jaafar¹,

Osman²,

Kumar³

et al. 2017

JAS

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There is no solid conclusion on the conventional sperm parameters in association with alcohol consumption, evaluation of sperm DNA integrity thus become a more reliable parameter. Hereby, this literature search was performed to summarize alcohol consumption on the sperm DNA integrity. A computerized database search was done through MEDLINE via Ovid (since 1946 until August 2017) and Cochrane was used. The following set of keywords: 'alcohol consumption OR alcohol intake OR alcohol diet OR drinking alcohol OR ethanol diet' AND 'sperm DNA OR sperm chromatin OR sperm genome OR sperm histone OR sperm protamine' were utilised. 24 articles were retrieved where only five studies conform to the inclusion criteria All studies demonstrated a negative effect of alcohol consumption on sperm DNA integrity, regardless of various range of alcohol doses and duration of alcohol consumption. Out of five studies reviewed, four studies were using a different approach to measure the sperm DNA damage. Hereby, this review identified a need to use a single approach of DNA damage test by having various method of alcohol administration and/or vice versa so that the extension of sperm DNA damage to alcohol consumption will have a better conclusion. On the same note, a few studies have reported the reversibility on conventional semen parameters, none has been done on the sperm DNA damage upon alcohol withdrawal. Therefore, the role of alcohol withdrawal on the reversibility of sperm DNA damage needs to be as well investigated further.

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Semen quality of male smokers and nonsmokers in infertile couples

Cited by 298 publications

References 23 publications

Effect of smoking on semen quality, FSH, testosterone level, and CAG repeat length in androgen receptor gene of infertile men in an Indian city

Effect of smoking on semen quality, FSH, testosterone level, and CAG repeat length in androgen receptor gene of infertile men in an Indian city

Vitamin C and oxidative stress in the seminiferous epithelium

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

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