Semen Parameters in Men with and Without Proven Chronic Prostatitis

Abstract

In patients with complaints of chronic prostatitis, analysis of prostatic secretions for leukocytes and the use of the four-specimen technique allow a distinct classification of chronic bacterial (CBP), nonbacterial prostatitis (NBP), and prostatodynia (Pd). In this study, 32 men with CBP, 102 men with NBP, 142 men with Pd, and 42 volunteers, classified as mentioned above, underwent a two-fold ejaculate analysis using WHO criteria. Sperm count, progressive motility, range of abnormal spermatozoa, increased numbers of common bacteria, and peroxidase-positive leukocytes were analyzed. Additionally, antibody-coated bacteria (ACB), numbers of ureaplasmas in semen, and urethral colonization by chlamydia were investigated. Mean values of sperm density, motility, and morphology revealed no differences between the groups. Significant bacteriospermia (greater than or equal to 10(3) bacterial/ml) was evident in only 47% of the CBP group versus 6.8% (NBP), 16% (Pd), and 4.2% (controls). ACB was positive in 31 of 32 men with CBP versus 3 of 102 with NBP, 9 of 142 with Pd, and none of the controls. Increased numbers of leukocytes were evident in CBP and NBP patients compared to the controls (p less than or equal to 0.001) but were also present in patients of the NBP and Pd groups with chlamydial infections.

Pathogenic Consequences in Semen Quality of an Autoimmune Response against the Prostate Gland: From Animal Models to Human Disease

“…The relationship between chronic prostatitis and infertility has been controversial for many years with some reports arguing for a positive relationship between chronic prostatitis and altered semen quality (9,10), whereas others showed no alterations (11,12). One possible explanation of such contradictory findings could be that CNBP comprises an heterogeneous group of patients and, as we and others have described (8,13,14), that the presence of autoimmune response against prostate Ags is detected only in a subset of patients with CNBP.…”

Interference of Human Spermatozoal Motility by Live Staphylococcus aureus

“…E. coli probably represents the most frequently isolated microorganism in genitourinary infections (Weidner et al, 1991). E. coli rapidly adheres to human spermatozoa in vitro, resulting in agglutination of spermatozoa (Diemer et al, 2003).…”

Infections génito-urinaires et infécondité masculine: conséquences, diagnostic et traitement

“…Seules deux etudes ont analyse les alterations des CBS dans le sperme de patients ayant une prostatite prouvee [93,51] : elles ont toutes deux mis en evidence un nombre plus eleve de leucocytes que chez les hommes sans inflammation (avec syndrome non inflammatoire douloureux pelvien chronique, N IH-IIIB). Finalement, une resolution evidente de la leucospermie survint awes traitement antibiotique [12].…”

“…Les effets nefastes de la prostatite chronique sur la numeration, la mobilite et la morphologie des spermatozo'ides sent I'objet de debat [93]. Toutes les investigations montrent ~ ce jour des resultats contradictoires et ne confirment pas un rele decisif de la prostatite chronique dans I'alteration de ces parametres (Tableau 7).…”

“…Le fructose a ete retrouve diminue chez les hommes presentant une prostatite chronique et chez les patients asymptomatiques avec leucocytospermie, mais ces resultats n'ont pas ete confirmes par d'autres auteurs [103]. Seules les etudes sur la forme destructive des prostatovesiculites ont montre une reduction significative de la quantite totale de fructose dans le sperme [90,93].…”