Semen parameters in men recovered from COVID-19

Guo, Tong; Sang, Min; Bai, Shun; Ma, Hui; Wan, Yangyang; Jiang, Xiaohua; Zhang, Yuan‐Wei; Xu, Bo; Chen, Hong; Zheng, Xueying; Luo, Sihui; Xie, Xuefeng; Gong, Chenjia; Weng, Jianping; Shi, Qinghua

doi:10.4103/aja.aja_31_21

Cited by 82 publications

(111 citation statements)

References 30 publications

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“…Characteristics of the 7 studies are described in Table 1. There were 5 12 13 21 22 , 1 10 , and 1 11 cross-sectional, case-control, and cohort studies, respectively. The participants either recovered from COVID-19 or were without a history of COVID-19 infection -and had a mean age and BMI of 37.34 ± 10.5 and 25.6 ± 0.65, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…These changes re ect the unfavorable effect of COVID-19 on the male reproductive system. A longitudinal study carried out among those recovered from COVID-19 observed a negative impact on sperm quality, although these were likely to be reversible 10 . However, Holtman et al found out that adverse effects on sperm count and sperm motility were only detected in hospitalized patients but not in subjects who have recovered after mild symptoms 11 .…”

Section: Introductionmentioning

confidence: 99%

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Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis

Tiwari¹,

Kc²,

Thapa

et al. 2021

Preprint

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Background: The novel beta-coronavirus disease (COVID-19) has infected millions of people globally with high risk among male then female. However, the effect of COVID-19 andrology is still a subject of dispute. We planned to analyze the overall consequences of COVID-19 on semen parameters and male sex hormones.Main text: Systematic search was performed on MEDLINE and Scopus database until June 11 2021. We included observational studies, which reported mean ± standard deviation of the semen parameters and serum sex hormones of those reproductive-aged male recovered from COVID-19 and controls who did not suffered from COVID-19. We used Random-effect model to pool the studies, as heterogeneity was present. Heterogeneity was evaluated by Q test and I2. All studies were assessed with their quality and publication bias.We assessed 966 articles for eligibility and found 7 eligible studies meeting PICO criteria. This include 934 participants with mean age 37.34 ± 10.5. Random-effect model meta-analysis showed that men recovered form COVID-19 had semen parameters less than those who had not suffered from COVID-19. The overall mean difference (MD) [95% confidence interval (CI)] in semen volume, sperm concentration, sperm number, and progressive sperm motility was -0.20 (-0.45, 0.05), -16.59 (-34.82, 1.65), -45.44 (-84.56, -6.31), -1.73(-8.20, 4.75) respectively. Considering sex hormones; Luteinizing hormone and prolactin was found more among those recovered with the significant MD (95% CI) of 3.47 (1.59, 5.35) and 3.21 (1.71, 4.72) respectively.Conclusion: Both the semen parameters and sexual hormones were found to be affected after infected with COVID-19. However, the mechanism for testicular involvement remains doubtful.This systematic review and meta-analysis has been registered in PROSPERO (ID: CRD42021259445)

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis

Tiwari¹,

Kc²,

Thapa

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Furthermore, analyses of changes in semen parameters among serial semen samples showed improvements with increasing length of recovery from COVID-19. 15 , 48 These results suggest that the effect of COVID-19 on semen parameters is linked to disease severity; these changes appear to be reversible after recovery from COVID-19.…”

Section: Discussionmentioning

confidence: 84%

“…Previous studies concerning specific semen quality parameters have yielded conflicting results. Some studies showed decreases in sperm count, 15 , 46 – 49 percentage of total motility, 48 – 50 and percentage of cells with normal morphology 46 in semen samples from patients who had recovered from COVID-19. Other studies have shown no changes in the percentages of total motility 46 or cells with normal morphology.…”

Section: Discussionmentioning

confidence: 99%

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Effects of the COVID-19 pandemic on semen quality in male partners of infertile couples: a hospital-based observational study

Kumar

Jha

Zabihullah

et al. 2022

Asian Journal of Andrology

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The effects of the coronavirus disease 2019 (COVID-19) pandemic on male fertility have received considerable attention because human testes contain high levels of angiotensin-converting enzyme-2 receptors, through which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can enter. Early studies showed decreases in semen quality during and after recovery from COVID-19. However, no semen quality studies have examined the effects of widespread subclinical and mild disease, as well as changes in lifestyle, psychosocial behavior, intake of dietary supplements, and stress. This cross-sectional study compared semen quality parameters in male partners of infertile couples between men who underwent semen analysis before the COVID-19 pandemic (prepandemic group) and men who underwent semen analysis during the pandemic period (pandemic group); the analysis sought to clarify the overall effects of the pandemic. No participants in the pandemic group had experienced clinically overt disease. Among the 239 participants, mean body weight ( P = 0.001), mean body mass index ( P < 0.001), median sperm concentration ( P = 0.014), total sperm count ( P = 0.006), and total percentages of motile ( P = 0.013) and abnormal cells ( P < 0.001) were significantly greater in the pandemic group ( n = 137) than those in the prepandemic group ( n = 102). Among abnormal cells, the percentages of cells with excess residual cytoplasm ( P < 0.001), head defects ( P < 0.001), and tail defects ( P = 0.015) were significantly greater in the pandemic group than those in the prepandemic group. With the exception of morphology, the overall semenogram results were better in the pandemic group than those in the prepandemic group.

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Semen parameters after SARS‐CoV‐2 infection: A literature review

Tufvesson

Catalini

Fedder

2022

Health Science Reports

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Background and Aims The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is known to affect multiple organs by binding to angiotensin‐converting enzyme 2 receptors and might therefore affect male fertility. This review aims to collect all original articles on the effects of SARS‐CoV‐2 infection on male fertility, including the duration of time after infection required for these effects to begin to manifest and recommend how clinicians should approach cases with a recent illness. Methods This review was developed according to the preferred reporting items for systematic reviews and meta‐analyses guidelines. The search string was applied to four online databases—namely Pubmed, Embase, Medline, and the Cochrane COVID‐19 Register—and screened using the online tool Covidence.org . Articles were eligible for inclusion if they were cohort studies involving a healthy male population diagnosed with COVID‐19, each of whom had semen samples collected before and after the infection or two different semen samples collected after the diagnosis. Results Nine cohort studies were eventually included. Five articles had pre‐ and post‐COVID‐19 data while four had two sets of post‐COVID‐19 data. The three largest studies found a statistically significant decrease in all semen parameters when waiting less than 3 months from diagnosis before sample collection, and no significant differences in results when the ejaculate was analyzed more than 3 months after recovery. One study compared the COVID‐19 patients with a control group and found a significant decrease in semen parameters in the COVID‐19 group. Conclusion Spermatogenesis seems to be affected by SARS‐CoV‐2 infection, but the impact tends to reverse within 3–4 months. It is still unclear why male fertility is affected by SARS‐CoV‐2 infection, and it might be the result of several different components. Clinicians should consider recent SARS‐CoV‐2 infection as a possible reason for the low semen quality of patients' semen samples, and might therefore need to collect new samples after 4 months before further treatment.

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Semen parameters in men recovered from COVID-19

Cited by 82 publications

References 30 publications

Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis

Semen parameters in men recovered from COVID-19: a systematic review and meta-analysis

Effects of the COVID-19 pandemic on semen quality in male partners of infertile couples: a hospital-based observational study

Semen parameters after SARS‐CoV‐2 infection: A literature review

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