Semen parameters and hormonal profile in obese fertile and infertile males

Hofny, Eman R. M.; Ali, Marfoua S.; Abdel-Hafez, Hisham Zayan; Kamal, Emad Eldien; Mohamed, Essam Eldien; El-Azeem, Hanan G. Abd; Mostafa, Taymour

doi:10.1016/j.fertnstert.2009.03.085

Cited by 186 publications

(122 citation statements)

References 39 publications

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“…On the contrary, in a meta-analysis conducted by Sermondade et al, a negative relationship between BMI and semen parameters was detected (7). There are also original studies reporting similar results (15)(16)(17). While a statistically significant negative relationship was detected between BMI and semen volume, concentration and motility in a comprehensive cohort study including 10665 patients conducted by Belloc et al, no relationship with morphology was detected (18).…”

Section: Discussionmentioning

confidence: 79%

Investigation of the effect of body mass index (BMI) on semen parameters and male reproductive system hormones

Keskın

Budak

Aksoy

et al. 2017

Arch Ital Urol Androl

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Aim: To evaluate the effects of body mass index (BMI) ratio on semen parameters and serum reproductive hormones. Materials and methods: The data of 454 patients who prsented to male infertility clinics in our hospital between 2014 and 2015 were analyzed retrospectively. Weight, height, serum hormone levels and semen analysis results of the patients were obtained. BMI values were calculated by using the weight and height values of the patients and they were classified as group 1 for BMI values ≤ 25 kg/m 2 , as group 2 for BMI values 25-30 kg/m 2 and as group 3 for BMI values ≥ 30 kg/m 2 . Results: The mean values of BMI, semen volume, concentration, total motility, progressive motility, total progressive motile sperm count (TPMSC), normal morphology according to Kruger, head abnormality, neck abnormality, tail abnormality, FSH, LH, prolactin, T/E2, total testosterone and estradiol parameters of the patients were considered. Patients were divided according to BMI values in Group 1 (n = 165), Group 2 (n = 222) and Group 3 (n = 56). There was no statistically significant difference in terms of all variables between the groups. Conclusions: We analyzed the relationship between BMI level and semen parameters and reproductive hormones, demonstrating no relationship between BMI and semen parameters. In our study, BMI does not affect semen parameters although it shows negative correlation with prolactin and testosterone levels.KEY WORDS: Infertility; BMI; Semen parameters; Reproductive hormones. number of studies and in some studies this decrease was found as associated to the increase in obesity prevalence (2). But, there is not a consensus in the literature and contradictory results were published. In this study, we analyzed the effect of BMI on semen parameters and the relationship with reproductive hormone levels. MATERIALS AND METHODSThe data of 454 patients who presented to male infertility clinics in our hospital between 2014 and 2015 were analyzed retrospectively. Weight, height, serum hormone levels and semen analysis results of the patients were considered. BMI values were calculated by using the weight and height values of the patients and they were classified as Group 1 for BMI values ≤ 25 kg/m 2 , as Group 2 for BMI values 25-30 kg/m 2 and as Group 3 for BMI values ≥ 30 kg/m 2 . Semen analysis was performed after a 3-5 days of sexual abstinence. Semen analysis was performed according to WHO 2010 criteria (semen volume ≥ 1.5 ml; sperm concentration ≥ 15 × 106/ml; total motility ≥ 40%, progressive motility ≥ 32% and morphology ≥ 4%). After 5-30 minutes of sample collection, the analysis was performed after the sample was liquefied. For the microscopic examination in semen analysis, phase contrast light microscope was used and the examination was performed with 10 x 20 magnification. For sperm concentration, Makler counting chamber was used and the sperm count (concentration) was found in million/ml with the sperm count in 10 squares in a 100 square area. Motility was evaluated in 3 Groups as linear progressive...

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Section: Discussionmentioning

confidence: 79%

Investigation of the effect of body mass index (BMI) on semen parameters and male reproductive system hormones

Keskın

Budak

Aksoy

et al. 2017

Arch Ital Urol Androl

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show abstract

“…A study of over 500 infertile couples from Utah has shown that large body mass tripled the relative risk of oligospermia and reduced total motile count in men with BMI over 30 kg/m 2 [13]. Similar associations were reported in healthy young Danish men reporting for a pre-army physical [14] and Egyptian infertility patients [15]. In further support of these observations, increased DNA fragmentation has been demonstrated in sperm from obese men [16][17][18].…”

Section: Introductionmentioning

confidence: 67%

Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles

Keltz

Zapantis

Jindal

et al. 2010

J Assist Reprod Genet

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Purpose To evaluate if elevated male body mass influences success after assisted reproductive technologies Methods Retrospective study of 290 cycles. Results Male body mass index greater than 25.0 kg/m 2 was associated with significantly lower clinical pregnancy (53.2% vs. 33.6%). Multivariable logistic regression indicated that the likelihood of clinical pregnancy was decreased if the male partner was overweight after in vitro fertilization but not after intracytoplasmic sperm injection (odds ratios: 0.21 [0.07-0.69] vs. 0.75 [0.38-1.49], respectively) after adjustment for number of embryos transferred, sperm concentration, female age and body mass. Conclusion In this cohort, overweight status of the male partner was independently associated with decreased likelihood of clinical pregnancy after in vitro fertilization but not after intracytoplasmic sperm injection. A detrimental impact of higher male body mass was observed after adjusting for sperm concentration, suggesting that intracytoplasmic sperm injection may overcome some obesity related impairment of sperm-egg interaction.

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“…concentration, motility and sperm morphology [27][28][29]. Finding a negative effect on these parameters, i.e.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between the Amount of Subcutaneous Fat, Testicular Morphometry, Epididymis and Some Sperm Parameters in Leptonycteris yerbabuenae Bat Before, During and After Mating

Martínez–Coronel¹,

Alicia²,

Arenas‐Ríos³

2015

AVS

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Studies in reproductive age mammals show that the increase in fat content is inversely related to sperm quality in response to a decrease in testosterone levels. In turn the decrease in androgen concentration is related to morphophysiological involution in the testis and epididymis. However, the bat Leptonycteris yerbabuenae increases the body fat content previous the mating period, contrary to what was reported in most mammals. Therefore the aim of this study was to determine the importance of variation in fat content in L. yerbabuenae in relation to testicular and epididymal cycle; and sperm parameters. The results clearly show an increase in the fat content as it approaches the mating season. Also, there is an increase in the size of the testis and epididymis. In the post-mating months, both: fat and testis, decrease and the sperm cells were not presents. Leptonycteris yerbabuenae has a different behaviour to most mammals, accumulate fat while producing, transit and sperm storage could be happening. So, in this model, we must do studies that meet these processes emerging from that reported in other mammals.

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Semen parameters and hormonal profile in obese fertile and infertile males

Cited by 186 publications

References 39 publications

Investigation of the effect of body mass index (BMI) on semen parameters and male reproductive system hormones

Investigation of the effect of body mass index (BMI) on semen parameters and male reproductive system hormones

Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles

Relationship Between the Amount of Subcutaneous Fat, Testicular Morphometry, Epididymis and Some Sperm Parameters in Leptonycteris yerbabuenae Bat Before, During and After Mating

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