Semen Astragali Complanati: An ethnopharmacological, phytochemical and pharmacological review

Ng, Yam-Fung; Tang, Philip Chiu‐Tsun; Sham, Tung-Ting; Lam, W F; Mok, Daniel K. W.; Chan, Shun‐Wan

doi:10.1016/j.jep.2014.06.013

Cited by 22 publications

(16 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a review of recent studies on the effects of Semen of Phyllolobium chinense Fisch. (SPC) on metabolic parameters associated with NAFLD, Ng et al found that active contents of SPC including fatty acids, amino acids, polysaccharides, flavonoids, and triterpene glycosides had antihypertensive, antidiabetic, anticancer, antioxidant, and antifibrotic effects and that administration of crude extract of SPC as well as administration of total flavonoids and triterpene glycosides in SPC had lipid-lowering and liver protection effects in rats that had been fed a high lipid diet [73]. …”

Section: Recent Studies Of Tcm For Treatment Of Nafldmentioning

confidence: 99%

A Review of Western and Traditional Chinese Medical Approaches to Managing Nonalcoholic Fatty Liver Disease

Hsu

Sheen

Lin

et al. 2016

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is a disease of attention because of increase in prevalence from 20% to 41%. The clinical and pathological conditions in patients with NAFLD range from steatosis alone to nonalcoholic steatohepatitis (NASH) with or without fibrosis to hepatic cancer. In the United States, NAFLD was the second-leading indication for liver transplant between 2004 and 2013. Although imaging studies such as magnetic resonance elastography and the use of diagnostic panels and scoring systems can provide a fairly accurate diagnosis of NAFLD, there are few treatment options for patients with mild to moderate disease other than lifestyle modification. Many of the currently used medical treatments have been shown to cause severe side effects and some have been shown to be associated with increased risk for certain types of cancer. In recent years, a number of traditional Chinese herbal treatments have been examined for their potential uses as treatment for NAFLD. In this review, we provide a general overview of NAFLD and a survey of Western pharmacologic drugs currently used to treat the disease as well as the results of recent studies on the effectiveness of traditional Chinese herbal remedies for managing nonalcoholic fatty liver disease.

show abstract

Section: Recent Studies Of Tcm For Treatment Of Nafldmentioning

confidence: 99%

A Review of Western and Traditional Chinese Medical Approaches to Managing Nonalcoholic Fatty Liver Disease

Hsu

Sheen

Lin

et al. 2016

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 98%

“…A previous study showed its pharmacological effects lie in the seed extracts of A. complanatus (Ng et al 2014). However, this extract includes many compounds such as fatty acids, amino acids, polysaccharides, flavonoids, triterpene glycosides, and trace element (Ng et al 2014). Recently, the major bioactive element of SAC, flavonoids from A. complanatus (FAC), was identified by highperformance liquid chromatography (HPLC) (Qi et al 2011) Flavonoids are a composite of 11 chemical compounds, which exist extensively in a lot of plates.…”

Section: Introductionmentioning

confidence: 98%

Effects and mechanism of flavonoids from Astragalus complanatus on breast cancer growth

Zhang

Zhu

Zhang

et al. 2015

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Flavonoids from Astragalus complanatus R.Br (FAC) had anticancer effects on many tumor cells. The current study was performed to evaluate the effects of FAC on human breast cell proliferation, apoptosis, and metastasis, as well as their active mechanism. Cell viability and growth were detected using the cell counting kit (CCK)-8 assay in vitro. Assay of FAC on induced breast cancer mortality was counted as survival time of nude mice after breast cell line inoculation. The effect of FAC on cell invasion was investigated by an optimization assay that contains a 96-well Boyden chamber with wells precoated with BME at three different concentrations. The mechanism of its action on apoptosis and metastasis was determined by related gene detection. Proliferation of three breast cell lines was inhibited with FAC treatment in a dose-dependent manner. Survival time of nude mice with breast cancer cell inoculation also was prolonged with increasing FAC dose. Metastasis in FAC-treated breast cells was also significantly inhibited. Real-time polymerase chain reaction (PCR) assay demonstrated that apoptosis-related BCL-2 and caspase-9 gene expression was consistent with their phenotype change. Metastasis-related FAK and BRCA1 gene expression was inversely related to FAC treatment. Western blot analysis indicated that BCL-2 and FAK proteins were reduced, whereas caspase-9 and BRCA1 proteins were increased with a higher dose of FAC treatment. These data suggested that FAC has an important role in breast cancer growth and metastasis suppression in vitro and in vivo. Its active mechanism involves promoting programmed cancer cell death and regulates metastasis-related gene expression.

show abstract

“…Br., has long been considered a health-keeping foodstuff in Chinese culture and was officially indexed in the Pharmacopoeia of the People's Republic of China (Pharmacopoeia Commission of the PRC, 2010) due to its health-promoting and medical functions, such as antioxidant (Zhang, Fan, Zhang, Wang, & Wang, 2012), antifatigue, antidiabetic (Deng, Yao, Xie, Zhang, & Zhuang, 2013), antiviral (Qi, Liu, Wu, Gu, & Guo, 2011), arresting seminal discharge, protecting kidney, antifibrosis in liver (Liu, Gu, Zhou, & Guo, 2005), antihypertensive (Xue, Li, Chai, Liu, & Chen, 2008), lipidregulating and anti-aging (Ng et al, 2014). Regarding these health effects, the compounds that are considered contributors include flavonoids (Zhang et al, 2013a(Zhang et al, , 2010, organic acids, amino acids, triterpenoids (Cui, Sakai, Takeshita, Kinjo, & Nohara, 1992), myricomplanoside complanatoside A, neocomplanoside and complanatoside B (Zhang et al, 2013b).…”

Section: Introductionmentioning

confidence: 99%

Physicochemical properties and in-vitro antioxidant capacity of Semen Astragali Complanati wine

Fan

Zhang

Yan

et al. 2016

CyTA - Journal of Food

View full text Add to dashboard Cite

In this paper, the physicochemical properties of the Semen Astragali Complanati wine was first investigated including the pH, electrical conductivity (EC), titratable acid, alcohol content, residual sugars, chromatic characteristics and flavonoids, and thereafter the in-vitro antioxidant capacity and its correlation with the total phenolic and flavonoids content were systematically evaluated and analyzed for the different fractions of the Semen Astragali Complanati wine by six antioxidant assays and the Pearson product-moment correlation, respectively. On a whole, there are no significant differences between the Semen Astragali Complanati wine and the grape wine regarding most of the conventional enological parameters. The antioxidant assays showed that the Semen Astragali Complanati wine exerts great antioxidant capacity, which is attributed to the high content of polyphenols and flavonoids contained such as complanatoside A and rhamnocitrin, since high correlations exhibited between the total content of phenols and flavonoids, and the in-vitro antioxidant activity, respectively. All these results indicate that the Semen Astragali Complanati could be fermented to wine and be as a natural source of antioxidants preventing damage associated with free radicals and offer alternatives to develop high value-added products to enhance health benefits.Las propiedades fisicoquímicas y la capacidad antioxidante in vitro del vino de Semen Astragali Complanati RESUMEN En este estudio se han investigado las propiedades fisicoquímicas del vino de Semen Astragali Complanati incluyendo el pH, la conductividad eléctrica, la acidez valorable, el contenido de alcohol, los residuos de azúcares, las características cromáticas y los flavonoides, después se evaluó sistemáticamente la capacidad antioxidante in vitro y su correlación con el contenido total de fenoles y flavonoides. Además se analizaron diferentes fracciones de vino de Semen Astragali Complanati mediante seis ensayos antioxidantes y la correlación producto-momento de Pearson, respectivamente. En conjunto, no se encontraron diferencias significativas entre el vino de Semen Astragali Complanati y el vino de uva en lo que concierne a los principales parámetros enológicos. Los ensayos antioxidantes mostraron que el vino de Semen Astragali Complanati ejerce una gran capacidad antioxidante, la cual se atribuye al alto contenido de polifenoles y flavonoides que contienen complanatoside A y ramnocitrina, debido a las altas correlaciones exhibidas entre el contenido total de fenoles y flavonoides, además de la actividad antioxidante in vitro, respectivamente. Todos estos resultados indican que Semen Astragali complanati podría ser fermentado a vino y ser una fuente natural de antioxidantes que previene los daños asociados con los radicales libres, además de ofrecer alternativas al desarrollo de productos con un alto valor añadido para favorecer beneficios para la salud. ARTICLE HISTORY

show abstract

Semen Astragali Complanati: An ethnopharmacological, phytochemical and pharmacological review

Cited by 22 publications

References 11 publications

A Review of Western and Traditional Chinese Medical Approaches to Managing Nonalcoholic Fatty Liver Disease

A Review of Western and Traditional Chinese Medical Approaches to Managing Nonalcoholic Fatty Liver Disease

Effects and mechanism of flavonoids from Astragalus complanatus on breast cancer growth

Physicochemical properties and in-vitro antioxidant capacity of Semen Astragali Complanati wine

Contact Info

Product

Resources

About