Semantische Demenz: Klinisches Profil und kognitiv-neuropsychologische Bedeutung

Eisfeld, I. S.

doi:10.1055/s-2004-818393

Cited by 5 publications

(4 citation statements)

References 46 publications

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“…However, if semantic studies have often been carried out, there are, to our knowledge, only a few on texts [25] [31] [32], other than those made to validate the Barbizet test used for this paper [33] [34]. The inability for a patient to express his or her own suffering [35] faced by a world that escapes his or her consciousness is a source of suffering both for the patient and his family [36] [37] [38]. Understanding language mechanisms is thus contingent to understanding the meaning of symptoms expressed by the patient's behaviour [22] [37] [39].…”

Section: Introductionmentioning

confidence: 99%

Narrativity and Memory Analysis in Alzheimer’s Disease

Hazif‐Thomas¹,

Billon²,

Thomas³

2017

OJPsych

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Alzheimer's Disease (AD) is a neurodegenerative illness with frequency of occurrence increasing with old age. If memory impairment setting progressively is here an element associated upfront, other neurocognitive troubles are also associated, for example, language impairment which can degenerate into aphasia. Aim of the study. To evaluate semantic and textual impairment in AD. Methods. Populations studied concerned 151 AD patients in consultation at Brest University Hospital. Certain sociodemographic data (sex, age, cultural levels) were collected as well as results from neuropsychological tests: (Folstein-MMSE; Dubois's 5-word test; fluencies, Dubois' s frontal test battery; Cornell's scale for depression; Barbizet's test, "The Lion's tale", for textual analysis. Demented patients were composed of 102 females and 49 males of average age 80.3 ± 6.91. All the tests, including the number of items memorized latterly in the Barbizet's test are impaired all the more by Folstein's test being altered. The formal fluency on demented patients is less impaired than the semantic lexical fluency test (scored respectively 5.74 ± 1. 09 versus 4.41 ± 2. 19; t = 5.60, p < 0.01). The studied demented cohort shows more intrusions (n = 36) than inversions in the delayed Lion's tale, whether for items or for episodes in which they occur (n = 19). The regressive PLS analysis shows that for the explanation of the overall scores to do with "The lion's tale", calculated later, only attainment of formal fluency has any notable influence (Regression coefficient CR = 0.224) or, more accessorily, the cultural level (CR = 0.12). Conclusions: Attainment of category fluency and patient culture levels has effects on narrativity.

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Section: Introductionmentioning

confidence: 99%

Narrativity and Memory Analysis in Alzheimer’s Disease

Hazif‐Thomas¹,

Billon²,

Thomas³

2017

OJPsych

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“…1 Diagnosekriterien der SD gemäß den revidierten Konsensuskriterien [4] (modifiziert nach[53]) AD). Die Profile wurden auf Basis der in der Tabelle aufgeführten Quellenangaben erstellt.…”

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Semantische Demenz

Henry

Merten

2008

Fortschr Neurol Psychiatr

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Semantic dementia (SD) is a relatively rare primary degenerative brain disease, often with onset before the age of 65, which belongs to the group of frontotemporal lobar degenerations. The central characteristic of SD is a progressive loss of semantic knowledge with manifestation in aphasia as well as impaired face and object recognition. A reliable discrimination of SD from other neurodegenerative conditions, in particular from Alzheimer's disease, may be a challenge for neurologists as well as neuropsychologists. In the first place, a sound knowledge base is expected from the expert in order to minimize false diagnoses. To illustrate this, a detailed case history of a 55-year old patient is presented who was referred for an independent medical and neuropsychological examination for disability benefits. The referral question was Pick's disease. However, the clinical manifestation as well as the results of a comprehensive neuropsychological evaluation clearly indicated the diagnosis of SD with neuroimaging and neuropsychological evidence of marked right temporal lobe atrophy. The case history highlights a number of problems inherent in current practice of dementia assessment. For differential diagnosis of dementing conditions, a thorough neuropsychological assessment appears to be indispensable.

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“…Bei der SD kommt es zu ei− nem Verlust des Wissens um die Bedeutung von Wörtern, Ge− genständen, Gesichtern etc. Dementsprechend wird bei weiter− hin flüssiger Sprache der Wortschatz der betroffenen Patienten kleiner, es kommt zu Verständnisschwierigkeiten und Wortfin− dungsstörungen [3,6]. Manchmal schon zu Beginn der Erkran− kung, spätestens aber im Verlauf, treten auch Verhaltensverän− derungen wie bei der FTD auf [4,7,8].…”

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Frühsymptome, Überlebenszeit und Todesursachen - Beobachtungen an 115 Patienten mit Demenz auf der Grundlage frontotemporaler lobärer Degenerationen

Diehl‐Schmid

Pohl

Perneczky

et al. 2007

Fortschr Neurol Psychiatr

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The early and differential diagnosis of the clinical phenotypes of frontotemporal lobar degeneration (FTLD), including frontotemporal dementia (FTD), semantic dementia (SD) and non-fluent progressive aphasia (NFPA), can be challenging. It may be difficult not only to differentiate these conditions from normal aging, psychiatric disorders, and other dementias, but also to distinguish between them. For early diagnosis, information on the initial and presenting symptoms of the FTLD phenotypes is essential. In the present study caregivers of 78 patients with FTD, 20 patients with SD and 17 patients with PA were interviewed about initial symptoms. In patients with FTD, the most frequent initial symptoms were alterations of personality, followed by forgetfulness and word finding difficulty. Patients with SD presented with word finding difficulty and behavioral disturbances. Almost all patients with PA developed word finding difficulty as the first manifestation of their disorder. Diagnostic latency - the time from disease onset to diagnosis was 4.1 years in FTD, 4.2 years in SD and 3.1 years in PA. Caregivers, and in some cases also patients, should be educated about the likely course and mortality of FTLD. To obtain information about survival time and cause of death associated with FTLD we analyzed follow-up data on 106 patients of whom 25 had died. The median survival time from the occurrence of first symptoms was 14 years. Mortality risk was significantly higher in patients with an early disease onset. Causes of death were varied, but pneumonia and sudden unexplained deaths were particularly frequent.

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Semantische Demenz: Klinisches Profil und kognitiv-neuropsychologische Bedeutung

Cited by 5 publications

References 46 publications

Narrativity and Memory Analysis in Alzheimer’s Disease

Narrativity and Memory Analysis in Alzheimer’s Disease

Semantische Demenz

Frühsymptome, Überlebenszeit und Todesursachen - Beobachtungen an 115 Patienten mit Demenz auf der Grundlage frontotemporaler lobärer Degenerationen

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