Addressing the requirements of academic end users, the Grid paradigm and its underlying technologies was in past developed and evolved neglecting the needs of potential business end users. Nowadays the trend changed towards the use of Grid technologies within electronic business (e-Business) which at the same time requires adapting existing technologies to allow for more flexible, intelligent and reliable support for business stakeholders. The BREIN project was the first one integrating two so far parallel evolving domains into the Grid, namely multi-agent and semantics. By this, the Grid was enhanced to provide the requested capabilities from business end users. This chapter will show the rationale behind the performed developments and the way how BREIN addresses its four main objectives of enabling and/or enhancing: (i) Autonomy and Automation, (ii) Self-Optimization, (iii) Context-Aware Security, (iv) Reduced Complexity of Use with a dedicated focus on the major pillars of the framework, Virtual Organizations (VOs) and Service Level Agreements (SLAs). With that, a generic solution is presented, which can be applied to a variety of distinct application areas.