Semantic Processing

Binder, Jeffrey R.; Fernandino, Leonardo

doi:10.1016/b978-0-12-397025-1.00266-9

Cited by 24 publications

(12 citation statements)

References 148 publications

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“…2014 ). Indeed, some regions engaged by the auditory localizer may be involved in abstract conceptual processing, rather than sound perception (e.g., bilateral dmPFC; Binder and Desai 2011 ; Binder and Fernandino 2015 ). However, our main conclusions regarding left AAC and thalamus are not compromised by this issue.…”

Section: Discussionmentioning

confidence: 99%

Task-Dependent Functional and Effective Connectivity during Conceptual Processing

2021

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Conceptual knowledge is central to cognition. Previous neuroimaging research indicates that conceptual processing involves both modality-specific perceptual-motor areas and multimodal convergence zones. For example, our previous functional magnetic resonance imaging (fMRI) study revealed that both modality-specific and multimodal regions respond to sound and action features of concepts in a task-dependent fashion (Kuhnke P, Kiefer M, Hartwigsen G. 2020b. Task-dependent recruitment of modality-specific and multimodal regions during conceptual processing. Cereb Cortex. 30:3938–3959.). However, it remains unknown whether and how modality-specific and multimodal areas interact during conceptual tasks. Here, we asked 1) whether multimodal and modality-specific areas are functionally coupled during conceptual processing, 2) whether their coupling depends on the task, 3) whether information flows top-down, bottom-up or both, and 4) whether their coupling is behaviorally relevant. We combined psychophysiological interaction analyses with dynamic causal modeling on the fMRI data of our previous study. We found that functional coupling between multimodal and modality-specific areas strongly depended on the task, involved both top-down and bottom-up information flow, and predicted conceptually guided behavior. Notably, we also found coupling between different modality-specific areas and between different multimodal areas. These results suggest that functional coupling in the conceptual system is extensive, reciprocal, task-dependent, and behaviorally relevant. We propose a new model of the conceptual system that incorporates task-dependent functional interactions between modality-specific and multimodal areas.

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Section: Discussionmentioning

confidence: 99%

Task-Dependent Functional and Effective Connectivity during Conceptual Processing

2021

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“…It has been proposed that the AG acts as a cross-modal convergence zone that integrates semantic features related to various sensory-motor modalities (Binder 2016;Fernandino et al 2016;Kuhnke et al 2020b). This theory is corroborated by the AG's proximity to and connectivity with several sensory-motor cortices (Bonner et al 2013;Binder and Fernandino 2015;Kuhnke et al 2021).…”

Section: Introductionmentioning

confidence: 72%

“…The view that the AG is a domain-general region showing task-difficulty-related deactivation (Lambon Ralph et al 2016;Humphreys et al 2021) would predict that the AG is consistently deactivated during both semantic and non-semantic conditions, and that the level of AG activity can be explained by task difficulty alone. In contrast, the view that the AG is engaged in semantic processing (Seghier 2013;Binder and Fernandino 2015;Kuhnke et al 2020b) would predict that AG responses cannot be explained by task difficulty alone, but it is crucial to consider semantic processing demand. Regarding laterality, we hypothesized that left AG might show stronger semantic effects than right AG, given that left AG showed more consistent engagement in meta-analyses of semantic processing (Binder et al 2009;Jackson 2021).…”

Section: Introductionmentioning

confidence: 99%

The Role of the Angular Gyrus in Semantic Cognition – A Synthesis of Five Functional Neuroimaging Studies

Kuhnke

Chapman

Cheung

et al. 2021

Preprint

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Semantic knowledge is central to human cognition. The angular gyrus (AG) is widely considered a key brain region for semantic cognition. However, the role of the AG in semantic processing is controversial. Key controversies concern response polarity (activation vs. deactivation) and its relation to task difficulty, lateralization (left vs. right AG), and functional-anatomical subdivision (PGa vs. PGp subregions). Here, we combined the fMRI data of five studies on semantic processing (n = 172) and analyzed the response profiles from the same anatomical regions-of-interest for left and right PGa and PGp. We found that the AG was consistently deactivated during non-semantic conditions, whereas response polarity during semantic conditions was inconsistent. However, the AG consistently showed relative response differences between semantic and non-semantic conditions, and between different semantic conditions. A combined analysis across all studies revealed that AG responses could be best explained by independent effects of both task difficulty and semantic processing demand. Task difficulty effects were stronger in PGa than PGp, regardless of hemisphere. Semantic effects were stronger in left than right AG, regardless of subregion. These results suggest that the AG is independently engaged in both domain-general task-difficulty-related processes and domain-specific semantic processes. In semantic processing, we propose that left AG acts as a “multimodal convergence zone” that binds different semantic features associated with the same concept, enabling efficient access to task-relevant features.

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“…A common view holds that the AG acts as a cross-modal convergence zone or “hub” that binds and integrates semantic features related to various sensory-motor modalities (Damasio 1989; Mesulam 1998; Binder and Desai 2011; Seghier 2013). This view is supported by the AG’s location at the junction between several sensory-motor processing streams (e.g., somatomotor, auditory, visual; Seghier 2013; Binder and Fernandino 2015; Margulies et al 2016). Moreover, the AG shows extensive structural (Hagmann et al 2008; Bonner and Price 2013) and functional (Tomasi and Volkow 2011; Kuhnke et al 2021) connectivity with various sensory-motor cortices.…”

Section: Discussionmentioning

confidence: 96%

The role of the angular gyrus in semantic cognition – A synthesis of five functional neuroimaging studies

Kuhnke

Chapman

Cheung

et al. 2021

Preprint

View full text Add to dashboard Cite

Semantic knowledge is central to human cognition. The angular gyrus (AG) is widely considered a key brain region for semantic cognition. However, the role of the AG in semantic processing is controversial. Key controversies concern response polarity (activation vs. deactivation) and its relation to task difficulty, lateralization (left vs. right AG), and functional-anatomical subdivision (PGa vs. PGp subregions). Here, we combined the fMRI data of five studies on semantic processing (n = 172) and analyzed the response profiles from the same anatomical regions-of-interest for left and right PGa and PGp. We found that the AG was consistently deactivated during non-semantic conditions, whereas response polarity during semantic conditions was inconsistent. However, the AG consistently showed relative response differences between semantic and non-semantic conditions, and between different semantic conditions. A combined analysis across all studies revealed that AG responses could be best explained by independent effects of both task difficulty and semantic processing demand. Task difficulty effects were stronger in PGa than PGp, regardless of hemisphere. Semantic effects were stronger in left than right AG, regardless of subregion. These results suggest that the AG is independently engaged in both domain-general task-difficulty-related processes and domain-specific semantic processes. In semantic processing, we propose that left AG acts as a "multimodal convergence zone" that binds different semantic features associated with the same concept, enabling efficient access to task-relevant features.

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Semantic Processing

Cited by 24 publications

References 148 publications

Task-Dependent Functional and Effective Connectivity during Conceptual Processing

Task-Dependent Functional and Effective Connectivity during Conceptual Processing

The Role of the Angular Gyrus in Semantic Cognition – A Synthesis of Five Functional Neuroimaging Studies

The role of the angular gyrus in semantic cognition – A synthesis of five functional neuroimaging studies

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