Semantic knowledge of newly coined words in mild cognitive impairment and Alzheimer’s disease

Borg, Céline; Bedoin, Nathalie; Basaglia-Pappas, Sandrine; Laroche, L; Minvielle, B.; Chesnoy, Gabrielle; Thomas‐Antérion, Catherine

doi:10.1016/j.jneuroling.2012.02.002

Cited by 5 publications

(5 citation statements)

References 54 publications

(65 reference statements)

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“…Testing non-verbal semantics might be informative, to detect whether those subtle semantic deficits span both verbal and non-verbal domains. Verbal memory for newly learned words has also been shown to be impaired in MCI [33, 34]. …”

Section: Introductionmentioning

confidence: 99%

Language in Amnestic Mild Cognitive Impairment and Dementia of Alzheimer’s Type: Quantitatively or Qualitatively Different?

Jokel¹,

Lima²,

Fernandez³

et al. 2019

Dement Geriatr Cogn Disord Extra

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Background/Aims: The purpose of this study was to explore language differences between individuals diagnosed with amnestic mild cognitive impairment multiple domain (aMCIm) and those with probable Alzheimer’s disease, with a goal of (i) characterizing the language profile of aMCIm and (ii) determining whether the profiles of dementia of Alzheimer’s type (DAT) and aMCIm individuals are on a continuum of one diagnostic entity or represent two distinct cognitive disorders. Methods: Language data from 28 patients with consensus diagnosis of aMCIm and DAT derived from a retrospective chart review were compared to that of healthy controls. Results: A non-parametric statistic established that there was no significant difference between groups in age, years of education or duration of symptoms and that expressive language was found to be relatively intact in both patient groups. In contrast, both groups exhibited significant impairments on receptive language tests and on linguistically complex tasks that rely on episodic memory and executive functions. Individuals with aMCIm and DAT present with configurations of language features that are largely in parallel to each other and reflect predominantly quantitative differences. Conclusion: Language tests provide an important contribution to the diagnostic process in their capacity to identify language impairments at an early stage. Understanding the nature of language decline is critically important to the intervention process as this information would inform cognitive intervention approaches aimed at promoting quality of life in people living with MCI and dementia.

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Section: Introductionmentioning

confidence: 99%

Language in Amnestic Mild Cognitive Impairment and Dementia of Alzheimer’s Type: Quantitatively or Qualitatively Different?

Jokel¹,

Lima²,

Fernandez³

et al. 2019

Dement Geriatr Cogn Disord Extra

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“…Although response inhibition in the real world is often based on how objects we encounter are categorized (e.g., when walking through the woods, deciding whether to take a step or not when a rope versus a snake is encountered), to our knowledge, none have studied the Go/NoGo paradigm in aMCI in the context of semantic categorization. Given that semantic memory deficits have been observed in behavioral [69][70][71][72][73][74] and ERP [75,76] studies in aMCI, examining response execution and inhibition in the context of semantic categorization could provide useful information as to whether these operations interact in individuals with aMCI.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Amnestic Mild Cognitive Impairment on Go/NoGo Semantic Categorization Task Performance and Event-Related Potentials

Mudar

Chiang²,

Eroh³

et al. 2016

JAD

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We examined the effects of amnestic mild cognitive impairment (aMCI) on behavioral (response times and error rates) and scalp-recorded event-related potential (ERP) measures of response execution and inhibition, using Go/NoGo tasks involving basic and superordinate semantic categorization. Twenty-five aMCI (16 F; 68.5±8 years) and 25 age- and gender-matched normal control subjects (16 F; 65.4±7.1 years) completed two visual Go/NoGo tasks. In the single car task, responses were made based on single exemplars of a car (Go) and a dog (NoGo) (basic). In the object animal task, responses were based on multiple exemplars of objects (Go) and animals (NoGo) (superordinate). The aMCI subjects had higher commission errors on the NoGo trials compared to the control subjects, whereas both groups had comparable omission errors and reaction times during the Go trials. The aMCI subjects had significantly prolonged N2 ERP latency during Go and NoGo trials across tasks compared to the controls. Both groups showed similar categorization effects and response type effects in N2/P3 ERP latencies and P3 amplitude. Our findings indicate that altered early neural processing indexed by N2 latency distinguishes subjects with aMCI from controls during the Go/NoGo task. Prolonged Go-N2 latency in aMCI appears to precede behavioral changes in response execution, whereas prolonged NoGo-N2 latency underlies behavioral deterioration in response inhibition.

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“…The scoring procedure used was the same as that used by Borg et al (2012). In this test, each word was scored on 3 points, using three tasks.…”

Section: Nwq Scoring Schemementioning

confidence: 99%

The relationship between semantic and episodic memory: evidence from a case of severe anterograde amnesia

Polin,

Lacroix,

Boutet

et al. 2023

Cognitive Neuropsychology

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Semantic knowledge of newly coined words in mild cognitive impairment and Alzheimer’s disease

Cited by 5 publications

References 54 publications

Language in Amnestic Mild Cognitive Impairment and Dementia of Alzheimer’s Type: Quantitatively or Qualitatively Different?

Language in Amnestic Mild Cognitive Impairment and Dementia of Alzheimer’s Type: Quantitatively or Qualitatively Different?

The Effects of Amnestic Mild Cognitive Impairment on Go/NoGo Semantic Categorization Task Performance and Event-Related Potentials

The relationship between semantic and episodic memory: evidence from a case of severe anterograde amnesia

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