Semantic hyperpriming in thought-disordered patients with schizophrenia: state or trait?—a longitudinal investigation

Gouzoulis-Mayfrank, Euphrosyne; Voss, Tatjana; Mörth, Dina; Thelen, B.; Spitzer, Manfred; Meincke, Ulrich

doi:10.1016/s0920-9964(03)00066-5

Cited by 60 publications

(32 citation statements)

References 35 publications

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“…Semantic relatedness disturbances that could contribute to the failure to recognize or make use of semantic associations in schizophrenia have been reported previously in priming studies [74][75][76] (see Minzenberg et al 39 for a review), studies looking at clustering of responses along common dimensions during semantic fluency tasks, 77,78 and studies in which subjects are asked to make judg- (REPRINTED) ARCH GEN PSYCHIATRY/ VOL 64 (NO. 9), SEP 2007ments of proximity, congruency, or relatedness between concepts.…”

Section: Abnormal Semantic Relatedness Processingmentioning

confidence: 79%

Selective Abnormal Modulation of Hippocampal Activity During Memory Formation in First-Episode Psychosis

Achim

Bertrand²,

Sutton³

et al. 2007

Arch Gen Psychiatry

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Context: Memory is one of the cognitive functions most affected in schizophrenia, with deficits observed from the first episode of psychosis (FEP). Previous studies have indicated that some memory processes may be more affected than others.Objective: To examine the neural correlates of 3 specific memory processes in FEP by means of functional magnetic resonance imaging (fMRI).Design: Case-control study. Main Outcome Measures:Behavioral performance and regional brain activity measured during memory encoding by fMRI. Our fMRI design included 3 within-subject contrasts (associative vs item-oriented encoding, encoding of arbitrary vs semantically related image pairs, and successful vs unsuccessful memory encoding) that were then used for group conjunctions and between-group analyses.Results: Patients with FEP showed normal activation of several brain regions, including the prefrontal cortex, hippocampus, and parahippocampal cortex, during successful memory encoding and associative encoding. In contrast, the hippocampus and surrounding medial temporal areas showed reduced activity during the encoding of arbitrary pairs. This selective dysfunction reflected by abnormal brain activation during encoding was accompanied by a greater deficit for subsequent recognition of arbitrary pairs relative to the semantically related pairs.Conclusions: This study demonstrated that, in the same group of patients with FEP, the hippocampus could show either normal or abnormal modulation of activation depending on the specific cognitive process that was examined. The normal modulation of hippocampal activation observed during successful memory encoding in FEP argues against a general inability to recruit this region. Instead, the dysfunction was specifically linked to semantic relatedness. This selective deficit seems to affect memory performance in FEP and denotes an important representational problem that may confer greater vulnerability to psychotic disorders and would thus be interesting to examine in high-risk populations. Psychiatry. 2007;64(9):999-1014 Arch Gen

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Section: Abnormal Semantic Relatedness Processingmentioning

confidence: 79%

Selective Abnormal Modulation of Hippocampal Activity During Memory Formation in First-Episode Psychosis

Achim

Bertrand²,

Sutton³

et al. 2007

Arch Gen Psychiatry

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show abstract

“…These studies provide rather convincing evidence that indeed, late processes of context use are abnormal (e.g., Adams et al, 1993;Nestor et al, 1997;Niznikiewicz et al, 1997;Koyama et al, 1991;Grillon et al, 1991;Hokama et al, 2003;Salisbury et al, 2002;Sitnikova et al, 2002;Ruchsow et al, 2003;Iakimova et al, 2005;Kostova et al, 2003;Kiang et al, 2008). Additional variables that may influence the results are the length of illness (Maher et al, 1996) and the degree of thought disorder (Aloia et al, 1998;Gouzoulis-Mayfrank et al, 2003). The association between N400 amplitude and severity of thought disorder was also reported (Kostova et al, 2005).…”

Section: Introductionmentioning

confidence: 80%

Abnormal inhibitory processes in semantic networks in schizophrenia

Niznikiewicz

Mittal

Nestor

et al. 2010

International Journal of Psychophysiology

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“…More particularly, thought disorders have been posited to stem from dysfunctional spreading of automatic activation within the semantic network (Spitzer, 1997). Numerous studies have reported an association between thought disorders and enhanced semantic priming, which reflects abnormally fast or far-reaching spreading of activation among the related concepts (Gouzoulis-Mayfrank et al, 2003;Moritz et al, 2003;Quelen et al, 2005;Kreher et al, 2008Kreher et al, , 2009Pomarol-Clotet et al, 2008;Kiefer et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Abnormal functioning of the semantic network in schizophrenia patients with thought disorganization. An exemplar production task

Brébion

Stephan‐Otto

Huerta‐Ramos

et al. 2013

Psychiatry Research

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Semantic hyperpriming in thought-disordered patients with schizophrenia: state or trait?—a longitudinal investigation

Cited by 60 publications

References 35 publications

Selective Abnormal Modulation of Hippocampal Activity During Memory Formation in First-Episode Psychosis

Selective Abnormal Modulation of Hippocampal Activity During Memory Formation in First-Episode Psychosis

Abnormal inhibitory processes in semantic networks in schizophrenia

Abnormal functioning of the semantic network in schizophrenia patients with thought disorganization. An exemplar production task

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