Semaforin Sema4D in the Immune System in Multiple Sclerosis

Куклина, Е. М.; Байдина, Т В; Danchenko, I. Yu.; Nekrasova, I. V.

doi:10.1007/s10517-014-2533-x

Cited by 15 publications

(7 citation statements)

References 14 publications

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“…Investigation of the expression of CD100 on lymphocytes revealed disease associated increase in CD100 on T lymphocytes and shedding from the membrane of activated T cells in multiple sclerosis (MS). MS was also associated with a decrease of CD72 receptor expression by B lymphocytes suggesting a possible contribution of CD100 to the disease development via the direct effects in the CNS and the immunomodulatory effect on B cell activity regulation (Kuklina et al 2014). Modulation of B cell regulatory molecules CD22 and CD72 in myasthenia gravis (MG) and MS has been reported by Lu et al (2013).…”

Section: Functional Effects and Disease Associations Of Human Cd72mentioning

confidence: 87%

Calcyclin

2018

Encyclopedia of Signaling Molecules

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Section: Functional Effects and Disease Associations Of Human Cd72mentioning

confidence: 87%

Calcyclin

2018

Encyclopedia of Signaling Molecules

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“…In patients with Systemic Lupus Erythematosus, low expression of CD72 on B cells is negatively correlated with patient disease activity (SLEDAI) ( 28 ). CD72 is lowly expressed in multiple sclerosis and its ligand CD100 is increased in T cells ( 29 ). CD72 is lowly expressed in NPC tissues, suggesting that our low CD72 expression may be related to poor prognosis in NPC patients.…”

Section: Discussionmentioning

confidence: 99%

Construction of lncRNA and mRNA co-expression network associated with nasopharyngeal carcinoma progression

Chen

Wang

et al. 2022

Front. Oncol.

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Nasopharyngeal carcinoma is a type of head and neck cancer with a high incidence in men. In the past decades, the survival rate of NPC has remained around 70%, but it often leads to treatment failure due to its distant metastasis or recurrence. The lncRNA-mRNA regulatory network has not been fully elucidated. We downloaded the NPC-related gene expression datasets GSE53819 and GSE12452 from the Gene Expression Omnibus database; GSE53819 included 18 NPC tissues and 18 normal tissues, and GSE12452 included 31 NPC tissues and 10 normal tissues. Weighted gene co-expression network analysis was performed on mRNA and lncRNA to screen out modules that were highly correlated with tumor progression. The two datasets were subjected to differential analysis after removing batch effects, and then Venn diagrams were used to screen for overlapping genes in the module genes and differential genes. The lncRNA-mRNA co-expression network was then constructed, and key mRNAs were identified by MCODE analysis and expression analysis. GSEA analysis and qRT-PCR were performed on key mRNAs. Through a series of analyses, we speculated that BTK, CD72, PTPN6, and VAV1 may be independent predictors of the prognosis of NPC patients.Taken together, our study provides potential candidate biomarkers for NPC diagnosis, prognosis, or precise treatment.

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“…The involvement of B lymphocytes has been increasingly recognized in the occurrence of primary Sjogren's Syndrome (pSS) [6]. And CD72, being a coreceptor of B cell receptor (BCR), has been reported to be an important regulator in the pathogenesis of several autoimmune diseases [20][21][22][23]25]. However, the role of CD72 in pSS has been rarely studied [24].…”

Section: Discussionmentioning

confidence: 99%

“…In SLE patients, the lower expression of CD72 on B cells was inversely associated with patients' disease activity (SLEDAI) and correlated with the presence of lupus nephritis, anti-dsDNA antibodies and low levels of complement [20]. In multiple sclerosis, the expression of CD72 decreased along with an increase in expression of its ligand CD100 on T cells and abnormal levels of several inflammatory factors [22,23]. Conversely, CD72 expression was upregulated on CD19 + CD27+ memory B cells in immune thrombocytopenia (ITP), and was associated with platelet count and anti-platelet antibodies [25].…”

Section: Discussionmentioning

confidence: 99%

“…The expression of CD72 on B cells decreased while the serum soluble CD72(sCD72) level increased in SLE patients as compared to health controls [20,21]. Moreover, the expression of CD72 on B cells also decreased in patients with multiple sclerosis [22,23]. In contrast, the expression of CD72 on B cells was upregulated in pSS patient in the study by Smith et al [24].…”

Section: Introductionmentioning

confidence: 96%

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A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren’s syndrome

Shi

Xie

et al. 2020

BMC Immunol

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Background: CD72, a co-receptor of B cell receptor (BCR), has been reported to have both positive and negative effects on B cell functions in several immunological diseases. The B cell plays an important role in the pathogenesis of primary Sjogren's syndrome (pSS). However, whether CD72 is involved in the process remains unknown. This study aimed to observe the possible role of CD72 in the pathogenesis of pSS. Results: A total of 60 cases who fulfilled the American-European Consensus Group (AECG) criteria for the diagnosis of pSS and 61 gender and age-matched healthy controls were recruited in this study. The percentage of CD72+ B cells was 85.31 ± 8.37% in pSS patients and 76.91 ± 8.50% in healthy controls(p < 0.001). The percentage of CD72+ B cells was correlated to serum IgG levels in patients [β = 0.018(0.001-0.036), p = 0.034]. The level of serum soluble CD72 was significantly higher in pSS patients than the one in healthy controls (0.41 (0.29) vs 0.07 (0.08) ng/mL, p < 0.001). Conclusions: The percentage of CD72+ B cells was upregulated in pSS patients and was correlated to the serum IgG level, which revealed the hyperactivity of B cells in this disease. The serum soluble CD72 level was also increased in pSS patients. These results indicated a potential role of CD72 in the pathogenesis of pSS.

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Semaforin Sema4D in the Immune System in Multiple Sclerosis

Cited by 15 publications

References 14 publications

Calcyclin

Calcyclin

Construction of lncRNA and mRNA co-expression network associated with nasopharyngeal carcinoma progression

A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren’s syndrome

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