“…Mesotherapy is a minimally invasive technique consisting of multiple epi‐ or intradermal injections of nutrients, hormones, vitamins, enzymes and other reagents. The aim of mesotherapy in skin rejuvenation is maintenance or restoration of healthy and youthful texture of skin (1–9). However, optimal protocols to achieve this goal, that is the quality of medication formulas and the mode of their application as well as the proof of concept, including long‐term efficiency, are still lacking (10–12).…”