Selol, an organic selenium donor, prevents lipopolysaccharide-induced oxidative stress and inflammatory reaction in the rat brain

Dominiak, Agnieszka; Wilkaniec, Anna; Jęśko, Henryk; Czapski, Grzegorz A.; Lenkiewicz, Anna; Kurek, Eliza; Wroczyński, Piotr; Adamczyk, Agata

doi:10.1016/j.neuint.2017.02.014

Cited by 28 publications

(13 citation statements)

References 102 publications

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“…Measurement of the ROS level was carried out using fluorescent probe 2 ,7 -dichlorodihydrofluorescein diacetate (DCFH-DA), as described previously [117]. DCFH-DA is deacetylated by cellular esterases to 2 ,7 -dichlorodihydrofluorescein (DCFH) and then may be oxidized to a highly fluorescent compound, 2 ,7 -dichlorofluorescein (DCF).…”

Section: Measurement Of the Reactive Oxygen Species (Ros) Levelmentioning

confidence: 99%

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Maternal Immune Activation Induces Neuroinflammation and Cortical Synaptic Deficits in the Adolescent Rat Offspring

Cieślik

Gąssowska-Dobrowolska

Jęśko

et al. 2020

IJMS

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Maternal immune activation (MIA), induced by infection during pregnancy, is an important risk factor for neuro-developmental disorders, such as autism. Abnormal maternal cytokine signaling may affect fetal brain development and contribute to neurobiological and behavioral changes in the offspring. Here, we examined the effect of lipopolysaccharide-induced MIA on neuro-inflammatory changes, as well as synaptic morphology and key synaptic protein level in cerebral cortex of adolescent male rat offspring. Adolescent MIA offspring showed elevated blood cytokine levels, microglial activation, increased pro-inflammatory cytokines expression and increased oxidative stress in the cerebral cortex. Moreover, pathological changes in synaptic ultrastructure of MIA offspring was detected, along with presynaptic protein deficits and down-regulation of postsynaptic scaffolding proteins. Consequently, ability to unveil MIA-induced long-term alterations in synapses structure and protein level may have consequences on postnatal behavioral changes, associated with, and predisposed to, the development of neuropsychiatric disorders.

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Section: Measurement Of the Reactive Oxygen Species (Ros) Levelmentioning

confidence: 99%

“…The levels of oxidized (GSSG) and reduced forms of glutathione (GSH) as well as total GSH content were measured according to Dominiak et al [117] using an enzymatic assay kit (Item No. 703002, Cayman Chemical, Ann Arbor, MI, USA).…”

Section: Determination Of Glutathione Levelsmentioning

confidence: 99%

Maternal Immune Activation Induces Neuroinflammation and Cortical Synaptic Deficits in the Adolescent Rat Offspring

Cieślik

Gąssowska-Dobrowolska

Jęśko

et al. 2020

IJMS

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“…Investigations about Selol mostly concern its anticancer activities [17,18,19,20,21,23,29], very little work has been done on antioxidant activities and potential use for not cancerous cells. The present study demonstrated the high level of selenium assimilation from this mixture of selenized-lipids and confirmed the lower toxicity in comparison to other selenocompounds.…”

Section: Discussionmentioning

confidence: 99%

“…The search for bioavailable selenocompounds with lower toxicity than selenite drove research to design a selenized triglyceride, which is produced by the reaction of selenite with sunflower oil. This compound referred to as Selol is currently investigated for its potential anticancer properties and antineoplastic effects [17,18,19,20,21]. The reaction of sunflower oil with selenite generates a complex mixture of selenitriglycerides, which has been characterized recently by high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP MS) and high performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC ESI MS/MS).…”

Section: Introductionmentioning

confidence: 99%

Selenized Plant Oil Is an Efficient Source of Selenium for Selenoprotein Biosynthesis in Human Cell Lines

et al. 2019

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Selenium is an essential trace element which is incorporated in the form of a rare amino acid, the selenocysteine, into an important group of proteins, the selenoproteins. Among the twenty-five selenoprotein genes identified to date, several have important cellular functions in antioxidant defense, cell signaling and redox homeostasis. Many selenoproteins are regulated by the availability of selenium which mostly occurs in the form of water-soluble molecules, either organic (selenomethionine, selenocysteine, and selenoproteins) or inorganic (selenate or selenite). Recently, a mixture of selenitriglycerides, obtained by the reaction of selenite with sunflower oil at high temperature, referred to as Selol, was proposed as a novel non-toxic, highly bioavailable and active antioxidant and antineoplastic agent. Free selenite is not present in the final product since the two phases (water soluble and oil) are separated and the residual water-soluble selenite discarded. Here we compare the assimilation of selenium as Selol, selenite and selenate by various cancerous (LNCaP) or immortalized (HEK293 and PNT1A) cell lines. An approach combining analytical chemistry, molecular biology and biochemistry demonstrated that selenium from Selol was efficiently incorporated in selenoproteins in human cell lines, and thus produced the first ever evidence of the bioavailability of selenium from selenized lipids.

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“…Selenium protects cellular elements from oxidative damage and may participate in redox-type reactions. Low plasma selenium concentrations are associated with subtle neurological impairments reflected in soft neurological signs [84,85]. Plasma Se was the only statistically significant difference of up to 16 elements identified for PD patients [86] relative to Alzheimer's disease patients.…”

Section: Parkinson's Diseasementioning

confidence: 93%

Reactive Oxygen Species and Selenium in Epilepsy and in Other Neurological Disorders

Antila¹,

Westermarck²,

Latvus³

et al. 2020

Personalized Medicine, in Relation to Redox State, Diet and Lifestyle

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Oxidative stress has been implicated in epilepsy and various neurodegenerative disorders. In this review, we elaborate oxidative stress-mediated neuronal loss and assess the role of selenium in some neurological disorders including epilepsy. Selenium as an essential trace element has attracted the attention of many researchers because of its potentialities in human health. It has an important role in the brain, immune response, defense against tissue damage, and thyroid function. Selenium forms part of the active site of the peroxide-destroying enzyme glutathione peroxidase (GSHPx), and it also has other functions, for example in biotransformation and detoxification. Functional and clinical consequences of selenium deficiency states in neurological diseases have been described, and the selenium requirement, which is influenced by various processes, has been discussed. Wide variations have been found in selenium status in different parts of the world, and populations or groups of patients exposed to marginal deficiency are more numerous than was previously thought. Chronic diseases, such as neurological disorders, heart disease, diabetes, cancer, aging, and others, are reported to associate with markers of oxidative damage. It is, therefore, not unreasonable to suggest that antioxidants would alleviate the oxidative damage, resulting in health improvements. In recent years, accumulated evidence in nutrigenomics, laboratory experiments, clinical trials, and epidemiological data have established the role of selenium in a number of conditions. Most of these effects are related to the function of selenium in the antioxidant enzyme systems. Current research activities in the field of human medicine and nutrition are devoted to the possibilities of using selenium as an adjuvant for the treatment of degenerative or free radical diseases such as neurological disorders, inflammatory diseases, and cancer.

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Selol, an organic selenium donor, prevents lipopolysaccharide-induced oxidative stress and inflammatory reaction in the rat brain

Cited by 28 publications

References 102 publications

Maternal Immune Activation Induces Neuroinflammation and Cortical Synaptic Deficits in the Adolescent Rat Offspring

Maternal Immune Activation Induces Neuroinflammation and Cortical Synaptic Deficits in the Adolescent Rat Offspring

Selenized Plant Oil Is an Efficient Source of Selenium for Selenoprotein Biosynthesis in Human Cell Lines

Reactive Oxygen Species and Selenium in Epilepsy and in Other Neurological Disorders

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