Self-targeted salinomycin-loaded DSPE-PEG-methotrexate Nanomicelles for Targeting Both Head and Neck Squamous Cell Carcinoma Cancer Cells and Cancer Stem Cells

Zhu, Minhui; Chen, Shicai; Hua, Libo; Zhang, Caiyun; Chen, Mengjie; Chen, Donghui; Dong, Yinmei; Zhang, Yingying; Li, Meng; Song, Xianmin; Chen, Huaiwen; Zheng, Hongliang

doi:10.2217/nnm-2016-0382

Cited by 19 publications

(15 citation statements)

References 43 publications

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“…Most nanoparticles which are larger than 50 nm accumulate around tumors primarily through the leaky vasculature of the tumor. On the contrary, particles with sizes below 50 nm have been shown to enter tumors more efficiently than their larger counterparts [ 89 ]. According to several reports, the hypoxic center and necrotic regions of tumors are rich in CSCs, therefore developing a drug delivery system with small size and enhanced penetration ability could facilitate the accumulation of anticancer drugs into the tumor [ 48 ].…”

Section: Types Of Drug Delivery Systems For Salinomycin (Sali)mentioning

confidence: 99%

“…In aqueous media, the hydrophobic segment faces the interior of the micelle, while the hydrophilic part forms an outer shell which protects and disperses drugs with poor solubility in water [ 90 ]. It is noteworthy that micelles could be designed to possess small sizes (around 10 nm) for a better penetration into solid tumors [ 89 ]. Furthermore, nanomicelles offer several advantages as drug delivery vehicles such as solubilization of lipophilic drugs in their inner hydrophobic core, high stability, prolonged in vivo circulation time, sustained drug release, and lastly their ability to passively target tumors through the EPR effect [ 91 ].…”

Section: Types Of Drug Delivery Systems For Salinomycin (Sali)mentioning

confidence: 99%

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Salinomycin-Based Drug Delivery Systems: Overcoming the Hurdles in Cancer Therapy

et al. 2021

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Cancer stem cells (CSCs) are reportedly responsible for the initiation and propagation of cancer. Since CSCs are highly resistant to conventional chemo- and radiotherapy, they are considered the main cause of cancer relapse and metastasis. Salinomycin (Sali), an anticoccidial polyether antibiotic, has emerged as a promising new candidate for cancer therapy, with selective cytotoxicity against CSCs in various malignancies. Nanotechnology provides an efficient means of delivering Sali to tumors in view of reducing collateral damage to healthy tissues and enhancing the therapeutic outcome. This review offers an insight into the most recent advances in cancer therapy using Sali-based nanocarriers.

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Section: Types Of Drug Delivery Systems For Salinomycin (Sali)mentioning

confidence: 99%

Section: Types Of Drug Delivery Systems For Salinomycin (Sali)mentioning

confidence: 99%

Salinomycin-Based Drug Delivery Systems: Overcoming the Hurdles in Cancer Therapy

et al. 2021

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“…SAL-loaded DSPE-PEG-methotrexate nanoparticles significantly suppress tumor growth in head and neck squamous cell carcinoma. 42 In addition, codelivery of SAL and doxorubicin using nanoliposomes significantly decreases the percentage of HCC-CSCs in vivo. 43 …”

Section: Discussionmentioning

confidence: 99%

<p>Salinomycin-Loaded Small-Molecule Nanoprodrugs Enhance Anticancer Activity in Hepatocellular Carcinoma</p>

Wang¹,

Zhuo²,

Tao³

et al. 2020

IJN

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Background There is currently no effective treatment for advanced hepatocellular carcinoma (HCC), and chemotherapy has little effect on long-term survival of HCC patients, largely due to the cancer stem cell (CSC) chemoresistance of HCC. Methods We constructed a small-molecule nanometer-sized prodrug (nanoprodrug) loaded with salinomycin (SAL) for the treatment of HCC. SAL was encapsulated by the prodrug LA-SN38 (linoleic acid modified 7-ethyl-10-hydroxycamptothecin) to construct a self-assembled nanoprodrug further PEGylated with DSPE-PEG 2000 . We characterized this codelivered nanoprodrug and its antitumor activity both in vitro in human HCC cell lines and in vivo in mice. Results Delivery of the SAL- and LA-SN38-based nanoprodrugs effectively promoted apoptosis of HCC cells, exerted inhibition of HCC tumor-sphere formation as well as HCC cell motility and invasion, and reduced the proportion of CD133+ HCC-CSC cells. In nude mice, the nanoprodrug suppressed growth of tumor xenografts derived from human cell lines and patient. Conclusion Our results show that SAL-based nanoprodrugs are a promising platform for treating patients with HCC and a novel strategy for combination therapy of cancers.

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“…The current chemotherapeutic drugs used to treat oral cancer are cisplatin (DDP) (Pendleton and Grandis, 2013;Jiang et al, 2020), fluorouracil (5-FU) (Vodenkova et al, 2020), docetaxel (Cui et al, 2020), paclitaxel (Harada et al, 2014), and methotrexate (Zhu et al, 2017). The oral route is the best approach for the administration of drugs to the body.…”

Section: Introductionmentioning

confidence: 99%

Research Progress and Prospect of Nanoplatforms for Treatment of Oral Cancer

Zhao

et al. 2020

Front. Pharmacol.

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Oral cancers refer to malignant tumors associated with high morbidity and mortality, and oral squamous cell carcinoma accounts for the majority of cases. It is an important part of head and neck, and oral cancer is one of the six most common cancers in the world. At present, the traditional treatment methods for oral cancer include surgery, radiation therapy, and chemotherapy. However, these methods have many disadvantages. In recent years, nanomedicine, the delivery of drugs through nanoplatforms for the treatment of cancer, has become a promising substitutive therapy. The use of nanoplatforms can reduce the degradation of the drug in the body and accurately deliver it to the tumor site. This minimizes the distribution of the drug to other organs, thereby reducing its toxicity and allowing higher drug concentration at the tumor site. This review introduces polymer nanoparticles, lipid-based nanoparticles, metal nanoparticles, hydrogels, exosomes, and dendrimers for the treatment of oral cancer, and discusses how these nanoplatforms play an anti-cancer effect. Finally, the review gives a slight outlook on the future prospects of nanoplatforms for oral cancer treatment.

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Self-targeted salinomycin-loaded DSPE-PEG-methotrexate Nanomicelles for Targeting Both Head and Neck Squamous Cell Carcinoma Cancer Cells and Cancer Stem Cells

Cited by 19 publications

References 43 publications

Salinomycin-Based Drug Delivery Systems: Overcoming the Hurdles in Cancer Therapy

Salinomycin-Based Drug Delivery Systems: Overcoming the Hurdles in Cancer Therapy

<p>Salinomycin-Loaded Small-Molecule Nanoprodrugs Enhance Anticancer Activity in Hepatocellular Carcinoma</p>

Research Progress and Prospect of Nanoplatforms for Treatment of Oral Cancer

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