Self-Supported Methoxylation and Acetoxylation Electrosynthesis Using a Simple Thin-Layer Flow Cell

Abstract

Self-supported electrochemical methoxylation and acetoxylation of various organic molecules were carried out using a thin-layer flow cell without intentionally added supporting electrolyte. The thin-layer flow cell employed in this work had a simple geometry with working and auxiliary electrodes directly facing each other with 80 m distance. Controlling factors for these kinds of self-supported electrochemical methoxylation and acetoxylation, such as the electrode material, the current density, and the flow rate were optimized to allow moderate to high yields of the corresponding methoxylated and acetoxylated products to be achieved in single flow-through operations.

Electrochemical Reactions in Microreactors

“…In this case, a glassy carbon anode and a platinum cathode directly faced each other at a distance of 80 mm (Figure 9.4) [22,23]. 2,5-Dimethoxy-2,5-dihydrofuran was obtained in 98% yield.…”

Towards paired and coupled electrode reactions for clean organic microreactor electrosyntheses

“…Flow through systems have been proposed with channel geometry [27] or with flow through porous plug electrodes [28]. Rather than employing a flow-through system with anode and cathode placed vis-a`-vis, electrode geometries such as the interdigitated electrode array can be highly effective [29] (see Figure 2a).…”

“…In a micro-flow cell with a carbon anode and platinum cathode this process is also possible under coupled diffusion layer conditions. Horii et al [27] have demonstrated that quantitative conversion of furan to 2,5-dimethoxy-2,5-dihydrofuran is possible even in the absence of added supporting electrolyte ( Figure 27). An inter-electrode gap of 80 lm was employed and the flow rate optimised.…”

“…Schematic presentation of the paired and coupled anodic methoxylation of furan in a micro flow cell[27].…”

Sodium Salts Dissolution in an Aprotic Solvent by Coordination of Poly(ethylene glycol) for Effective Anodic Reactions of Organic Compounds

“…Modern strategies of electroorganic synthesis 2 focus on reducing the amount of supporting electrolyte by using solid polymer elecrolyte (SPE), 3,4 microflow reactors, 5,6 polymersupported base, 7,8 and ionic lquids. 8,9 These approaches well contributed to the development of green electrode process; however, each reaction systems is somewhat specialized.…”