Self-supervised Denoising via Diffeomorphic Template Estimation: Application to Optical Coherence Tomography

Gisbert, Guillaume; Dey, Neel; Ishikawa, Hiroshi; Schuman, Joel S.; Fishbaugh, James; Gerig, Guido

doi:10.1007/978-3-030-63419-3_8

Cited by 2 publications

(2 citation statements)

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“…Also, recent work has shown that CNN-based denoising approaches can lead to good results. 22 In this study, we focused on patients with AMD. However, we have shown in our prior study that SELFF-OCT can access also detect relevant biomarkers in patients with diabetic macular oedema and retinal vein occlusion, so that home monitoring for these and possibly other diseases could be an option.…”

Section: Discussionmentioning

confidence: 99%

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Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study

et al. 2022

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ObjectivesSelf-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) is a novel OCT technology that was specifically designed for home monitoring of neovascular age-related macular degeneration (AMD). First clinical findings have been reported before. This trial investigates an improved prototype for patients with AMD and focusses on device operability and diagnostic accuracy compared with established spectral-domain OCT (SD-OCT).DesignProspective single-arm diagnostic accuracy study.SettingTertiary care centre (University Eye Clinic).Participants46 patients with age-related macular degeneration.InterventionsPatients received short training in device handling and then performed multiple self-scans with the SELFF-OCT according to a predefined protocol. Additionally, all eyes were examined with standard SD-OCT, performed by medical personnel. All images were graded by at least 2 masked investigators in a reading centre.Primary outcome measureRate of successful self-measurements.Secondary outcome measuresSensitivity and specificity of SELFF-OCT versus SD-OCT for different biomarkers and necessity for antivascular endothelial growth factor (anti-VEGF) treatment.ResultsIn 86% of all examined eyes, OCT self-acquisition resulted in interpretable retinal OCT volume scans. In these patients, the sensitivity for detection of anti-VEGF treatment necessity was 0.94 (95% CI 0.79 to 0.99) and specificity 0.95 (95% CI 0.82 to 0.99).ConclusionsSELFF-OCT was used successfully for retinal self-examination in most patients, and it could become a valuable tool for retinal home monitoring in the future. Improvements are in progress to reduce device size and to improve handling, image quality and success rates.Trial registration numberDRKS00013755, CIV-17-12-022384.

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Section: Discussionmentioning

confidence: 99%

“…In addition, the image quality of SELFF-OCT can be improved, which has a positive effect on interpretability. Also, recent work has shown that CNN-based denoising approaches can lead to good results 22…”

Section: Discussionmentioning

confidence: 99%