The long-term deterioration of large-scale infrastructure systems is a critical national problem that if left unchecked, could lead to catastrophes similar in magnitude to the collapse of the I-35W Bridge. Fortunately, the past decade has witnessed the emergence of a variety of sensing technologies from many engineering disciplines including from the civil, mechanical and electrical engineering fields. This paper provides a detailed overview of an emerging set of sensor technologies that can be effectively used for health management of large-scale infrastructure systems. In particular, the novel sensing technologies are integrated to offer a comprehensive monitoring system that fundamentally addresses the limitations associated with current monitoring systems (for example, indirect damage sensing, cost, data inundation and lack of decision making tools). Self-sensing materials are proposed for distributed, direct sensing of specific damage events common to civil structures such as cracking and corrosion. Data from self-sensing materials, as well as from more traditional sensors, are collected using ultra low-power wireless sensors powered by a variety of power harvesting devices fabricated using microelectromechanical systems (MEMS). Data collected by the wireless sensors is then seamlessly streamed across the internet and integrated with a database upon which finite element models can be autonomously updated. Life-cycle and damage detection analyses using sensor and processed data are streamed into a decision toolbox which will aid infrastructure owners in their decision making.