Self-stimulation of the habenular complex in the rat.

Sutherland, Robert J.; Nakajima, Shinshu

doi:10.1037/h0077833

Cited by 71 publications

(30 citation statements)

References 39 publications

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“…No such suppression was observed, but it is possible that avoidance responding had simply become habitual by this point and difficult to modify. In conclusion, although there is no evidence of an aversive effect of LHb stimulation in our study or in the literature (Sutherland and Nakajima, 1981), we cannot rule out this explanation.…”

Section: Discussioncontrasting

confidence: 50%

“…This led the authors to hypothesize that the LHb could block reinforcement signals originating in the VTA. Supporting evidence for this hypothesis came from Sutherland and Nakajima (1981), who found that lesioning the LHb increased rates of MFB self-stimulation, and from Christoph et al (1986), who first showed that electrical stimulation of the LHb inhibits 91% of VTA dopaminergic neurons, a finding recently replicated in the rat (Ji and Shepard, 2007) and extended to the primate (Matsumoto and Hikosaka, 2007). Thus, the LHb and VTA engage in a mutually inhibitory relationship, with activation of the dopaminergic reward system suppressing the LHb and activation of the LHb suppressing the dopaminergic reward system.…”

Section: Discussionmentioning

confidence: 76%

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Differential Neuromodulation of Acquisition and Retrieval of Avoidance Learning by the Lateral Habenula and Ventral Tegmental Area

Shumake¹,

Ilango²,

Scheich³

et al. 2010

J. Neurosci.

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Several studies suggest an opponent functional relationship between the lateral habenula (LHb) and the ventral tegmental area (VTA). Previous work has linked LHb activation to the inhibition of dopaminergic neurons during loss of reward, as well as to deficits in escape and avoidance learning. We hypothesized that a dopamine signal might underlie the negative reinforcement of avoidance responses and that LHb activation could block this signal and thereby cause avoidance deficits. To test this idea, we implanted stimulating electrodes in either the VTA or LHb of gerbils engaged in two-way active avoidance learning, a task that shows learning-associated dopamine changes and that is acquired faster following LHb lesions. We delivered brief electrical brain stimulation whenever the animal performed a correct response, i.e., when the successful avoidance of foot shock was hypothesized to trigger an intrinsic reward signal. During the acquisition phase, VTA stimulation improved avoidance performance, while LHb stimulation impaired it. VTA stimulation appeared to improve both acquisition and asymptotic performance of the avoidance response, as VTA-stimulated animals reached above-normal performance but reverted to normal responding when stimulation was discontinued. The effects of LHb stimulation during avoidance acquisition were long lasting and persisted even after stimulation was discontinued. However, when given after successful acquisition of avoidance behavior, LHb stimulation had no effect, indicating that LHb stimulation specifically impaired avoidance acquisition without affecting memory retrieval or motivation or ability to perform the avoidance response. These results demonstrate opponent roles of LHb and VTA during acquisition but not during retrieval of avoidance learning.

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Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 76%

Differential Neuromodulation of Acquisition and Retrieval of Avoidance Learning by the Lateral Habenula and Ventral Tegmental Area

Shumake¹,

Ilango²,

Scheich³

et al. 2010

J. Neurosci.

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“…This issue will be discussed in more detail at the end of this paper. In the forebrain, self-stimulation was supported at moderate to high rates in the lateral hypothalamic MFB and zona incerta, the perifornical lateral hypothalamus, and the habenula and its efferent pathway, the fasciculus retroflexus (Huang and Routtenberg, 1971;Steiner et al, 1978;Sutherland and Nakajima, 1981).…”

Section: The Extended Amygdala As An Interface Between Amygdaloid Andmentioning

confidence: 98%

The central extended amygdala network as a proposed circuit underlying reward valuation

Waraczynski

2006

Neuroscience & Biobehavioral Reviews

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“…Consistent with such widespread influences, it is implicated in diverse functions including anxiety (Murphy et al, 1996;Kurumaji et al, 2003), stress (Amat et al, 2001;Sica et al, 2000), analgesia (Cohen and Melzack, 1993), maternal behavior (Corodimas et al, 1993;Felton et al, 1998), sleep (Haun et al, 1992;Valjakka et al, 1998), behavioral flexibility (Thornton and Evans, 1982), reinforcement (Sutherland and Nakajima, 1981), and spatial memory (Lecourtier et al, 2004). The recent description of 15 subnuclei within the habenular complex (Andres et al, 1999;Geisler et al, 2003) should eventually be of great assistance for future research aimed at elucidating the particular circuits that mediate these specific behaviors.…”

Section: Introductionmentioning

confidence: 98%

Bilateral Lesions of the Habenula Induce Attentional Disturbances in Rats

Lecourtier

Kelly

2004

Neuropsychopharmacol

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The habenular nuclear complex is a major influence on brainstem cell groups that influence attention, but its role in attentional performance has not previously been explored. The present study investigated how habenula lesions affect attentional function as assessed by the 5-choice serial reaction time task (5-CSRTT) in male Lister-Hooded rats. Rats were pretrained in the 5-CSRTT before receiving discrete bilateral lesions of the habenula or a sham procedure. In test sessions immediately following recovery from surgery, lesioned rats showed a marked increase in premature responding. Over the course of testing this increase of premature responding declined in magnitude. In contrast, choice accuracy showed no impairment during the earliest postsurgery test sessions but progressively deteriorated over the course of testing. These opposite time courses strongly imply that different mechanisms mediate these two effects of the habenula lesion. Differential effects of drug treatment on these effects further supported this view. Thus, D-amphetamine (0.2 mg/ kg s.c.) increased premature responding without affecting choice accuracy. On the other hand, haloperidol (0.01-0.03 mg/kg i.p.) decreased premature responding without significantly affecting choice accuracy. The results are consistent with the view that elevated premature responding in habenula-lesioned animals is mediated by increased dopaminergic activity, whereas impaired choice accuracy is not. Implications of these findings for the hypothesis that habenula dysfunction is involved in cognitive symptoms of schizophrenia are discussed.

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Self-stimulation of the habenular complex in the rat.

Cited by 71 publications

References 39 publications

Differential Neuromodulation of Acquisition and Retrieval of Avoidance Learning by the Lateral Habenula and Ventral Tegmental Area

Differential Neuromodulation of Acquisition and Retrieval of Avoidance Learning by the Lateral Habenula and Ventral Tegmental Area

The central extended amygdala network as a proposed circuit underlying reward valuation

Bilateral Lesions of the Habenula Induce Attentional Disturbances in Rats

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