Self-sorting of equilibrating metallosupramolecular DCLs via constitutional crystallization

Abstract

Zn(2+) and Pb(2+) and ligands and self-assemble in solution to generate DCLs of interexchanging metallosupramolecular subcomponents, which convert into robust species of unique stoichiometry via constitutional crystallization.

Direct STD NMR Identification of β‐Galactosidase Inhibitors from a Virtual Dynamic Hemithioacetal System

“…Reversible covalent and noncovalent interactions are thus used for component assembly into discrete constituents, resulting in complex systems of an adaptive nature. The exploration of such systems is under rapid development, [2] and the implementation of complex processes are emerging. [3,4] Despite growing interest in the scientific community for dynamic systems, the restricted number of biocompatible, dynamic covalent processes available remains a limitation.…”

Chiral superstructures from homochiral Zn2+, Co2+, Fe2+‐2,6‐bis (aryl ethylimine)pyridine complexes

“…The 1 H‐NMR spectra of the 1 ‐Λ‐(S,S,S,S)‐Zn 2+ / 1 ‐∆‐(R,R,R,R)‐Zn 2+ and 2 ‐Λ‐(S,S,S,S)‐Zn 2+ / 2 ‐∆‐(R,R,R,R)‐Zn 2+ homonuclear complexes (Figures S1 and S2) consist of a series of well‐defined peaks characteristic to the 1:2 symmetric metal‐ligand complex. In these spectra, the H a pyridine protons signals of the ligand appear shifted to the weaker magnetic field than the signals corresponding to these protons in similar free bis ( aryl imine) pyridine ligands . Tridentate metal ion coordination determine the ligands to adopt during the template synthesis a cisoid conformation, corresponding to a terpyridine (terpy) type coordination site.…”

“…Tridentate metal ion coordination determine the ligands to adopt during the template synthesis a cisoid conformation, corresponding to a terpyridine (terpy) type coordination site. The conversion of the all‐transoid conformer into the energetically disfavoured all‐cisoid one upon metal complexation occurs at the cost of conformational energy, which is overcompensated by the interaction energy resulting from metal ion binding …”

“…There are a few previous examples of direct crystallization of enantiopure helical supramolecular single crystals, more often the crystal is racemic since homochiral layers of opposite chirality could be present and connected via different chirality inverting interactions. Examples of homochiral supramolecular helices were reported by us, in our previous work on complexes of Zn 2+ , Co 2+ , Fe 2+ , Pb 2+ metal ions with bis ( arene imine)pyridines ligands, but these examples are exclusively based on achiral ligands , and the resulted solid‐state chirality is promoted by constitutional chiral affinity of supramolecular helices of the same handedness, interacting via their van der Waals hypersurfaces. 51a…”

Deconvolution of a multi-component interaction network using systems chemistry

“…We, and others [24][25][26][27][28][29][30][31][32][33][34][35], refer to such systems as self-sorting systems. For example, we selected 10 compounds from the literature well known to form supramolecular aggregates driven by H-bonding interactions and showed that this collection of aggregates forms even when all 10 components are mixed [36].…”