Self‐resolving superficial primary cutaneous mucormycosis in a 7‐week‐old infant

Jones, Milissa; Flores, Michelle S.; Vereen, Rasheda J.; Szabo, Sabrina R; Logemann, Nicholas; Eberly, Matthew D.

doi:10.1111/pde.13531

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…This situation completely differs from self-resolving superficial mucormycosis reported in very superficial fungal infections. 4 Although the patient and her family did not recall the cause, direct inoculation would be the more plausible wayin a predisposed patient. Cultures were negative, a rare finding, but primary cutaneous mucormycosis by R. variabilis, unlike other mucorales, presents as chronic infections with infiltrated plaques, ulcers and nodules, which usually remain localized and gradually expand over months and years.…”

Section: Discussionmentioning

confidence: 99%

Necrotizing panniculitis secondary to primary cutaneous localized mucormycosis

Velasco¹

2021

JDC

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Primary cutaneous mucormycosis is a rare entity that affects more frequently extremities of immunosuppressed patients and may be gradual in onset or fulminant. An 83-year-old female with diabetes mellitus presented a nodular lesion in the forearm, which had progressed during one month. Clinically, as the lesion was indolent and followed a linear trajectory, a superficial phlebitis was suspected but later ruled out. Skin blood cultures were negative. Skin biopsy showed a necrotic panniculitis with isolated ghost adipocytes and presence of irregularly branched hyphae involving dermis and some vessels that could be stained with PAS and Grocott, thus leading to the diagnosis of primary cutaneous localized mucormycosis. This case is noteworthy as indolent course in primary cutaneous mucormycosis with vascular involvement is rather rare. Even with a negative culture, R. Variabilis is a candidateetiologic agent as it usually presents a chronic evolution. Histopathologically, most panniculitis related to fungal infection are reportedas pancreatic panniculitis mimickers. In our case, only scarce ghost adipocytes were found and the main histopathological findings were a lobular panniculitis with vasculitis and an extensive basophilic necrosis. Thus, these histopathologic findings should raise suspicion of infection related-panniculitis, and PAS and Grocott stainings should be performed to rule out fungi.

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Section: Discussionmentioning

confidence: 99%

Necrotizing panniculitis secondary to primary cutaneous localized mucormycosis

Velasco¹

2021

JDC

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Global Cutaneous Mucormycosis: A Systematic Review

Skiada

Drogari‐Apiranthitou

Pavleas

et al. 2022

JoF

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Cutaneous mucormycosis is the third most common clinical type of mucormycosis. The signs and symptoms vary widely, and it is important to make the diagnosis as early as possible in order to achieve a better outcome. We present a systematic review of its epidemiology, clinical presentation, diagnosis, and treatment, analyzing cases published from 1958 until 2021. The review was conducted according to the PRISMA guidelines and included 693 cases from 485 articles from 46 countries. Most publications were from North America (256 cases, 36.9%) and Asia (216 cases, 31.2%). The most common risk factors were diabetes mellitus (20%) and hematological malignancies (15.7%). However, a large proportion of published cases (275, 39.6%) had no identified underlying disease. The most common mode of transmission was trauma (54%), and 108 (15.6%) cases were healthcare-associated. In this review, 291 (42.5%) patients had localized infection, and 90 (13%) had disseminated mucormycosis. In Europe, N. America and S. America, the most common genus was Rhizopus spp., while in Asia it was Apophysomyces spp. (34.7%). Treatment was performed with antifungals, mainly amphotericin B, and/or surgery. Mortality was significantly lower when both antifungals and surgery were applied (29.6%).

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Self‐resolving superficial primary cutaneous mucormycosis in a 7‐week‐old infant

Cited by 2 publications

References 5 publications

Necrotizing panniculitis secondary to primary cutaneous localized mucormycosis

Necrotizing panniculitis secondary to primary cutaneous localized mucormycosis

Global Cutaneous Mucormycosis: A Systematic Review

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