Self-Reported Visual Complaints in People with Parkinson’s Disease: A Systematic Review

Lijn, Iris van der; Haan, Gera de; Huizinga, Famke; Feen, Fleur E. van der; Rutgers, A.W.F.; Stellingwerf, Catharina; Laar, Teus van; Heutink, Joost

doi:10.3233/jpd-202324

Cited by 8 publications

(13 citation statements)

References 159 publications

(112 reference statements)

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“…Visual complaints were more prevalent in people with PD compared to controls, consistent with previous findings [ 2 ]. All 19 complaints were more prevalent in people with PD compared to controls, and 16 complaints showed significant differences.…”

Section: Discussionsupporting

confidence: 92%

“…Visual problems are increasingly recognized as part of the symptomatology of Parkinson’s disease (PD) [ 1 ]. The presence of visual problems may have a vast impact on the quality of life of people with PD [ 2 , 3 ]. Vision is essential for the performance of most daily life activities, e.g., reading or mobility-related tasks such as driving.…”

Section: Introductionmentioning

confidence: 99%

“…However, in scientific literature and clinical practice, visual complaints of people with PD are often underreported and unrecognized [ 4 , 8 ]. A recent systematic review on visual complaints in people with PD indicated that literature on this topic is still scarce [ 2 ]. Most studies had small sample sizes and examined only one or few visual complaints.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and nature of self-reported visual complaints in people with Parkinson’s disease—Outcome of the Screening Visual Complaints questionnaire

et al. 2023

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Introduction Visual complaints can have a vast impact on the quality of life of people with Parkinson’s disease (PD). In clinical practice however, visual complaints often remain undetected. A better understanding of visual complaints is necessary to optimize care for people with PD and visual complaints. This study aims at determining the prevalence of visual complaints experienced by a large outpatient cohort of people with PD compared to a control group. In addition, relations between visual complaints and demographic and disease-related variables are investigated. Methods The Screening Visual Complaints questionnaire (SVCq) screened for 19 visual complaints in a cohort of people with idiopathic PD (n = 581) and an age-matched control group without PD (n = 583). Results People with PD experienced significantly more complaints than controls, and a greater impact of visual complaints on their daily lives. Complaints that were most common (‘often/always’) were unclear vision (21.7%), difficulty reading (21.6%), trouble focusing (17.1%), and blinded by bright light (16.8%). Largest differences with controls were found for double vision, needing more time to see and having trouble with traffic participation due to visual complaints. Age, disease duration, disease severity, and the amount of antiparkinsonian medication related positively to the prevalence and severity of visual complaints. Conclusion Visual complaints are highly prevalent and occur in great variety in people with PD. These complaints progress with the disease and have a large impact on the daily lives of these people. Standardized questioning is advised for timely recognition and treatment of these complaints.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence and nature of self-reported visual complaints in people with Parkinson’s disease—Outcome of the Screening Visual Complaints questionnaire

et al. 2023

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“…Although an association of hearing loss with Alzheimer disease has long been recognized, this has only rarely been reported for PD . Subjective visual complaints, which are also common in PD, were not a common feature associated with subsequent PD. Unspecified pain, another common sensory feature of PD, was present in a large number of patients before the diagnosis of PD and more common than in controls in all examined time periods as has been previously reported .…”

Section: Discussionmentioning

confidence: 96%

Widening the Spectrum of Risk Factors, Comorbidities, and Prodromal Features of Parkinson Disease

Schrag

Bohlken

Dammertz³

et al. 2023

JAMA Neurol

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ImportanceThe prodromal phase of Parkinson disease (PD) may last for more than 10 years. Recognition of the spectrum and occurrence of risk factors, comorbidities, and prodromal features of PD can increase understanding of the causes and development of the disease and help identify individuals at risk.ObjectiveTo identify the association of a subsequent diagnosis of PD with a range of risk factors and prodromal features, including lifestyle factors, comorbidities, and potential extracerebral manifestations of PD.Design, Setting, and ParticipantsThis was a case-control study using insurance claims of outpatient consultations of patients with German statutory health insurance between January 1, 2011, and December 31, 2020. Included were patients with incident diagnosis of PD without a previous diagnosis of parkinsonism or dementia and controls matched 1:2 for age, sex, region, and earliest year of outpatient encounter.ExposuresExposures were selected based on previous systematic reviews, case-control and cohort studies reporting on risk factors, comorbidities, and prodromal features of PD.Main Outcomes and MeasuresPreviously postulated risk factors and prodromal features of PD, using the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) coding.ResultsA total of 138 345 patients with incident PD (mean [SD] age, 75.1 [9.8] years; 73 720 male [53.3%]) and 276 690 matched controls (mean [SD] age, 75.1 (9.8) years; 147 440 male [53.3%]) were identified. Study participants were followed up for a mean (SD) of 6.0 (2.0) years. Consistent with previous reports, risk factors and prodromal features associated with PD included traumatic brain injury, odds ratio (OR), 1.62; 95% CI, 1.36-1.92; alcohol misuse, OR, 1.32; 95% CI, 1.21-1.44; hypertension, OR, 1.29; 95% CI, 1.26-1.31; anosmia, OR, 2.16; 95% CI, 1.59-2.93; and parasomnias (including RBD), OR, 1.62; 95% CI, 1.42-1.84. In addition, there were associations with restless legs syndrome (OR, 4.19; 95% CI, 3.91-4.50), sleep apnea (OR, 1.45; 95% CI, 1.37-1.54), epilepsy (OR, 2.26; 95% CI, 2.07-2.46), migraine (OR, 1.21; 95% CI, 1.12-1.29), bipolar disorder (OR, 3.81; 95% CI, 3.11-4.67), and schizophrenia (OR, 4.48; 95% CI, 3.82-5.25). The following diagnoses were also found to be associated with PD: sensory impairments beyond anosmia, such as hearing loss (OR, 1.14; 95% CI, 1.09-1.20) and changes of skin sensation (OR, 1.31; 95% CI, 1.21-1.43). There were also positive associations with skin disorders (eg, seborrheic dermatitis, OR, 1.30; 95% CI, 1.15-1.46; psoriasis, OR, 1.13; 95% CI, 1.05-1.21), gastrointestinal disorders (eg, gastroesophageal reflux, OR, 1.29; 95% CI, 1.25-1.33; gastritis, OR, 1.28; 95% CI, 1.24-1.33), conditions with a potential inflammatory component (eg, seronegative osteoarthritis, OR, 1.21; 95% CI, 1.03-1.43), and diabetes types 1 (OR, 1.32; 95% CI, 1.21-1.43) and 2 (OR, 1.24; 95% CI, 1.20-1.27). Associations even 5 to 10 years before diagnosis included tremor (odds ratio [OR], 4.49; 95% CI, 3.98-5.06), restless legs syndrome (OR, 3.73; 95% CI, 3.39-4.09), bipolar disorder (OR, 3.80; 95% CI, 2.82-5.14), and schizophrenia (OR, 4.00; 95% CI, 3.31-4.85).Conclusions and RelevanceResults of this case-control study suggest that the associations found between PD and certain risk factors, comorbidities, and prodromal symptoms in a representative population may reflect possible early extrastriatal and extracerebral pathology of PD. This may be due to shared genetic risk with PD, medication exposure, or direct causation, or represent pathophysiologically relevant factors contributing to the pathogenesis of PD.

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“…Visual problems are highly frequent in people with Parkinson’s disease (PD) [ 1 , 2 ]. These problems can interfere with a wide variety of daily activities and therefore negatively affect quality of life.…”

Section: Introductionmentioning

confidence: 99%

The Screening Visual Complaints questionnaire (SVCq) in people with Parkinson’s disease—Confirmatory factor analysis and advice for its use in clinical practice

Lijn

Haan²,

Feen³

et al. 2022

PLoS ONE

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Background The Screening Visual Complaints questionnaire (SVCq) is a short questionnaire to screen for visual complaints in people with Parkinson’s disease (PD). Objective The current study aims to investigate the factor structure of the SVCq to increase the usability of this measure in clinical practice and facilitate the interpretation of visual complaints in people with PD. Methods We performed a confirmatory factor analysis using the 19 items of the SVCq of 581 people with PD, investigating the fit of three models previously found in a community sample: a one-factor model including all items, and models where items are distributed across either three or five factors. The clinical value of derived subscales was explored by comparing scores with age-matched controls (N = 583), and by investigating relationships to demographic and disease related characteristics. Results All three models showed a good fit in people with PD, with the five-factor model outperforming the three-factor and one-factor model. Five factors were distinguished: ‘Diminished visual perception–Function related’ (5 items), ‘Diminished visual perception–Luminance related’ (3 items), ‘Diminished visual perception–Task related’ (3 items), ‘Altered visual perception’ (6 items), and ‘Ocular discomfort’ (2 items). On each subscale, people with PD reported more complaints than controls, even when there was no ophthalmological condition present. Furthermore, subscales were sensitive to relevant clinical characteristics, like age, disease duration, severity, and medication use. Conclusions The five-factor model showed a good fit in people with PD and has clinical relevance. Each subscale provides a solid basis for individualized visual care.

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Self-Reported Visual Complaints in People with Parkinson’s Disease: A Systematic Review

Cited by 8 publications

References 159 publications

Prevalence and nature of self-reported visual complaints in people with Parkinson’s disease—Outcome of the Screening Visual Complaints questionnaire

Prevalence and nature of self-reported visual complaints in people with Parkinson’s disease—Outcome of the Screening Visual Complaints questionnaire

Widening the Spectrum of Risk Factors, Comorbidities, and Prodromal Features of Parkinson Disease

The Screening Visual Complaints questionnaire (SVCq) in people with Parkinson’s disease—Confirmatory factor analysis and advice for its use in clinical practice

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