Self‐reported use of natural health products among rheumatology patients: A cross‐sectional survey

Hall, Jill; Dissanayake, Tharindri D.; Lau, Darren; Katz, Steven J.

doi:10.1002/msc.1178

Cited by 6 publications

(6 citation statements)

References 19 publications

(34 reference statements)

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“…Therefore, it is not surprising that the interest of scientists has been caught by complementary and different therapeutic strategies, specifically compounds of natural origin and nutraceuticals, which have gained interest in the management of RA, especially in elderly patients [24,25,26]. In fact, a growing number of patients seek remedy in natural compounds, because they believe that they are effective and safe [27,28].…”

Section: Discussionmentioning

confidence: 99%

β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-γ Receptors

et al. 2019

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β-caryophyllene (BCP) is a cannabinoid receptor 2 (CB2) agonist that tempers inflammation. An interaction between the CB2 receptor and peroxisome proliferator-activated receptor gamma (PPAR-γ) has been suggested and PPAR-γ activation exerts anti-arthritic effects. The aim of this study was to characterize the therapeutic activity of BCP and to investigate PPAR-γ involvement in a collagen antibody induced arthritis (CAIA) experimental model. CAIA was induced through intraperitoneal injection of a monoclonal antibody cocktail and lipopolysaccharide (LPS; 50 μg/100 μL/ip). CAIA animals were then randomized to orally receive either BCP (10 mg/kg/100 μL) or its vehicle (100 μL of corn oil). BCP significantly hampered the severity of the disease, reduced relevant pro-inflammatory cytokines, and increased the anti-inflammatory cytokine IL-13. BCP also decreased joint expression of matrix metalloproteinases 3 and 9. Arthritic joints showed increased COX2 and NF-ĸB mRNA expression and reduced expression of the PPARγ coactivator-1 alpha, PGC-1α, and PPAR-γ. These conditions were reverted following BCP treatment. Finally, BCP reduced NF-ĸB activation and increased PGC-1α and PPAR-γ expression in human articular chondrocytes stimulated with LPS. These effects were reverted by AM630, a CB2 receptor antagonist. These results suggest that BCP ameliorates arthritis through a cross-talk between CB2 and PPAR-γ.

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Section: Discussionmentioning

confidence: 99%

β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-γ Receptors

et al. 2019

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“…Information about specific HMPs and herbal supplements used by patients with rheumatoid arthritis (RA), chronic inflammatory bowel diseases (IBD), or osteoarthritis are scarce. Most surveys on complementary and alternative therapy or supplement use by those patients did not ask for the species used [ 4 , 19 , 29 ] or were conducted outside of the geographical area of this review [ 30 , 31 , 32 ], or both [ 33 , 34 ].…”

Section: Assessment Of Herbal Drugs and Their Interactionsmentioning

confidence: 99%

“…The only plant listed as a joint-specific product was turmeric. It was used by 12 patients, or 3.1% of supplement users [ 32 ]. Skiba et al conducted a survey in southern Arizona (USA) that was completed by 696 adult patients diagnosed with rheumatoid arthritis [ 30 ].…”

Section: Assessment Of Herbal Drugs and Their Interactionsmentioning

confidence: 99%

Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements

Lippert

Renner

2022

JCM

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Many people worldwide use plant preparations for medicinal purposes. Even in industrialized regions, such as Europe, where conventional therapies are accessible for the majority of patients, there is a growing interest in and usage of phytomedicine. Plant preparations are not only used as alternative treatment, but also combined with conventional drugs. These combinations deserve careful contemplation, as the complex mixtures of bioactive substances in plants show a potential for interactions. Induction of CYP enzymes and pGP by St John’s wort may be the most famous example, but there is much more to consider. In this review, we shed light on what is known about the interactions between botanicals and drugs, in order to make practitioners aware of potential drug-related problems. The main focus of the article is the treatment of inflammatory diseases, accompanied by plant preparations used in Europe. Several of the drugs we discuss here, as basal medication in chronic inflammatory diseases (e.g., methotrexate, janus kinase inhibitors), are also used as oral tumor therapeutics.

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“…The use of dietary supplements is highly prevalent in individuals with arthritis including those with RA, since people perceive them to provide a higher degree of self-control over their health [43,44]. However, evidence pertaining to the efficacy, and safety of these supplements on RA symptoms is conflicting and of moderate strength [45,46].…”

Section: Diet and Nutrition Prevention Researchmentioning

confidence: 99%

Can Studying Genetically Predisposed Individuals Inform Prevention Strategies for RA?

et al. 2021

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Rheumatoid arthritis (RA) is a prevalent autoimmune disorder in which complex genetic predisposition interacts with multiple environmental factors to precipitate chronic and progressive immune-mediated joint inflammation. Currently, in most affected individuals, ongoing suppression of the inflammation is required to prevent irreversible damage and functional loss. The delineation of a protracted preclinical period in which autoimmunity is initially established and then evolves to become pathogenic provides unprecedented opportunities for interventions that have the potential to prevent the onset of this lifelong disease. Clinical trials aimed at assessing the impact of specific prevention strategies require the identification of individuals who are at high risk of future RA development. Currently, these risk factors include a strong family history of RA, and the detection of circulating RA-associated autoantibodies, particularly anti-citrullinated protein antibodies (ACPA). Yet, even in such individuals, there remains considerable uncertainty about the likelihood and the timeframe for future disease development. Thus, individuals who are approached to participate in such clinical trials are left weighing the risks and benefits of the prevention measures, while having large gaps in our current understanding. To address this challenge, we have undertaken longitudinal studies of the family members of Indigenous North American RA patients, this population being known to have a high prevalence of RA, early age of onset, and familial clustering of cases. Our studies have indicated that the concepts of “risk” and “prevention” need to be communicated in a culturally relevant manner, and proposed prevention interventions need to have an appropriate balance of effectiveness, safety, convenience, and cultural acceptability. We have focused our proposed prevention studies on immunomodulatory/anti-inflammatory nutritional supplements that appear to strike such a complex balance.

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Self‐reported use of natural health products among rheumatology patients: A cross‐sectional survey

Abstract: Our study confirms the frequent use of selected NHPs, possibly to mitigate persistent symptoms of rheumatologic illness. Rheumatologists appear to be trusted sources of advice and recommendations on NHP use and should provide balanced counselling for their patients.

Cited by 6 publications

References 19 publications

β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-γ Receptors

β-Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR-γ Receptors

Herb–Drug Interaction in Inflammatory Diseases: Review of Phytomedicine and Herbal Supplements

Can Studying Genetically Predisposed Individuals Inform Prevention Strategies for RA?

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