Self-reported symptoms of sleep disturbance and inflammation, coagulation, insulin resistance and psychosocial distress: Evidence for gender disparity

Suarez, Edward C.

doi:10.1016/j.bbi.2008.01.011

Cited by 216 publications

(202 citation statements)

References 68 publications

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“…This finding is in line with research suggesting that there are gender differences in the way women and men perceive sleep disturbances and how they react to such difficulties [11]. In general women are more likely to rely on their social network to get advice for sleep difficulties, while men are more likely to receive drugs and assistance in interpreting their symptoms from a lay referral system [10].…”

Section: Determinants Of Healthcare-seeking Behaviorssupporting

confidence: 86%

Insomnia and healthcare-seeking behaviors: impact of case definitions, comorbidity, sociodemographic, and cultural factors

Morin¹,

Jarrin²

2013

Sleep Medicine

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EditorialInsomnia and healthcare-seeking behaviors: impact of case definitions, comorbidity, and sociodemographic and cultural factorsThe public health significance of insomnia has received increased attention in the last two decades, as reflected by the numerous worldwide epidemiologic investigations documenting its prevalence, course, risk factors, and long-term outcomes. Cross-sectional studies have strengthened the evidence that insomnia is a prevalent health problem in the general population, and longitudinal studies also have more recently documented the persistent course of insomnia and its negative outcomes on mental (e.g., depression), physical (e.g., hypertension), and occupational health (e.g., disability) [1].The paper by Hsu et al [2] in this issue of Sleep Medicine provides additional insight into one of several important public health aspects of insomnia, that is, healthcare-seeking behaviors.Using insurance claims of over 900,000 enrollees of the National Health Insurance program in Taiwan, the authors examined the annual rates of outpatient and inpatient consultations for insomnia from 2002 to 2009. Point prevalence estimates of healthcare-seeking behaviors varied between 2.5% and 4.2% annually, with an increasing trend over the 8-year period, whereas incidence rates fluctuated between 1.3% and 1.6% for the same interval. Significant associations were observed between increased use of healthcare services for insomnia and female gender, middle and older ages, and the middle socioeconomic status, all of which adding to the knowledge base on healthcare-seeking behaviors. Although there were many strengths of this study, such as its use of a longitudinal design with repeated assessments, the large population-

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Section: Determinants Of Healthcare-seeking Behaviorssupporting

confidence: 86%

Insomnia and healthcare-seeking behaviors: impact of case definitions, comorbidity, sociodemographic, and cultural factors

Morin¹,

Jarrin²

2013

Sleep Medicine

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“…In a study on 210 healthy young men and women, difficulty falling asleep was related to higher morning levels of CRP and IL-6, but only in women (Suarez, 2008). Sleep disturbances also occur in up to 30% of patients with chronic hepatitis C undergoing IFN-α therapy (Sockalingam et al, 2010), and its administration reduces sleep continuity and depth and induces a sleep pattern consistent with insomnia and hyperarousal (Raison et al, 2010b).…”

Section: Sleep and Its Effect On Inflammationmentioning

confidence: 99%

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Lopresti

Hood

Drummond

2013

Journal of Affective Disorders

503

412

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Research on major depression has confirmed that it is caused by an array of biopsychosocial and lifestyle factors. Diet, exercise and sleep are three such influences that play a significant mediating role in the development, progression and treatment of this condition. This review summarises animal and human-based studies on the relationship between these three lifestyle factors and major depressive disorder, and their influence on dysregulated pathways associated with depression, namely neurotransmitter processes, immuno-inflammatory pathways, hypothalamic-pituitary-adrenal (HPA) axis disturbances, oxidative stress and antioxidant defence systems, neuroprogression, and mitochondrial disturbances. Increased attention in future clinical studies on the influence of diet, sleep and exercise on major depressive disorder and investigations of their effect on physiological processes will help to expand our understanding and treatment of major depressive disorder. Mental health interventions, taking into account the bidirectional relationship between these lifestyle factors and major depression are also likely to enhance the efficacy of interventions associated with this disorder.

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“…13,14 In the context of pregnancy, poor sleep quality has been implicated as a risk factor for preterm birth. [15][16][17][18] It has been postulated that inflammation may play a causal role in this association.…”

Section: -12mentioning

confidence: 99%

Poor Sleep Quality and Associated Inflammation Predict Preterm Birth: Heightened Risk among African Americans

Blair

Porter

Leblebicioğlu

et al. 2015

Sleep

159

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1259Sleep and Preterm Birth-Blair et al. INTRODUCTIONIn the United States, preterm birth affects 11.5% of deliveries and is the underlying cause of more than one third of infant deaths.1 A high proportion of surviving preterm infants suffer from severe physical and cognitive consequences, potentially requiring intensive medical and/or educational support throughout the lifespan.2 The morbidity and mortality associated with preterm birth pose significant drains on the financial and emotional resources of afflicted families, and on the nation as a whole, costing more than $26 billion annually in the United States. 3Inflammation is a causal mechanism in the initiation of preterm as well as term labor. 4 Inflammatory mediators can initiate contractions, encourage cervical ripening, and cause rupture of the membranes.4,5 Via these mechanisms, inflammation induced by infection or psychological stress may trigger early parturition. 6,7Importantly, poor sleep promotes inflammation.8 For example, in a population-based cohort of more than 5,000 adults, shorter sleep duration was associated with elevations in Study Objectives: Poor sleep promotes inflammation. In turn, inflammation is a causal mechanism in term as well as preterm parturition. In the United States, a persistent racial disparity in preterm birth exists, with African Americans showing ~1.5 times greater risk. This study examined associations among sleep quality, serum proinflammatory cytokines, and length of gestation in a racially diverse sample of 138 pregnant women. Design: Observational. Measurements: Women completed the Pittsburgh Sleep Quality Index (PSQI) and other psychosocial and behavioral measures during midpregnancy. Serum levels of interleukin (IL)-6, IL-8, IL-1β, and tumor necrosis factor (TNF)-α were determined by high-sensitivity assays. Birth outcomes were determined via medical record review. Results: Among African American women (n = 79), shorter gestation was predicted by poorer overall sleep (r s = −0.35, P = 0.002) as well the following PSQI subscales: subjective sleep quality (r s = −0.34, P = 0.002), sleep latency (r s = −0.27, P = 0.02), and sleep efficiency (r s = −0.27, P = 0.02). African American women with poor sleep quality (PSQI > 5) had 10.2 times the odds of preterm birth compared to those with good sleep quality. In contrast, among European American women (n = 53), gestational length was not significantly predicted by sleep quality (Ps > 0.12). Bootstrapping analyses showed that, among African Americans, IL-8 significantly mediated the association between sleep quality and length of gestation (indirect effect estimate −0.029; 95% confidence interval −0.06, −0.002). Conclusions:The data provide novel evidence that African American women exhibit greater inflammation in response to sleep disturbance than European American women and these effects correspond with length of gestation. Racial differences in susceptibility to sleep induced immune dysregulation may contribute to marked racial disparities in preterm birth.

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Self-reported symptoms of sleep disturbance and inflammation, coagulation, insulin resistance and psychosocial distress: Evidence for gender disparity

Cited by 216 publications

References 68 publications

Insomnia and healthcare-seeking behaviors: impact of case definitions, comorbidity, sociodemographic, and cultural factors

Insomnia and healthcare-seeking behaviors: impact of case definitions, comorbidity, sociodemographic, and cultural factors

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Poor Sleep Quality and Associated Inflammation Predict Preterm Birth: Heightened Risk among African Americans

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