Self-reported Sleep Impairment in Functional Dyspepsia and Irritable Bowel Syndrome

Kim, Seung Young; Choung, Rok Seon; Lee, Seung Ku; Choe, Jung Wan; Jung, Sung Woo; Hyun, Jong Jin; Koo, Ja Seol; Lee, Sang Woo; Shin, Chol

doi:10.5056/jnm17098

Cited by 36 publications

(30 citation statements)

References 45 publications

(46 reference statements)

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“…IBS is known to have significant impacts on the QoL of patients. 9,78 However, limited data are available as to whether the impact of IBS on life differs between women and men. 13 Simrén et al 79 found that women with IBS reported lower QoL; higher levels of fatigue, depression, and anxiety; and less positive well-being and self-control than men with IBS.…”

Section: Quality Of Lifementioning

confidence: 99%

Sex-Gender Differences in Irritable Bowel Syndrome

Kim

2018

J Neurogastroenterol Motil

182

127

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Because of the sex-gender differences that are shown in a diversity of physiological and psychological factors, it can be speculated that the clinical presentation of symptoms as well as treatment strategies in women and men with irritable bowel syndrome (IBS) may differ. Studies have revealed that IBS is more common in women than men. As for the IBS subtype, IBS with constipation is significantly more prevalent among women than men. Sex hormones and gender differences may play important roles in the pathophysiology of IBS. However, its pathophysiologic mechanisms still remain largely unknown, and therapeutic implications are limited. Moreover, women IBS patients have been reported to feel more fatigue, depression, anxiety, and lower quality of life than men IBS patients. Furthermore, there has been evidence of differences in the appropriate treatment efficacy to IBS in men and women, although relatively few men are enrolled in most relevant clinical trials. A more sex-gender-oriented approach in the medical care setting could improve understanding of heterogeneous patients suffering from IBS. An individualized and multicomponent approach including sex and gender issues might help improve the treatment of IBS.

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Section: Quality Of Lifementioning

confidence: 99%

Sex-Gender Differences in Irritable Bowel Syndrome

Kim

2018

J Neurogastroenterol Motil

182

127

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“…The few studies conducted in functional dyspepsia (FD) patients with sleep disturbances have reported inconsistent results. It has been reported that the prevalence of sleep disturbances is slightly higher in patients with FD than in healthy controls 8–12 ; moreover, sleep disturbances in patients with FD were more common in the presence of heartburn or regurgitation 13 . However, other studies reported that sleep disorders were not associated with FD 7,14,15 .…”

Section: Introductionmentioning

confidence: 99%

Sleep disorders in patients with functional dyspepsia: A multicenter study from the Korean Society of Neurogastroenterology and Motility

Park

Huh

Kwon

et al. 2020

J of Gastro and Hepatol

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Background and Aim The few studies concerning the association between sleep disorders and functional dyspepsia (FD) have yielded inconsistent results. We compared the prevalence of sleep disorders in patients with FD and healthy controls, and evaluated whether FD was independently associated with sleep disorders, and the risk factors for sleep disorders in patients with FD. Methods This prospective, multicenter, cross‐sectional study was conducted from August 2014 to December 2017 at 12 hospitals in South Korea. The inclusion criterion was the presence of FD (for ≥18 years) according to the Rome III criteria. Healthy controls were recruited from among patients who visited the Health Examination Center for check‐ups. Results In total, 526 subjects were prospectively enrolled in this study (201 with FD and 325 healthy controls). The prevalence of sleep disorders was significantly higher among the patients with FD than among the healthy controls (41.8% vs 18.8%, P = 0.000). In a multivariate analysis, FD (odds ratio [OR] = 1.851; 95% confidence interval [CI] 1.194–2.870; P = 0.006), female sex (OR = 1.672; 95% CI 1.063–2.628; P = 0.026), and anxiety (OR = 3.325; 95% CI 2.140–5.166; P = 0.000) were independent risk factors for sleep disorders in the overall cohorts. In patients with FD only, low body mass index, heartburn, and anxiety were independent risk factors for sleep disorders in a further multivariate analysis. Conclusion Sleep disorders were common in patients with FD. FD was significantly associated with sleep disorders in our patient population, irrespective of the presence of heartburn or psychiatric disorders.

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“…It is well known that many patients with functional gastrointestinal (GI) disorders have sleep disturbance [ 1 – 3 ]. Functional dyspepsia (FD) is a functional GI disease that is also frequently comorbid with sleep disturbance [ 4 , 5 ]. However, most studies have just pointed out an association between GI symptoms and sleep disturbance, and only a few studies have focused on how GI symptoms change by improvement of sleep disturbance.…”

Section: Introductionmentioning

confidence: 99%

Impact of improvement of sleep disturbance on symptoms and quality of life in patients with functional dyspepsia

et al. 2021

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Background/aims Functional dyspepsia (FD) is often comorbid with sleep disturbance. However, it is not fully understood how sleep disturbance affects the pathophysiology of FD. We aimed to investigate the relationship between FD and sleep disturbance. Methods We prospectively enrolled 20 FD patients with sleep disturbance between December 2018 and July 2019. Patients took sleep aids for 4 weeks and filled out questionnaires before and after taking sleep aids. Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and Athens Insomnia Scale (AIS) were used to evaluate the severity of their sleep disturbance. Modified Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (mFSSG), Gastrointestinal Symptom Rating Scale (GSRS), and the Japanese version of Patient Assessment of Constipation Quality of Life (JPAC-QOL) were used to evaluate the severity of GI symptoms. Short-Form 36-Item Health Survey (SF-36) was used to evaluate QOL. Pre- and post-sleep medication values of questionnaires were compared. Results Among 20 enrolled patients, 16 completed the study protocol. Zolpidem, eszopiclone, and suvorexant were administered to six, nine, and one patient, respectively. Each median total score of questionnaires (pre-/post-sleep medication, respectively) was as follows: PSQI, 10.0/8.5; ESS, 12.5/5.0; AIS, 10.0/4.0; mFSSG, 21.0/16.0; GSRS, 44.0/31.0 (Pain in GSRS, 11.0/5.0); JPAC-QOL, 26.0/15.5; SF-36, 63.9/71.9. All of these results showed statistically significant differences between pre- and post-sleep medication (p < 0.05). Conclusions Improvement of sleep disturbance by administration of sleep aids resulted in improvement of GI symptoms and QOL in patients with FD. This effect may be related to pain modification.

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Self-reported Sleep Impairment in Functional Dyspepsia and Irritable Bowel Syndrome

Cited by 36 publications

References 45 publications

Sex-Gender Differences in Irritable Bowel Syndrome

Sex-Gender Differences in Irritable Bowel Syndrome

Sleep disorders in patients with functional dyspepsia: A multicenter study from the Korean Society of Neurogastroenterology and Motility

Impact of improvement of sleep disturbance on symptoms and quality of life in patients with functional dyspepsia

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