Self-reported sleep disturbances in HIV-infected people: a meta-analysis of prevalence and moderators

Wu, Jie; Wu, Hong; Lu, Ciyong; Guo, Lan; Li, Pengsheng

doi:10.1016/j.sleep.2015.03.027

Cited by 92 publications

(85 citation statements)

References 60 publications

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“…Findings from a recent meta-analysis of 27 studies revealed a pooled prevalence of 58%, 1 which is considerably higher than the average prevalence of insomnia symptoms (10–33% based on variations in symptom assessment) and diagnoses (6%) in the general population. 2 Among those living with HIV, sleep disturbances and poor sleep quality are highly prevalent quality of life issues.…”

Section: Introductionmentioning

confidence: 89%

Engagement in care, psychological distress, and resilience are associated with sleep quality among HIV-positive gay, bisexual, and other men who have sex with men

et al. 2016

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Objectives We investigated risk and protective factors associated with sleep quality among a national sample of HIV-positive gay, bisexual, and other men who have sex with men (GBMSM). Design This study reports on findings from both an eligibility survey and baseline assessment for an online HIV risk reduction intervention. Participants There were 16,466 completed eligibility surveys. A total of 1,205 eligible men completed a baseline assessment after consenting to participate in the intervention. Measurements and results Among participants with a completed eligibility survey, men with an HIV-positive status had significantly worse sleep quality and more frequent use of sleep medications during the past month than HIV-negative men. Within the intervention sample (n = 1,205 HIV-positive participants), men with symptoms of anxiety (Adjusted odds ratio [AOR]=2.80; 95% confidence interval [CI]: 1.93–4.06) and depression (AOR=1.66; CI: 1.14–2.43), and who reported a detectable viral load in the past six months (AOR=1.57; CI: 1.06–2.33) had increased odds of poor sleep quality after controlling for demographic characteristics, socioeconomic status, ART use and adherence, substance use, and CD4 count. However, men with greater perceived resilience had decreased odds of reporting poor sleep quality during the past month (AOR=0.68; CI: 0.51–0.89). Conclusions Findings from this online study call for more attention to the role of sleep in immune system functioning and engagement in HIV care. Results further suggest a need to design and test culturally-appropriate sleep health interventions for GBMSM living with HIV that promote protective factors and target particular behavioral changes (i.e., stress reduction, substance use).

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Section: Introductionmentioning

confidence: 89%

Engagement in care, psychological distress, and resilience are associated with sleep quality among HIV-positive gay, bisexual, and other men who have sex with men

et al. 2016

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“…27,28 Sleep disturbances are common in PLWH, affecting between 30–100% of PLWH, 28 and can manifest in a lack of or poor quality of sleep. 5,28,29 Inability to sleep results from physiological factors including the affect of HIV on the central nervous system, 28 medication side effects (e.g. vivid dreams, neuropathy), 15,29 effects of stimulant intake (e.g.…”

Section: Fatigue In People Living With Hivmentioning

confidence: 99%

“…5,28,29 Inability to sleep results from physiological factors including the affect of HIV on the central nervous system, 28 medication side effects (e.g. vivid dreams, neuropathy), 15,29 effects of stimulant intake (e.g. nicotine, caffeine, amphetamines), 28,29 or from psychological factors that impede restful sleep (e.g.…”

Section: Fatigue In People Living With Hivmentioning

confidence: 99%

“…vivid dreams, neuropathy), 15,29 effects of stimulant intake (e.g. nicotine, caffeine, amphetamines), 28,29 or from psychological factors that impede restful sleep (e.g. anxiety and stress).…”

Section: Fatigue In People Living With Hivmentioning

confidence: 99%

“…17,30 In addition to inability to sleep, the aforementioned factors can diminish the quality of sleep resulting experiences of physical and mental fatigue, depression, and excessive daytime sleepiness. 5,28,29 Finally, PLWH may turn to the use of substances or caffeine intake to help them sleep or to cope with fatigue or psychological symptoms, 2 but studies have found that such actions often exacerbate sleep disturbances thus perpetuating fatigue rather than eliminating it.…”

Section: Fatigue In People Living With Hivmentioning

confidence: 99%

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Fatigue Symptom Management in People Living With Human Immunodeficiency Virus

Perazzo

Webel

Voss

et al. 2017

J Hosp Palliat Nurs

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Fatigue is a subjective, unpleasant, potentially disabling symptom rooted in physiological, psychological, and behavioral causes. People living with HIV are a population highly affected by fatigue due to risk factors associated with HIV-infection, treatment, and psychosocial disease burden. People with HIV are living longer, and are facing the challenge of a longer disease trajectory. Palliative nurses with expertise in symptom management can play a crucial role in helping people with HIV to engage in health behaviors that prevent or mitigate fatigue. In this paper we present a definition and overview of fatigue, describe the problem of fatigue in people living with HIV, and present a case study that illustrates the role of the palliative nurse in helping a person with HIV to cope with fatigue.

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Overnight urinary melatonin levels in women with and without HIV: An observational cohort study

Burgess,

Weber,

Morack

et al. 2023

Brain and Behavior

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IntroductionDespite significant improvements in longevity and quality of life associated with antiretroviral therapy, individuals with HIV still suffer from a higher burden of sleep and circadian disruption and inflammatory‐based diseases than individuals without HIV. While melatonin is a hormone that has a role in sleep and circadian regulation and has anti‐inflammatory properties, the overnight concentration of the urinary melatonin metabolite has not yet been reported in people with HIV.MethodsThe aim of this study was to compare the overnight urinary melatonin metabolite levels in women aged 35–70 years with HIV (n = 151) to a well‐matched comparison group of women without HIV (n = 147). All women wore a wrist actigraphy monitor and completed daily diaries documenting sleep timing and use of medications and drugs or alcohol for 10 days. Participants collected their overnight urine near the end of the monitoring period.ResultsMelatonin levels did not differ between women with or without HIV, but more than 40% of women had low levels of melatonin. Higher body mass index predicted lower levels of melatonin, and lower levels of melatonin were associated with lower sleep efficiency as assessed with wrist actigraphy.ConclusionThese data lay the foundation for exploration of the longitudinal consequences of endogenous melatonin levels for inflammatory‐based diseases in aging women with and without HIV. Future studies should consider the use of supplemental melatonin to improve sleep in women with lower levels of melatonin.

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Self-reported sleep disturbances in HIV-infected people: a meta-analysis of prevalence and moderators

Cited by 92 publications

References 60 publications

Engagement in care, psychological distress, and resilience are associated with sleep quality among HIV-positive gay, bisexual, and other men who have sex with men

Engagement in care, psychological distress, and resilience are associated with sleep quality among HIV-positive gay, bisexual, and other men who have sex with men

Fatigue Symptom Management in People Living With Human Immunodeficiency Virus

Overnight urinary melatonin levels in women with and without HIV: An observational cohort study

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