Self-reported sleep disturbance and incidence of dementia in ageing men

Luojus, Maria K.; Lehto, Soili M.; Tolmunen, Tommi; Brem, Anna‐Katharine; Lönnroos, Eija; Kauhanen, Jussi

doi:10.1136/jech-2016-207764

Cited by 26 publications

(28 citation statements)

References 52 publications

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“…They also had a higher prevalence of anxiety, euphoria, disinhibition, and aberrant motor behaviour. Another study found that sleep disturbances during middle age are associated with the development of dementia in later life . Cognitive impairment is reportedly increased in older women with sleep‐disordered breathing …”

Section: Sleep and Dementiamentioning

confidence: 99%

“…Another study found that sleep disturbances during middle age are associated with the development of dementia in later life. 112 Cognitive impairment is reportedly increased in older women with sleep-disordered breathing. 113 In recent years there has been substantial progress in the detection and recognition of dementia with Lewy bodies (DLB), which has emerged as a common and important clinical disorder.…”

Section: Sleep and Dementiamentioning

confidence: 99%

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Sleep disorders in the elderly: a growing challenge

2018

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In contrast to newborns, who spend 16-20 h in sleep each day, adults need only about sleep daily. However, many elderly may struggle to obtain those 8 h in one block. In addition to changes in sleep duration, sleep patterns change as age progresses. Like the physical changes that occur during old age, an alteration in sleep pattern is also a part of the normal ageing process. As people age, they tend to have a harder time falling asleep and more trouble staying asleep. Older people spend more time in the lighter stages of sleep than in deep sleep. As the circadian mechanism in older people becomes less efficient, their sleep schedule is shifted forward. Even when they manage to obtain 7 or 8 h sleep, they wake up early, as they have gone to sleep quite early. The prevalence of sleep disorders is higher among older adults. Loud snoring, which is more common in the elderly, can be a symptom of obstructive sleep apnoea, which puts a person at risk for cardiovascular diseases, headaches, memory loss, and depression. Restless legs syndrome and periodic limb movement disorder that disrupt sleep are more prevalent in older persons. Other common medical problems of old age such as hypertension diabetes mellitus, renal failure, respiratory diseases such as asthma, immune disorders, gastroesophageal reflux disease, physical disability, dementia, pain, depression, and anxiety are all associated with sleep disturbances.

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Section: Sleep and Dementiamentioning

confidence: 99%

Section: Sleep and Dementiamentioning

confidence: 99%

Sleep disorders in the elderly: a growing challenge

2018

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“…Interestingly, a recent longitudinal study in aging men found that sleep disturbances, but not daytime tiredness or sleep duration, were associated with a 58% increase in dementia after adjusting for known metabolic and inflammatory risk factors (e.g. C-reactive protein), and physical activity (Luojus et al, 2017). As discussed earlier, NCD-related neuropathology itself disrupts brain circuits and structures that are critical for normative sleep regulation, such as the ascending arousal system (Holth et al, 2017).…”

Section: Discussionmentioning

confidence: 94%

Self-reported sleep disturbances are associated with poorer cognitive performance in older adults with hypertension: a multi-parameter risk factor investigation

Kohn

Troyer

Guay-Ross

et al. 2019

Int. Psychogeriatr.

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Objectives:Given the evidence of multi-parameter risk factors in shaping cognitive outcomes in aging, including sleep, inflammation, cardiometabolism, and mood disorders, multidimensional investigations of their impact on cognition are warranted. We sought to determine the extent to which self-reported sleep disturbances, metabolic syndrome (MetS) factors, cellular inflammation, depressive symptomatology, and diminished physical mobility were associated with cognitive impairment and poorer cognitive performance.Design:This is a cross-sectional study.Setting:Participants with elevated, well-controlled blood pressure were recruited from the local community for a Tai Chi and healthy-aging intervention study.Participants:One hundred forty-five older adults (72.7 ± 7.9 years old; 66% female), 54 (37%) with evidence of cognitive impairment (CI) based on Montreal Cognitive Assessment (MoCA) score ≤24, underwent medical, psychological, and mood assessments.Measurements:CI and cognitive domain performance were assessed using the MoCA. Univariate correlations were computed to determine relationships between risk factors and cognitive outcomes. Bootstrapped logistic regression was used to determine significant predictors of CI risk and linear regression to explore cognitive domains affected by risk factors.Results:The CI group were slower on the mobility task, satisfied more MetS criteria, and reported poorer sleep than normocognitive individuals (all p < 0.05). Multivariate logistic regression indicated that sleep disturbances, but no other risk factors, predicted increased risk of evidence of CI (OR = 2.00, 95% CI: 1.26–4.87, 99% CI: 1.08–7.48). Further examination of MoCA cognitive subdomains revealed that sleep disturbances predicted poorer executive function (β = –0.26, 95% CI: –0.51 to –0.06, 99% CI: –0.61 to –0.02), with lesser effects on visuospatial performance (β = –0.20, 95% CI: –0.35 to –0.02, 99% CI: –0.39 to 0.03), and memory (β = –0.29, 95% CI: –0.66 to –0.01, 99% CI: –0.76 to 0.08).Conclusions:Our results indicate that the deleterious impact of self-reported sleep disturbances on cognitive performance was prominent over other risk factors and illustrate the importance of clinician evaluation of sleep in patients with or at risk of diminished cognitive performance. Future, longitudinal studies implementing a comprehensive neuropsychological battery and objective sleep measurement are warranted to further explore these associations.

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“…En caso de haberse controlado vía diseño, en el apartado de método se debe explicar claramente si la técnica de control ha sido por emparejamiento entre expuestos y no expuestos y cómo se ha realizado este, si se ha estratificado a priori por la variable a controlar, etc. Cabe comentar la importancia del uso de técnicas de análisis multivariante en el análisis de las variables de confusión y como técnica específica para este tipo de estudios, el análisis de supervivencia a partir de los modelos de regresión de Cox (Choi, Shin, Cho y Park, 2017;Luojus et al, 2017;Ngamini Ngui et al, 2013;Niemi, Suvisaari, Haukka, Wrede y Lönnqvist, 2004;Strik, Lousberg, Cheriex y Honig, 2004;Strober, Freeman y Morrell, 1997…”

Section: Estudios De Cohortesunclassified

Guía de cómo reportar un estudio epidemiológico observacional en salud: elementos imprescindibles

Peró‐Cebollero

2017

Anuario de Psicología

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Directrices; Estudios epidemiológicos; Estudios caso-control; Estudios de cohortes Resumen En el presente documento se proporciona una breve guía sobre qué aspectos son relevantes para la planificación de un estudio epidemiológico observacional y, en consecuencia, cuál es la información básica que se debe tener en cuenta para reportar este tipo de estudios. Así pues, se hace una diferenciación entre casos prevalentes y casos incidentes, así como una diferenciación entre estudios descriptivos y estudios relacionales. Los primeros básicamente se utilizan para determinar el estado de salud de la población, en tanto que los segundos se focalizan en el estudio de la etiología del trastorno bajo estudio. En los estudios relacionales, se diferencia entre estudios transversales, de cohortes y caso-control, y para cada uno de ellos se especifican los elementos básicos a tener en cuenta, como por ejemplo, la definición del periodo de observación y, en consecuencia, el tiempo en riesgo, la determinación del estatus de trastorno, el de exposición y otros factores a tener en cuenta. En este último punto se hace especial referencia a la importancia de la fiabilidad y la validez de los instrumentos de medida utilizados para determinar este estatus y, en especial, a medidas propias del ámbito más epidemiológico como es la sensibilidad y la especificidad, así como los valores predictivos.

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Self-reported sleep disturbance and incidence of dementia in ageing men

Abstract: Self-reported frequent sleep disturbance in middle-aged men may relate to the development of dementia in later life. Having an ε4 genotype did not affect the relationship.

Cited by 26 publications

References 52 publications

Sleep disorders in the elderly: a growing challenge

Sleep disorders in the elderly: a growing challenge

Self-reported sleep disturbances are associated with poorer cognitive performance in older adults with hypertension: a multi-parameter risk factor investigation

Guía de cómo reportar un estudio epidemiológico observacional en salud: elementos imprescindibles

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