Self-reported Sleep and β-Amyloid Deposition in Community-Dwelling Older Adults

Spira, Adam P.; Gamaldo, Alyssa A.; An, Yang; Wu, Mark N.; Simonsick, Eleanor M.; Bilgel, Murat; Zhou, Yun; Wong, Dean F.; Ferrucci, Luigi; Resnick, Susan M.

doi:10.1001/jamaneurol.2013.4258

Cited by 383 publications

(456 citation statements)

References 43 publications

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“…PET studies of the link between β‐amyloid deposition and self‐reported sleep in older adults have shown, after adjustment for potential confounders, that a shorter sleep duration is associated with greater Aβ burden in cortical areas and the precuneus. Lower sleep quality was associated with greater Aβ burden in the precuneus (Spira et al, 2013). Importantly, Aβ overlaps DMN regions in which hypometabolism and atrophy were detected in AD patients (Buckner et al, 2005).…”

Section: Melatonin In the Treatment Of Circadian Rhythm And Sleep Dismentioning

confidence: 99%

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Zisapel

2018

British J Pharmacology

550

350

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In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light–dark cycle to invigorate and optimize the internal temporal order. The SCN‐activated, light‐inhibited production of melatonin conveys the message of darkness to the clock and induces night‐state physiological functions, for example, sleep/wake blood pressure and metabolism. Clinically meaningful effects of melatonin treatment have been demonstrated in placebo‐controlled trials in humans, particularly in disorders associated with diminished or misaligned melatonin rhythms, for example, circadian rhythm‐related sleep disorders, jet lag and shift work, insomnia in children with neurodevelopmental disorders, poor (non‐restorative) sleep quality, non‐dipping nocturnal blood pressure (nocturnal hypertension) and Alzheimer's disease (AD). The diminished production of melatonin at the very early stages of AD, the role of melatonin in the restorative value of sleep (perceived sleep quality) and its sleep‐anticipating effects resulting in attenuated activation of certain brain networks are gaining a new perspective as the role of poor sleep quality in the build‐up of β amyloid, particularly in the precuneus, is unravelled. As a result of the recently discovered relationship between circadian clock, sleep and neurodegeneration, new prospects of using melatonin for early intervention, to promote healthy physical and mental ageing, are of prime interest in view of the emerging link to the aetiology of Alzheimer's disease.Linked ArticlesThis article is part of a themed section on Recent Developments in Research of Melatonin and its Potential Therapeutic Applications. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.16/issuetoc

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Section: Melatonin In the Treatment Of Circadian Rhythm And Sleep Dismentioning

confidence: 99%

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Zisapel

2018

British J Pharmacology

550

350

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“…A cross-sectional study conducted by Spira et al studied 70 community-dwelling subjects using self-report sleep measures and [11C]-Pittsburgh compound B positron emission tomography (PiB PET) amyloid imaging [29]. They found a greater Aβ burden associated with both self-reported shorter sleep duration and poorer sleep quality [29].…”

Section: Associations Between Sleep Disruption and Admentioning

confidence: 99%

“…They found a greater Aβ burden associated with both self-reported shorter sleep duration and poorer sleep quality [29]. Mander et al [30] also used PiB PET to image brain Aβ deposits in 98 older adults.…”

Section: Associations Between Sleep Disruption and Admentioning

confidence: 99%

“…In humans, a study showed that CSF Aβ concentration decreases following a night of sleep, while after sleep deprivation, this concentration was shown to increase [57]. Additionally, Aβ burden was found to be greater in community-based older adults with self-reported inadequate quantity and quality in sleep [29].…”

Section: Sleep Disturbances and Aβ Aggregation The Default Mode Netwmentioning

confidence: 99%

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Is Sleep Disruption a Risk Factor for Alzheimer’s Disease?

Macedo

Balouch

Tabet

2017

JAD

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Sleep disturbances are routinely encountered in Alzheimer's disease (AD) and affect about 25-40% of patients in the mild-to-moderate stages of the disease. In many, sleep pathology may represent a symptom of the underlying neurodegeneration. However, a history of sleep disruption occurring years prior to onset of cognitive symptoms could represent a potential risk factor for AD. The aim of the present narrative review was to evaluate current evidence linking sleep disturbances with AD development and to understand the mechanisms that may contribute to this.Although the mechanisms by which poor sleep may contribute to AD genesis is not fully understood, emerging evidence linking disturbances in the sleep wake cycle with Aβ deposition is shedding light on the relationship between sleep pathology and the subsequent development of AD. Aβ burden appears to be enhanced by sleep-wake cycle disruptions and is suspected as being an important mechanism by which sleep disruptions contribute in AD development. Other mechanisms triggered by sleep disruption may also be involved in AD development, such as brain hypoxia, oxidative stress, circadian activity rhythms disturbances, overexpression of orexins and blood brain barrier impairment. Further understanding of the link between sleep disturbances and future development of AD is still needed before sleep disturbances are clearly marked as a preventable risk factor for AD. In these circumstances, early lifestyle interventions to help increase the quantity and quality of sleep may have a favorable outcome on decreasing the incidence of AD and this needs to be investigated further.

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“…Already in 1924, it was discovered that people who sleep longer remember more. Poor sleep and deficiency is associated with a higher level of substance that causes Alzheimer's disease [18] (Figure 1). …”

Section: Introductionmentioning

confidence: 99%

Disturbances of Sleep Among Older People and its Influence on Cognitive Performance

RóÅ1⁄4yk-Myrta¹,

Brodziak²,

KoÅat³

et al. 2017

J Gerontol Geriatr Res

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Sleep disorders are common in the general population. People suffering from a variety of general, neurological, and mental disorders are in high risk group. Insomnia, which is the most often form of sleep disorder, can be the onset of depression. Symptoms accompanying various neurological disorders are often a consequence of underlying sleep disorders.Objective: Examining the correlation between sleep disorders and the reduction of cognitive abilities among older people. Methods:We gathered data from 56 respondents from the University of the Third Age, aged between 52 and 81. We also performed certain objective measurements, using Montreal Cognitive Assessment (MOCA), a test of working memory system and the measurements of "visuomotor" coordination.Results: Correlation has been found between the results from the proposed sleep quality scale and the outcome of MOCA as well as other measurements.

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Self-reported Sleep and β-Amyloid Deposition in Community-Dwelling Older Adults

Cited by 383 publications

References 43 publications

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Is Sleep Disruption a Risk Factor for Alzheimer’s Disease?

Disturbances of Sleep Among Older People and its Influence on Cognitive Performance

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