Self-reported recreational exercise combining regularity and impact is necessary to maximize bone mineral density in young adult women

Callréus, Mattias; McGuigan, Fiona; Ringsberg, Karin; Åkesson, Kristina

doi:10.1007/s00198-011-1886-5

Cited by 24 publications

(23 citation statements)

References 50 publications

(41 reference statements)

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“…Calibrations were performed daily using a manufacturer supplied phantom. The precision error (coefficient of variation) was 0.94%, 1.45%, 4.01% for total body, lumbar spine and femoral neck, respectively in the OPRA cohort [34], and 0.90% and 0.65% for femoral neck and lumbar spine, respectively in the PEAK--25 cohort [35]. Bone loss was calculated in the OPRA cohort as BMD at 5 year follow--up minus BMD at baseline.…”

Section: Subjectsmentioning

confidence: 99%

Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly

Herlin

McGuigan

Luthman

et al. 2015

Bone

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Section: Subjectsmentioning

confidence: 99%

Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly

Herlin

McGuigan

Luthman

et al. 2015

Bone

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“…The present training protocol would be comparable to recreational training in humans, which has been found to have positive effects on areal BMD (Callreus et al 2012). The results of this study highlight the structural changes in bone with a running protocol.…”

Section: Discussionmentioning

confidence: 52%

Skeletal site-specific effects of endurance running on structure and strength of tibia, lumbar vertebrae, and mandible in male Sprague–Dawley rats

Bott

Sacco

Turnbull

et al. 2016

Appl. Physiol. Nutr. Metab.

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Bone microarchitecture, bone mineral density (BMD), and bone strength are affected positively by impact activities such as running; however, there are discrepancies in the magnitude of these effects. These inconsistencies are mainly a result of varying training protocols, analysis techniques, and whether or not the skeletal sites measured are weight bearing. This study's purpose was to determine the effects of endurance running on sites that experience different weight bearing and load. Eight-week-old male Sprague-Dawley rats (n = 20) were randomly assigned to either a group with a progressive treadmill running protocol (25 m/min for 1 h, incline of 10%) or a nontrained control group for 8 weeks. The trabecular structure of the tibia, lumbar vertebra (L3), and mandible and the cortical structure at the tibia midpoint were measured using microcomputed tomography to quantify bone volume fraction (i.e., bone volume divided by total volume (BV/TV)), trabecular number (Tb.N), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), and cortical thickness. BMD at the proximal tibia, lumbar vertebrae (L1-L3), and mandible was measured using dual energy X-ray absorptiometry. The tibia midpoint strength was measured by 3-point bending using a materials testing system. Endurance running resulted in superior bone structure at the proximal tibia (12% greater BV/TV (p = 0.03), 14% greater Tb.N (p = 0.01), and 19% lower Tb.Sp (p = 0.05)) but not at other sites. Contrary to our hypothesis, mandible bone structure was altered after endurance training (8% lower BV/TV (p < 0.01) and 15% lower Tb.Th (p < 0.01)), which may be explained by a lower food intake, resulting in less mechanical loading from chewing. These results highlight the site-specific effects of loading on the skeleton.

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“…Springer Callreus et al2013-02-12 15:04 6 (21) The precision of DXA measurements in our hands has previously been determined as 0.90% in the femoral neck and 0.65% in the lumbar spine [21].…”

Section: Bone Mass and Body Compositionmentioning

confidence: 75%

Birth weight is more important for peak bone mineral content than for bone density: the PEAK-25 study of 1,061 young adult women

2012

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Birth weight is more important for peak bone mineral content than for bone density: the PEAK-25 study of 1,061 young adult women. Link to publication Citation for published version (APA): Callréus, M., McGuigan, F., & Åkesson, K. (2013). Birth weight is more important for peak bone mineral content than for bone density: the PEAK-25 study of 1,061 young adult women. Osteoporosis International, 24(4), 1347 -1355 . DOI: 10.1007 /s00198-012-2077 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ABSTRACTPurpose: The aim of this study was to evaluate the influence of birth weight on peak bone mass and body composition in a cohort of 25-year-old women.Methods: 1061 women participated in this cross-sectional population-based study, using dual energy X-ray absorptiometry (DXA) to assess BMC, BMD and body composition (total body (TB), femoral neck (FN), total hip (TH), lumbar spine L1-L4 (LS), lean and fat mass). Birth weight data was available for 1047 women and was categorized into tertiles of low (≤3180 g 2.5kg total body lean mass). The strongest correlations between birth weight and BMC occurred in women with the lowest birth weights, although excluding women who weighed <2500 g at birth, the correlation remained significant although slightly weaker.Conclusions: Women with lower birth weight have lower bone mineral content, independent of current body weight, and less lean and fat mass at the age of 25. Lower birth weight has a greater negative influence on bone mass than the positive influence of higher birth weight.

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Self-reported recreational exercise combining regularity and impact is necessary to maximize bone mineral density in young adult women

Cited by 24 publications

References 50 publications

Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly

Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly

Skeletal site-specific effects of endurance running on structure and strength of tibia, lumbar vertebrae, and mandible in male Sprague–Dawley rats

Birth weight is more important for peak bone mineral content than for bone density: the PEAK-25 study of 1,061 young adult women

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