Self-reported quality of life of patients with multiple sclerosis with mild disability

Effat, S.; Azzam, Hanan; Shalash, Ali; Elkatan, Seham; Elrassas, Hanan

doi:10.4103/1110-1083.192659

Cited by 5 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, we found that duration of MS failed to affect depression level and perceived social support in patients. On the other hand, those participants with increase relapse rate experienced higher depression levels which is similar to findings reported by Effat …”

Section: Discussionsupporting

confidence: 89%

“…Correspondingly, Effat evaluated the quality of life (QoL) of patients with relapsing remitting multiple sclerosis (RRMS) who are ambulatory and slightly disabled, and he also explored the associated factors and cultural characteristics. The participants were 60 Egyptian patients with a definitive diagnosis of RRMS and they were assessed for disability using Expanded Disability Status Scale, their QoL using Multiple Sclerosis Quality of Life Inventory (MSQLI), and depression using the Beck Depression Inventory scale.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Depression and perceived social support among Saudi patients with multiple sclerosis

Hyarat

Al-Gamal

2018

Perspect Psychiatr Care

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Depression and perceived social support among Saudi patients with multiple sclerosis

Hyarat

Al-Gamal

2018

Perspect Psychiatr Care

View full text Add to dashboard Cite

show abstract

“…It can be primary or secondary to sleep disturbances, depression, or the use of immunomodulating therapies (Catalan et al 2011 ). Fatigue was negatively correlated with disease duration and with cognitive impairment (Effata et al 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Serum insulin-like growth factor 1 (IGF-1) in multiple sclerosis: relation to cognitive impairment and fatigue

Nageeb

Hashim

Fawzy

2018

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

BackgroundMultiple sclerosis (MS) is a chronic demyelinating central nervous system (CNS) disease. Changes in insulin growth factor 1 (IGF-1) input to the brain can affect survival of myelin and CNS cells. The study aims to investigate the relation of serum IGF-1 levels with cognitive impairment and fatigue in MS patients.MethodsThis study was conducted on 46 MS patients and 46 healthy controls. All participants were subjected to clinical assessment, serum IGF-1 levels, expanded disability status scale (EDSS), modified fatigue impact scale (MFIS), and Montreal cognitive assessment (MoCA) scale.ResultsThere was no significant difference between patients and controls regarding serum IGF-1 levels (P = 0.19). However, low serum levels of IGF-1 have significantly greater odds for fatigue (P = 0.002) and cognitive impairment (P < 0.001). Also, serum IGF-1 levels have a significant negative correlation with MFIS (r = − 0.701 and P < 0.001) and a significant positive correlation with MoCA scale (r = + 0.84 and P < 0.001).ConclusionsThe results, specifically that low levels of serum IGF-1 was associated with cognitive impairment and fatigue in MS, suggest that IGF-I may be involved in the pathogenesis of cognitive deficits and fatigue in MS disease.

show abstract

“…20 Depression is a common manifestation in patients with MS and significantly impairs their QoL. 24,25 In the current study, RRMS patients with tremors showed worse depressive scores, but there was no correlation to tremor severity. To our knowledge, no previous studies have investigated the association between tremors and depression in patients with MS, indicating the need for more studies to confirm this association.…”

Section: Discussionmentioning

confidence: 49%

Tremor in Patients with Relapsing‐Remitting Multiple Sclerosis: Clinical Characteristics and Impact on Quality of Life

Shalash,

Elhodeby,

Saad

et al. 2023

Movement Disord Clin Pract

View full text Add to dashboard Cite

Background Little is known about the prevalence and clinical characteristics of tremors in patients with multiple sclerosis (MS), their associated clinical disability, and their impact on quality of life (QoL). Objective This study aimed to investigate the frequency and types of tremors in patients with relapsing remitting MS (RRMS) in remission, and their impact on patients’ QoL. Methods A total of 250 patients with RRMS in remission were examined for tremors. All patients were assessed using the Expanded Disability Status Scale (EDSS). Patients with tremors underwent further assessment using the Fahn‐Tolosa‐Marin Tremor Rating Scale (FTMTRS), the Beck Depression Inventory (BDI), the Montreal Cognitive Assessment (MoCA) scale, and the Short Form 36 Health Survey Questionnaire (SF‐36). Brain MRI was obtained for a subgroup of patients. Results Tremors were detected in 36 patients (14.4%) and were associated with significantly worse EDSS scores, BDI (P = 0.021), MoCA, most SF‐36 domains, higher total and last year relapses (P < 0.001) and longer disease duration (P = 0.027). Patients with tremors showed higher lesion load (P = 0.007), more infratentorial (P ≤ 0.001), cerebellar and diencephalic lesions (P = 0.024), and cortical atrophy (P = 0.012). Total FTMTRS was significantly correlated to age, EDSS, and physical functioning. Dystonia was associated with tremors in 17 patients (6.8% of total RRMS patients and 47.2% of patients with tremors). Conclusion The current study confirms the common occurrence of tremors and their subtypes among patients with RRMS with mild disability and demonstrates their association with increased disability and impaired QoL.

show abstract

Self-reported quality of life of patients with multiple sclerosis with mild disability

Cited by 5 publications

References 0 publications

Depression and perceived social support among Saudi patients with multiple sclerosis

Depression and perceived social support among Saudi patients with multiple sclerosis

Serum insulin-like growth factor 1 (IGF-1) in multiple sclerosis: relation to cognitive impairment and fatigue

Tremor in Patients with Relapsing‐Remitting Multiple Sclerosis: Clinical Characteristics and Impact on Quality of Life

Contact Info

Product

Resources

About