Self-Reported Pain in Male and Female Iraq/Afghanistan-Era Veterans: Associations with Psychiatric Symptoms and Functioning

Naylor, Jennifer C.; Wagner, H. Ryan; Brancu, Mira; Shepherd‐Banigan, Megan; Elbogen, Eric B.; Kelley, Michelle L.; Fecteau, Teresa E; Goldstein, Kenneth M.; Kimbrel, Nathan A.; Marx, Christine E.; Strauss, Jennifer

doi:10.1093/pm/pnw308

Cited by 9 publications

(15 citation statements)

References 41 publications

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“…Significant correlation was not detected between clinical pain intensity ratings and slow-5 power (Correlation (r): − 0.04 to 0.23). While a trend towards higher (relative to the low pain FOP group) power in the slow-4 sub-band (Channel C10) for the high pain FOP cohort was observed, a significant intergroup difference was not present (p = 0.137) pain conditions in women [31,47]. Additionally, slightly higher pain levels were measured in older FOP patients relative to younger patients; an observation that was previously observed in other rare musculoskeletal conditions [21].…”

Section: Discussionsupporting

confidence: 51%

Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva

Peng

Karunakaran

Labadie

et al. 2021

Orphanet J Rare Dis

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Background Pain is a highly prevalent symptom experienced by patients across numerous rare musculoskeletal conditions. Much remains unknown regarding the central, neurobiological processes associated with clinical pain in musculoskeletal disease states. Fibrodysplasia ossificans progressiva (FOP) is an inherited condition characterized by substantial physical disability and pain. FOP arises from mutations of the bone morphogenetic protein (BMP) receptor Activin A receptor type 1 (ACVR1) causing patients to undergo painful flare-ups as well as heterotopic ossification (HO) of skeletal muscles, tendons, ligaments, and fascia. To date, the neurobiological processes that underlie pain in FOP have rarely been investigated. We examined pain and central pain mechanism in FOP as a model primary musculoskeletal condition. Central nervous system (CNS) functional properties were investigated in FOP patients (N = 17) stratified into low (0–3; 0–10 Scale) and high (≥ 4) pain cohorts using functional near-infrared spectroscopy (fNIRS). Associations among clinical pain, mental health, and physical health were also quantified using responses derived from a battery of clinical questionnaires. Results Resting-state fNIRS revealed suppressed power of hemodynamic activity within the slow-5 frequency sub-band (0.01–0.027 Hz) in the prefrontal cortex in high pain FOP patients, where reduced power of slow-5, prefrontal cortex oscillations exhibited robust negative correlations with pain levels. Higher clinical pain intensities were also associated with higher magnitudes of depressive symptoms. Conclusions Our findings not only demonstrate a robust coupling among prefrontal cortex functionality and clinical pain in FOP but lays the groundwork for utilizing fNIRS to objectively monitor and central pain mechanisms in FOP and other musculoskeletal disorders.

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Section: Discussionsupporting

confidence: 51%

Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva

Peng

Karunakaran

Labadie

et al. 2021

Orphanet J Rare Dis

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“…The definite mechanism underpinning the association between female sex and higher prevalence of the musculoskeletal pain remains poorly understood. The sex‐specific association with pain may be related to the willingness to disclose since women report more pain than men [34]. Moreover, laboratory research did not produce a robust evidence for the sex differences in human pain sensitivity of healthy individuals [35].…”

Section: Discussionmentioning

confidence: 96%

Prevalence and Risk Factors for Musculoskeletal Pain in Keyboard Musicians: A Systematic Review

Corrêa

Santos

Paranhos

et al. 2018

PM&R

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“…mental health study of 3,000 Operation Enduring Freedom and Operation Iraqi Freedom veterans, women reported significantly higher intensity from headache, pain, and muscle soreness (Naylor et al, 2017). Gradus et al (2017) found that women who received a diagnosis of post-traumatic stress disorder (PTSD) and had a history of alcohol abuse or dependence were more likely than men to engage in nonfatal intentional self-harm.…”

mentioning

confidence: 99%

Health Status of Female and Male Gulf War and Gulf Era Veterans: A Population-Based Study

Dursa

Barth

Porter

et al. 2019

Women's Health Issues

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Background: The health of women Gulf War (deployed) and Gulf Era (nondeployed) veterans is understudied; although most studies examining the health effects of deployment to the Gulf War adjust for gender in multivariate analyses, gender-specific prevalence and effect measures are not routinely reported. The National Academy of Medicine recommended that the Department of Veterans Affairs assess gender-specific health conditions in large cohort studies of Gulf War veterans. Methods: Data from this study come from the follow-up study of a national cohort of Gulf War and Gulf Era veterans. This study was conducted between 2012 and 2014, and was the second follow-up of a population-based cohort of Gulf War and Gulf Era veterans that began in 1995. Measures included self-reported medical conditions and frequency of doctor visits as well as validated screening instruments for mental health conditions. Results: Overall, female veterans (both Gulf War and Era) reported poorer health than their male counterparts as measured by the prevalence of self-reported disease. The top five prevalent conditions in both Gulf War and Gulf Era veterans were migraine, hypertension, major depressive disorder, arthritis, and dermatitis. Female Gulf War veterans were found to have a higher prevalence of disease than male Gulf Era veterans. Conclusions: Women veterans, particularly deployed veterans, from this era have significant medical needs that may justify increased outreach from the Department of Veterans Affairs. Our findings highlight the importance of asking about military service, particularly for women veterans, in the clinical setting, both in the Department of Veterans Affairs and in the private sector. Published by Elsevier Inc. on behalf of Jacobs Institute of Women's Health.

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Self-Reported Pain in Male and Female Iraq/Afghanistan-Era Veterans: Associations with Psychiatric Symptoms and Functioning

Cited by 9 publications

References 41 publications

Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva

Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva

Prevalence and Risk Factors for Musculoskeletal Pain in Keyboard Musicians: A Systematic Review

Health Status of Female and Male Gulf War and Gulf Era Veterans: A Population-Based Study

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