Self-reported Musculoskeletal Symptoms Among Danish Women With Cosmetic Breast Implants

Kjøller, Kim; Hölmich, Lisbet Rosenkrantz; Fryzek, Jon P.; Jacobsen, Poul Harboe; Friis, Søren; McLaughlin, Joseph K.; Lipworth, Loren; Henriksen, Trine; Høier‐Madsen, Mimi; Wiik, Allan; Olsen, Jørgen H.

doi:10.1097/01.sap.0000101930.75241.55

Cited by 8 publications

(5 citation statements)

References 47 publications

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“…Gland Surg In contrast, the risk of Raynaud's phenomenon was not increased in five other smaller studies (10,12,(29)(30)(31).…”

Section: Ssc and Raynaud's Phenomenonmentioning

confidence: 85%

“…Two studies reported a 1.8 to 2.3-fold increase in risk of morning or joint stiffness among women with breast implants compared to women with other cosmetic surgeries or from the general population (15,29). Joint swelling was not more frequently reported (12,(27)(28)(29)31).…”

Section: Ra and Joint-related Symptomsmentioning

confidence: 98%

“…cn/static/public/gs-21-266-2.pdf). The risk of joint pain was increased in some studies (28,31), but not others (12,29). Two studies reported a 1.8 to 2.3-fold increase in risk of morning or joint stiffness among women with breast implants compared to women with other cosmetic surgeries or from the general population (15,29).…”

Section: Ra and Joint-related Symptomsmentioning

confidence: 99%

“…The risk of photosensitivity was increased in one small study (31), but not in others (15,(28)(29)(30)34) (Supplementary File 2: https://cdn.amegroups.cn/static/public/gs-21-266-2.pdf). Cohort studies reported no increased risk of malar or discoid rash (15), oral ulcers (15,28,29,31), serositis or pleuritis (15,29,31), proteinuria or kidney disease (31), cytopenia (31), or livedo reticularis (10), although CIs were often wide.…”

Section: Sle and Related Symptomsmentioning

confidence: 99%

“…In Watad et al, disease-specific HRs were obtained by personal communication with study authors. C, cosmetic augmentation; CI, confidence interval; CTD, connective tissue disease; FM, fibromyalgia; HR, hazard ratio; N/A, not applicable; NOS, Newcastle-Ottawa scale; NR, not reported; OR, odds ratio; RA, rheumatoid arthritis; RR, relative risk; SES, socioeconomic status; SHR, standardized hospitalization ratio; SIR, standardized incidence ratio; y, years; $, potential financial or other conflict of interest.other cosmetic surgeries (OR 2.43, 95% CI: 1.29-4.57 for regularly burning eyes) (31), or from the general population [OR 4.5, 95% CI: 1.0-20.7 for dry mouth(29)]. Conversely, two high-quality cohort studies reported no increased risk in sicca symptoms compared to patients with other cosmetic surgeries(27) or from the community (15) (Supplementary File 2: https://cdn.amegroups.cn/static/ public/gs-21-266-2.pdf).…”

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confidence: 99%

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Risk of rheumatic disease in breast implant users: a qualitative systematic review

Hoa¹,

Milord²,

Hudson³

et al. 2021

Gland Surg

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Background: Recent studies on the risk of rheumatic disease among breast implant users have reported conflicting results. The primary objective of this study was to provide a systematic and critical review of the literature on the association between breast implants and the risk of rheumatic disease.Methods: A qualitative systematic review was conducted in PubMed, MEDLINE, EMBASE, EBM-Reviews and CINAHL Complete from database inception to June 23rd, 2021. Eligible papers were full-length articles in English or French reporting original data on the incident risk of rheumatic disease among individuals with and without breast implants. Data were extracted from published reports and appraised using the Newcastle-Ottawa scale. The main outcome was incident risk of systemic sclerosis (SSc), Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), fibromyalgia and other rheumatic disorders and symptoms.Results: Out of 3,425 identified citations, 86 met inclusion criteria. Two cohort studies suggested a twofold increase in risk of SSc, whereas three case-control studies showed no increase in risk. Three cohort studies did not find an increased risk of incident and confirmed SS among breast implant users, however symptoms of sicca, myalgia and fatigue were reported more frequently. A meta-analysis of heterogenous studies reported a less than two-fold increase in risk of RA. Studies did not support an association with SLE. Insufficient evidence was available for autoimmune myositis and other rheumatic diseases. Implant rupture detected on imaging was not clearly associated with incident rheumatic disease, although no studies specifically examined the risk associated with acute/traumatic rupture. Little data was available on the safety of saline breast implants. Explantation often led to temporary improvement. Conclusions:Based on a small number of high-quality and methodologically robust studies, an association between breast implants and a small increase in risk of SSc and RA could not be excluded. Symptoms of sicca, myalgia and fatigue were reported more frequently among breast implant users. Overall, there remains much uncertainty in regard to the association between breast implants and the risk of incident rheumatic diseases. Individuals considering the placement of breast implants should be informed of this uncertainty.

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“…Gland Surg In contrast, the risk of Raynaud's phenomenon was not increased in five other smaller studies (10,12,(29)(30)(31).…”

Section: Ssc and Raynaud's Phenomenonmentioning

confidence: 85%