Self-Reported Memory Complaints and Memory Performance in Elderly French Community Residents: Results of the PAQUID Research Program

Gagnon, Marc‐André; Dartigues, Jean François; Mazaux, J.-M.; Dequae, L; Letenneur, Luc; Giroire, Jean Michel; Barberger‐Gateau, Pascale

doi:10.1159/000110373

Cited by 144 publications

(130 citation statements)

References 33 publications

(46 reference statements)

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“…Although self-report of cognitive impairments offers the clinician insight into the perceived day-to-day functioning of the individual, the validity of these reports has been questioned in multiple populations on the basis of poor correlations with performance on neuropsychological testing. Self-report of cognitive abilities has been shown to correlate poorly with neuropsychological performance in individuals with multiple sclerosis [18], mild to moderate head injury [19], human immunodeficiency virus [20], and bipolar disorder [21], as well as in nonclinical populations [22][23].…”

Section: Introductionmentioning

confidence: 99%

Self-reported cognitive symptoms following mild traumatic brain injury are poorly associated with neuropsychological performance in OIF/OEF veterans

Spencer

Drag

Walker³

et al. 2010

JRRD

135

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Abstract-Mild traumatic brain injury (mTBI) is not uncommon among Operation Iraqi Freedom/Operation EnduringFreedom (OIF/OEF) veterans, and many individuals within this group report lingering cognitive difficulties following their injury. For Department of Veterans Affairs clinicians, an accurate assessment of cognitive symptoms is important in providing appropriate clinical care. Although self-assessment is commonly employed to screen for difficulties in cognitive functioning, little is known about the accuracy of self-report in this population. This study collected cognitive, psychiatric, and self-report data from 105 OIF/OEF veterans with mTBI to examine the relationship between self-reported cognitive functioning and objective neuropsychological test performance. Additionally, clinicians who frequently work with OIF/OEF veterans were asked to predict the magnitude of these associations. Self-reported cognitive functioning was not significantly correlated with objective cognitive abilities, suggesting that objective neuropsychological testing should be used when cognitive weakness is suspected. Perceived cognitive deficits were associated with depression, anxiety, and posttraumatic stress disorder, illustrating the additional importance of adequate assessment and treatment of psychiatric symptoms. Clinicians tended to overestimate the association between selfreport and test performance.

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Section: Introductionmentioning

confidence: 99%

Self-reported cognitive symptoms following mild traumatic brain injury are poorly associated with neuropsychological performance in OIF/OEF veterans

Spencer

Drag

Walker³

et al. 2010

JRRD

135

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“…This one question has been previously proven to be a sensitive and valid method to assess memory complaints and to predict objective cognitive impairment and dementia. 7,8,[26][27][28] APOE phenotype. Serum samples were obtained and frozen at Ϫ80°C until determination of the APOE phenotype.…”

mentioning

confidence: 99%

Memory complaints and APOE-ε4 accelerate cognitive decline in cognitively normal elderly

Dik¹,

Jonker²,

Comijs³

et al. 2001

Neurology

213

155

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Article abstract-Objective: To investigate to what extent subjective memory complaints and APOE-⑀4 allele carriage predict future cognitive decline in cognitively intact elderly persons, by evaluating both their separate and combined effects. Methods: We selected 1,168 subjects from the population-based Longitudinal Aging Study Amsterdam who were 62 to 85 years of age and had no obvious cognitive impairment at baseline (Mini-Mental State Examination [MMSE] score, Ն27). Memory complaints and APOE phenotypes were assessed at baseline. MMSE, the Auditory Verbal Learning Test (memory: immediate recall and delayed recall), and the Alphabet Coding Task-15 (information processing speed) were used to study cognitive decline. Follow-up data were collected after 3 and 6 years. Data were analyzed with generalized estimating equations, adjusted for age, sex, education, and depression. Results: Baseline memory complaints were reported by 25.5% of the cognitively intact elderly persons. Overall, 25.3% of the subjects were carriers of at least one APOE-⑀4 allele. Memory complaints were associated with a greater rate of decline in all cognitive measures, except immediate recall. In addition, APOE-⑀4 allele carriers had a greater rate of cognitive decline shown by MMSE scores and slower information processing speeds after 6 years. The effects of both memory complaints and APOE-⑀4 allele carriage were additive: subjects with both factors had a two times higher cognitive decline than did subjects without both factors. Conclusions: Both memory complaints and APOE-⑀4 allele carriage predict cognitive decline at an early stage. This finding highlights the importance of subjective memory complaints, which are important even at an early stage when objective tests are still unable to detect cognitive deficits and are especially important for elderly carriers of the APOE-⑀4 allele because they have an additional risk. NEUROLOGY 2001;57:2217-2222 Elderly persons with memory complaints are often depressed. 1,2 However, many population-based studies have reported that subjective memory complaints may predict future dementia. [3][4][5][6] Memory complaints also predict faster cognitive decline in elderly persons with mild cognitive impairment 7 as well as in elderly persons with normal cognition. 8 It is important to know which elderly persons will develop mild cognitive impairment as an early stage of dementia, because intervention may soon be feasible. 9 Because memory complaints can be easily assessed, they can identify persons who are at risk.Small et al. 10 studied individuals with mild memory complaints and found a higher proportion of memory complaints among APOE-⑀4 allele carriers than among non-APOE-⑀4 allele carriers. The APOE-⑀4 allele is the major known genetic risk factor for AD 11 and has been associated with objective cognitive decline. 12-17 Based on the findings of the cross-sectional study by Small et al., 10 prospective studies should include both APOE-⑀4 allele carriage and subjective memory complaints to determine how we...

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“…N umerous studies have sought to evaluate the relationship between self-reported memory complaints and memory performance in elderly populations (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). The results have been mixed-some studies have demonstrated a weak association (1,2,6,9,10,14), while others have not (5,7,12,13)-and the validity of the self-reported memory problems themselves has been questioned.…”

mentioning

confidence: 99%

Association of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment

Schofield

Marder²,

Dooneief³

et al. 1997

AJP

205

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1997; 154:609-615) N umerous studies have sought to evaluate the relationship between self-reported memory complaints and memory performance in elderly populations (1-14). The results have been mixed-some studies have demonstrated a weak association (1, 2, 6, 9, 10, 14), while others have not (5, 7, 12, 13)-and the validity of the self-reported memory problems themselves has been questioned. However, many of these studies have been clinic-based or cross-sectional in design and have not included subjects with cognitive impairment or comparison subjects without memory complaints. We investigated the relationship between memory complaints and cognitive performance among elderly participants of a population-based longitudinal study. In our study, in contrast with many others, not all subjects had memory complaints, some had cognitive impairment, and a proportion of subjects were evaluated twice. METHOD SubjectsSubjects for the current study comprised a subset of subjects in a registry that had been created for the study of aging and neurological conditions in North Manhattan (15). To establish the registry, nursing homes, home health care agencies, private practitioners, and hospital admission and discharge lists were canvassed to identify individuals with possible cognitive impairment. These individuals were then invited to complete a cognitive screening questionnaire (16) that had been modified from the Comprehensive Assessment and Referral Interview (17). Scores on this screening questionnaire could range from 0 to 15, with scores above 2 indicative of possible impairment.

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Self-Reported Memory Complaints and Memory Performance in Elderly French Community Residents: Results of the PAQUID Research Program

Cited by 144 publications

References 33 publications

Self-reported cognitive symptoms following mild traumatic brain injury are poorly associated with neuropsychological performance in OIF/OEF veterans

Self-reported cognitive symptoms following mild traumatic brain injury are poorly associated with neuropsychological performance in OIF/OEF veterans

Memory complaints and APOE-ε4 accelerate cognitive decline in cognitively normal elderly

Association of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment

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